[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609966":3},{"organization":4,"outcomesModule":7,"designInfo":52,"detailedDescription":61,"studyPopulation":55,"armGroups":62,"interventions":73,"overallOfficials":83,"centralContacts":87,"locations":95,"responsibleParty":111,"collaborators":114,"id":118,"slug":55,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":55,"eligibilityCriteria":123,"healthyVolunteers":124,"sex":125,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":55,"studyType":131,"phases":132,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":97,"whyStopped":55,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":147,"completionDateStruct":148,"leadSponsor":150,"locationsCount":151},{"fullName":5,"class":6},"Florida State University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":29,"otherOutcomes":36},[9,13,17,20,23,26],{"measure":10,"description":11,"timeFrame":12},"Change in dietary sodium intake","Dietary sodium intake will be assessed via participant self-reported 3 day diet record","Baseline; 2 month, 4month, 6month",{"measure":14,"description":15,"timeFrame":16},"Change in dietary potassium intake","Dietary potassium intake will be assessed via participant self-reported 3-day diet record","Baseline, 2month, 4month, 6month",{"measure":18,"description":19,"timeFrame":16},"Change in 24-hour urinary sodium excretion","Urinary sodium excretion obtained from 24-hour urine sample",{"measure":21,"description":22,"timeFrame":16},"Change in 24-hour urinary potassium excretion","Urinary potassium excretion measured from 24-hour urine sample",{"measure":24,"description":25,"timeFrame":12},"Change in Blood pressure","Seated, automated blood pressure mmHg",{"measure":27,"description":28,"timeFrame":12},"Change in Endothelial function","brachial artery flow-mediated dilation as measured in % dilation",[30,33],{"measure":31,"description":32,"timeFrame":16},"Direct measurement of arterial stiffness","Carotid-femoral pulse wave velocity reported in m\u002Fs",{"measure":34,"description":35,"timeFrame":16},"Indirect measurement of arterial stiffness","Augmentation obtained from the brachial artery pressure waveform using a blood pressure cuff on the upper arm, reported as %",[37,40,43,46,49],{"measure":38,"description":39,"timeFrame":12},"Change in Body weight","body weight assessed in kilograms",{"measure":41,"description":42,"timeFrame":16},"Change in total cholesterol","Fasting total cholesterol obtained as part of standard lipid panel",{"measure":44,"description":45,"timeFrame":16},"Change in LDL cholesterol","Fasting LDL cholesterol obtained as part of a standard lipid panel",{"measure":47,"description":48,"timeFrame":16},"Change in HDL cholesterol","Fasting HDL cholesterol obtained as part of a standard lipid panel",{"measure":50,"description":51,"timeFrame":16},"Change in triglycerides","Fasting triglycerides obtained as part of a standard lipid panel",{"allocation":53,"interventionModel":54,"interventionModelDescription":55,"primaryPurpose":56,"observationalModel":55,"timePerspective":55,"maskingInfo":57},"RANDOMIZED","PARALLEL",null,"PREVENTION",{"masking":58,"maskingDescription":55,"whoMasked":59},"SINGLE",[60],"OUTCOMES_ASSESSOR","High sodium diets are a major contributor to cardiovascular disease. Unfortunately, reducing sodium intake can be challenging. It is known that increasing potassium intake can improve cardiovascular disease risk factors in a laboratory setting. The investigators are hoping to show that it is more feasible and effective for individuals to increase their potassium intake, rather than reduce their sodium intake, to improve cardiovascular disease risk factors, including blood pressure and endothelial function.\n\nIn this study, participants will be randomly assigned to receive individualized education over the course of four weeks to help them adopt one of two dietary patterns: 1) a self-selected low sodium diet (goal: ≤1,500 mg\u002Fday) or 2) a self-selected high potassium diet (goal: ≥4,700 mg\u002Fday). Participants will be provided individualized nutrition education once per week, at the participant's convenience by trained study staff to help them meet the target nutrition goals. No food, supplements, or devices will be provided to participants, and participants will be advised not to take any dietary supplements containing potassium during the intervention and follow-up period. Follow up with participants will be every two months for six months post-education to measure compliance with the desired dietary changes as well as changes in cardiovascular health.",[63,68],{"label":64,"type":65,"description":55,"interventionNames":66},"High potassium dietary