[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579447":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":53,"id":59,"slug":24,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":37,"whyStopped":24,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active TMS, Sham TMS","EXPERIMENTAL","Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during wakefulness and\u002For NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.",[13],"Device: TMS",{"label":15,"type":10,"description":16,"interventionNames":17},"Sham TMS, Active TMS","Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered during using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during wakefulness and\u002For NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","TMS","Transcranial magnetic stimulation (TMS) applies magnetic pulses to stimulate nerve cells in the brain.",[9,15],null,[26],{"name":27,"affiliation":5,"role":28},"Umair Hassan, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Hansong Lee, MS","CONTACT","408-909-2203","kellerlab@stanford.edu",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Stanford","California","94305","United States",{"type":43,"coordinates":44},"Point",[45,46],-122.16608,37.42411,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},{"type":28,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Umair Hassan","Postdoctoral Researcher in Department of Psychiatry and Behavioral Sciences",[54,57],{"name":55,"class":56},"National Center for Advancing Translational Sciences (NCATS)","NIH",{"name":58,"class":56},"National Institute of Mental Health (NIMH)","100579447",false,"NCT06824415","Sleep TMS for Depression","Optimizing Depression Treatment Through Sleep-state Brain Stimulation","Inclusion Criteria:\n\n* Adults ages 18-65 years\n* Current Major Depressive Disorder (MDD) diagnosis\n* Failed ≥1 antidepressant medication\n* Moderate-to-severe depression\n* Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment\n* Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS\u002FMRI contraindications.\n\nExclusion Criteria:\n\n* Intellectual disability\n* Significant head injury\u002Fneurological disorder\n* Pregnancy or postpartum\n* TMS\u002FMRI contraindications\n* Active substance use\u002Fsuicidal ideation",true,"ALL","18 Years","65 Years",{"count":70,"type":71},55,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.",[77,78],"Major Depression","Sleep",[80,81,82,83,84,85,86,87,88],"sleep","tms","eeg","iTBS","real-time","closed-loop","NREM","sleep spindle","slow oscillations","2026-06-18",{"date":91,"type":92},"2026-06-23","ACTUAL",{"date":94,"type":92},"2025-05-01",{"date":96,"type":71},"2028-05-30",{"name":5,"class":6},1]