Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorIsabel Hostettler

About this trial

The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS dependency in patients suffering from an aneurysmal subarachnoid haemorrhage (aSAH). The main questions we aim to answer are:

* Is there an association of glucose levels on VPS dependency in patients requiring extra-ventricular-drain (EVD) placement for aSAH? * In addition, if there is, what is the influence the course of glucose levels has on VPS dependency?

Glucose levels in CSF and serum will be measured on admission, or in case of CSF, upon EVD placement. Glucose in CSF will then be measured every day until EVD removal together with serum glucose. Follow-up will be conducted in person after 3 and 6 months.

Eligibility criteria

Qualifiers

18 years old and older

Hospital admission due to an aneurysmal subarachnoid haemorrhage (radiological confirmation needed)

Disqualifiers

Younger than 18 years old

Non-aneurysmal subarachnoid haemorrhage (eg. trauma, perimesencephalic subarachnoid haemorrhage, mycotic or flow-associated aneurysms)

Previous enrolment into the current study

Trial design

Treatments tested in this trial

  • Cerebrospinal Fluid (CSF) Sample
  • Blood Serum Sample

Treatment groups

160 Participants
are divided into 1 treatment group

Locations

3
Cantonal Hospital Aarau5001, Aarau Switzerland
University Hospital Basel4031, Basel Switzerland
Cantonal Hospital St Gallen9007, Sankt Gallen Switzerland

Sponsors and collaborators

Isabel Hostettler

Lead sponsor

Cantonal Hospital of St. Gallen

Sponsor institution

Kantonsspital Aarau

Collaborator

University Hospital, Basel, Switzerland

Collaborator