education","EXPERIMENTAL",[67],"Behavioral: High potassium dietary education\u002Fcounseling",{"label":69,"type":70,"description":55,"interventionNames":71},"Low sodium dietary education","ACTIVE_COMPARATOR",[72],"Behavioral: Low sodium dietary education\u002Fcounseling",[74,79],{"type":75,"name":76,"description":77,"armGroupLabels":78,"otherNames":55},"BEHAVIORAL","High potassium dietary education\u002Fcounseling","Participants assigned to this intervention arm will receive four weekly individualized education sessions on how to increase their dietary potassium intake.",[64],{"type":75,"name":80,"description":81,"armGroupLabels":82,"otherNames":55},"Low sodium dietary education\u002Fcounseling","Participants assigned to this intervention arm will receive four weekly individualized education sessions on how to reduce their dietary sodium intake.",[69],[84],{"name":85,"affiliation":5,"role":86},"Andrea Lobene, PhD, RD, LD","PRINCIPAL_INVESTIGATOR",[88,92],{"name":85,"role":89,"phone":90,"phoneExt":55,"email":91},"CONTACT","850-644-1829","alobene@fsu.edu",{"name":93,"role":89,"phone":94,"phoneExt":55,"email":55},"FSU Ann's College","850-644-6685",[96],{"facility":5,"status":97,"city":98,"state":99,"zip":100,"country":101,"countryCode":102,"cosmosGeoPoint":103,"geoPoint":108,"contacts":109},"RECRUITING","Tallahassee","Florida","32304","United States","US",{"type":104,"coordinates":105},"Point",[106,107],-84.28073,30.43826,{"lat":107,"lon":106},[110],{"name":85,"role":89,"phone":90,"phoneExt":55,"email":91},{"type":86,"investigatorFullName":112,"investigatorTitle":113,"investigatorAffiliation":5,"oldNameTitle":55,"oldOrganization":55},"Andrea Lobene","Assistant Professor",[115],{"name":116,"class":117},"United States Department of Agriculture (USDA)","FED","100609966",false,"NCT07221448","Sodium vs Potassium Education to Improve Vascular Health","Improving Vascular Health Using Nutrition Education Aimed At Increasing Potassium Intake Versus Reducing Sodium Intake","Inclusion Criteria:\n\n* Willing and able to attend in-person laboratory visits\n* Usual sodium intake ≥3,000 mg\u002Fd for females and ≥4,000 mg\u002Fd for males\n* Usual potassium intake ≤2,500 mg\u002Fd in females and ≤3,000 mg\u002Fd in males\n\nExclusion Criteria:\n\n* BMI ≥35 kg\u002Fm2\n* Seated blood pressure ≥130\u002F80 mmHg\n* Current diagnosis or history of diabetes, renal disease, cancer, cardiovascular disease, or major cardiovascular event (e.g. heart attack or stroke)\n* Current or recent use of a diuretic (within the past 6 months)\n* Elevated blood lipids (LDL cholesterol ≥190 mg\u002FdL)\n* Elevated serum potassium level (\\>5.1 mmol\u002FL)\n* Elevated BUN (\\>22 mg\u002FdL)\n* Elevated creatinine (\\>1.2 mg\u002FdL)\n* Low eGFR (\\\u003C90 mL\u002Fmin\u002F1.73 m²)\n* Current or recent use of tobacco, nicotine, or illicit drugs\n* Radical hysterectomy or oophorectomy (females)\\*\n* Pregnant or lactating\n* Following a weight-loss diet, or intending to gain or lose weight during the study period",true,"ALL","18 Years","45 Years",{"count":129,"type":130},32,"ESTIMATED","INTERVENTIONAL",[133],"NA","The goal of this clinical trial is to determine if a self-selected high potassium diet is easier to achieve and more effective at improving vascular health than a low sodium diet in generally healthy young adults who typically consume more than the recommended amount of sodium. The main questions it aims to answer are:\n\n1. Is it easier for young adults to increase their potassium intake, rather than reduce their sodium intake?\n2. Is a self-selected high potassium diet better at improving vascular health compared to a self-selected low sodium diet?\n\nResearchers will compare the effectiveness of an education-based intervention centered only on increasing dietary potassium intake against an education-based intervention centered only on reducing dietary sodium intake.\n\nParticipants will be randomly assigned to receive comprehensive dietary education on adopting either a high-potassium diet or a low-sodium diet.\n\nEducation will be delivered in four weekly one-on-one sessions. Following the four-week education period, participants will be encouraged to change their diet based on what they have learned. Measures of dietary compliance (urine samples and diet records) and cardiovascular health (blood pressure, endothelial function) will be assessed at two, four, and six months post-education.",[136],"Healthy",[138,139,140,141,142],"sodium","potassium","nutrition education","endothelial function","cardiovascular disease risk factors","2026-04-20",{"date":145,"type":146},"2026-04-23","ACTUAL",{"date":143,"type":146},{"date":149,"type":130},"2027-09-30",{"name":5,"class":6},1]