[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558916":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":20,"responsibleParty":68,"collaborators":10,"id":70,"slug":10,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":10,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"NHS Lothian","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Bronchoscopy under ELFMAN",null,"Clinical bronchoscopy performed under ELMAN study",[13],"Diagnostic Test: Single Cell Sequencing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Single Cell Sequencing","Sequencing of all viable single cells present in deep bronchial brushings using transcriptomics to identify what cells are present and what they are doing.",[9],[21,39,51],{"facility":22,"status":23,"city":24,"state":10,"zip":25,"country":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Centre for Information Research, University of Edinburgh","NOT_YET_RECRUITING","Edinburgh","EH16 4UU","United Kingdom",{"type":28,"coordinates":29},"Point",[30,31],-3.19648,55.95206,{"lat":31,"lon":30},[34],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Nik Hirani, MBBS","CONTACT","01312421836","n.hirani@ed.ac.uk",{"facility":40,"status":23,"city":24,"state":10,"zip":25,"country":26,"cosmosGeoPoint":41,"geoPoint":43,"contacts":44},"Henderson Lab",{"type":28,"coordinates":42},[30,31],{"lat":31,"lon":30},[45,48],{"name":46,"role":36,"phone":10,"phoneExt":10,"email":47},"Neil Henderson","neil.henderson@ed.ac.uk",{"name":49,"role":36,"phone":10,"phoneExt":10,"email":50},"Prasad Velu","ppalani@exseed.ed.ac.uk",{"facility":52,"status":53,"city":24,"state":10,"zip":54,"country":26,"cosmosGeoPoint":55,"geoPoint":57,"contacts":58},"Edinburgh Cancer Centre","RECRUITING","EH4 2XU",{"type":28,"coordinates":56},[30,31],{"lat":31,"lon":30},[59,64],{"name":60,"role":36,"phone":61,"phoneExt":62,"email":63},"Stephen J Harrow, MB ChB","01315371000","32111","stephen.harrow2@nhs.scot",{"name":65,"role":36,"phone":61,"phoneExt":66,"email":67},"Stuart R Walter, BMBS","31777","stuart.walter@nhs.scot",{"type":69,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100558916",false,"NCT06557343","Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy","SPITFIRE","Inclusion Criteria:\n\n* Age over 18 years\n* Patient has received thoracic radiotherapy and has clinical or radiological features in fitting with a diagnosis of Radiation Pneumonitis (onset one to four months post-RT with breathlessness, especially exertional, cough, chest discomfort, which is persistent over weeks, a chest x-ray \\[CXR\\] may demonstrate patchy or widespread opacification although can be normal.)\n* Must be ambulant, oxygen independent with SpO2 \\>92% on air and haemodynamically stable to be considered safe for a bronchoscopy.\n* Willing to undergo and likely able to tolerate bronchoscopy, ie. Can lie flat without compromising ventilation, and able to consent to the ELFMAN Protocol and SPITFIRE trial.\n\nExclusion Criteria:\n\n* Contraindication to bronchoscopy, ie. Previously not tolerated, unable to lie flat, Sp02 \\\u003C92% on air\n* Patient requires admission or oxygen dependant\n* Test positive for Covid-19 within the preceding six weeks to enrolment","ALL","18 Years",{"count":79,"type":80},5,"ESTIMATED","OBSERVATIONAL","Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel technique which allows for identification of which cells are present and what they are doing. This hopes to better understand radiation pneumonitis, a dose-limiting toxicity in cancer treatment which can be highly morbid and even fatal.",[84],"Radiation Pneumonitis",[86,87,88],"radiation pneumonitis","cancer","single cell sequencing","2026-01-08",{"date":91,"type":92},"2026-01-09","ACTUAL",{"date":94,"type":92},"2024-10-25",{"date":96,"type":80},"2026-12",{"name":5,"class":6},3]