Health Trials

About this trial

The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown.

The iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.

Eligibility criteria

Qualifiers

Patient carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM)

Capsule endoscopy screening for (pre)neoplastic lesions of the small intestine

No opposition to the reuse of healthcare data for research purposes

Disqualifiers

Absence of documented MMR gene variant

Opposition to the study

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

No trial groups listed

Locations

1
Center for Digestive Endoscopy, Saint-Antoine Hospital Paris France

Sponsors and collaborators

Assistance Publique - Hôpitaux de Paris

Lead sponsor

Source ClinicalTrials.gov