[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587110":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":50,"locations":56,"responsibleParty":74,"collaborators":76,"id":80,"slug":10,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":10,"eligibilityCriteria":84,"healthyVolunteers":81,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":91,"studyType":92,"phases":10,"briefSummary":93,"conditions":94,"keywords":100,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Hospital Universitari Vall d'Hebron Research Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"All patients",null,"Compatible clinical presentation and identification of 2 pathogenic variants in LAMA2, or muscle biopsy with decreased laminin alpha2 protein and at least one pathogenic variant",[13,14,15,16,17,18,19],"Diagnostic Test: Motor function scales","Diagnostic Test: MUSCLE ULTRASOUND","Diagnostic Test: Muscle Elastography","Other: Complete physical examination","Other: Ventilatory\u002F respiratory and other support assessment","Other: Oromotor function and nutrition","Other: Motor Milestone Assessments",[21,26,30,34,38,42,46],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DIAGNOSTIC_TEST","Motor function scales","Evaluation of patients motor function using motor scales (MFM32, CHOP)",[9],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"MUSCLE ULTRASOUND","Ultrasound guided evaluation of 28 muscles evaluated accross different body regions, assessed using the Heckmatt gradinf system (semiquantitative scale).",[9],{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Muscle Elastography","Assess the mechanical properties of muscles, such as stiffness and elasticity.",[9],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":10},"Complete physical examination","Complete physical evaluations including muscle power and goniometry measurements",[9],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":10},"Ventilatory\u002F respiratory and other support assessment","Assessment of ventilatory, respiratory, and other support needs to evaluate the necessity of assistive devices",[9],{"type":6,"name":43,"description":44,"armGroupLabels":45,"otherNames":10},"Oromotor function and nutrition","Assessment of bulbar funcionality: feeding devices, nutritional status.",[9],{"type":6,"name":47,"description":48,"armGroupLabels":49,"otherNames":10},"Motor Milestone Assessments","Motor milestones age of acquisition and loss",[9],[51],{"name":52,"role":53,"phone":54,"phoneExt":10,"email":55},"David Gómez-Andrés","CONTACT","+34934893156","david.gomezandres@vallhebron.cat",[57],{"facility":58,"status":59,"city":60,"state":60,"zip":61,"country":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"University Hospital Vall d'Hebron","RECRUITING","Barcelona","08035","Spain",{"type":64,"coordinates":65},"Point",[66,67],2.15899,41.38879,{"lat":67,"lon":66},[70],{"name":71,"role":53,"phone":72,"phoneExt":10,"email":73},"Neurologia Pediatrica - HUVH","934893156","neurologia.pediatrica@vallhebron.cat",{"type":75,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[77],{"name":78,"class":79},"ASOCIACIÓN IMPÚLSATE PARA LA CURA DE LOS NIÑOS CON DÉFICIT DE MEROSINA","UNKNOWN","100587110",false,"NCT06924125","Spanish Natural History Study for LAMA2 Muscular Dystrophy","Inclusion Criteria:\n\n* All patients with compatible clinical presentation and identification of 2 pathogenic variants in LAMA2, or muscle biopsy with decreased laminin alpha2 protein and at least one pathogenic variant\n* Signed informed consent by the Legal Authority Responsible and\u002For assent by the subject (starting from 6 years old)","ALL","0 Minutes","100 Years",{"count":89,"type":90},100,"ESTIMATED","5 Years","OBSERVATIONAL","The objective of this natural history study is to comprehensively characterize the disease progression and clinical features of LAMA2-related dystrophies (LAMA2-RD) in the pediatric population. The study aims to establish a well-defined cohort of patients in Spain, enabling long-term follow-up and facilitating recruitment for future clinical trials.",[95,96,97,98,99],"LAMA2-MD (Merosin Deficient Congenital Muscular Dystrophy, MDC1A)","Merosin Deficient CMD (Full or Partial)","Merosin Deficient Congenital Muscular Dystrophy","Muscular Dystrophies","Cohort Studies",[101,102,103,104,105],"Merosin","LAMA2","Laminin","Dystrophy","natural history","2025-04-05",{"date":108,"type":109},"2025-04-11","ACTUAL",{"date":111,"type":109},"2021-07-27",{"date":113,"type":90},"2030-07-01",{"name":5,"class":6},1]