[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100406027":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":28,"overallOfficials":34,"centralContacts":39,"locations":46,"responsibleParty":63,"collaborators":13,"id":66,"slug":13,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":13,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":13,"enrollmentInfo":75,"targetDuration":13,"studyType":78,"phases":13,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":49,"whyStopped":13,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Aalborg University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Diagnostic accuracy","How accurate can the methylation profiles diagnose the head and neck squamous cell carcinoma","At diagnosis",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"CASE_CONTROL","PROSPECTIVE","Cancer group:\n\nPatients referred from the region of Northern Denmark to the Department of Otorhinolaryngology - Head and Neck Surgery with suspicion of, or with already verified Head and neck squamous cell carcinoma. Only patients with verified squamous cell carcinoma after diagnostic work-up will be eligible.\n\nControl group:\n\nPatients referred from the region of Northern Denmark to the Department of Otorhinolaryngology - Head and Neck Surgery for evaluation or treatment, but without suspected or verified malignancy of the head and neck.",[19,24],{"label":20,"type":13,"description":21,"interventionNames":22},"Cancer group","Patients with verified head and neck squamous cell carcinomas",[23],"Diagnostic Test: Blood sample",{"label":25,"type":13,"description":26,"interventionNames":27},"Control group","Matched control group without active or earlier cancer and a normal ENT examination.",[23],[29],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":13},"DIAGNOSTIC_TEST","Blood sample","A separate blood sample will be taken for methylation-analyses",[20,25],[35],{"name":36,"affiliation":37,"role":38},"Michael Gaihede, Professor","Department of Otolaryngology - Head and Neck Surgery, Aalborg University Hospital","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":13,"email":44},"Christian Danstrup, M.D.","CONTACT","+45 23800598","csd@rn.dk",{"name":36,"role":42,"phone":13,"phoneExt":13,"email":13},[47],{"facility":48,"status":49,"city":50,"state":13,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Department of Otolaryngology - Head and Neck Surgery","RECRUITING","Aalborg","9000","Denmark","DK",{"type":55,"coordinates":56},"Point",[57,58],9.9187,57.048,{"lat":58,"lon":57},[61],{"name":62,"role":42,"phone":43,"phoneExt":13,"email":44},"Christian Danstrup, M.D",{"type":38,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Christian Sander Danstrup","Associate Professor, M.D.","100406027",false,"NCT04567056","Specific Methylation Profiles in HNSCC","Validation of Specific Methylation Profiles Ind Head and Neck Cancer - a Cohort Study","Cancer group:\n\nInclusion Criteria:\n\n* Written informed consent\n* Verified head and neck squamous cell carcinoma\n\nExclusion Criteria:\n\n* Other active cancer\n* Uncontrolled comorbidity\n* Unable to give informed consent\n\nControl group:\n\nInclusion Criteria:\n\n* Written informed consent\n* Normal ENT-examination\n\nExclusion Criteria:\n\n* Other active cancer\n* Uncontrolled comorbidity\n* Unable to give informed consent",true,"ALL","18 Years",{"count":76,"type":77},300,"ESTIMATED","OBSERVATIONAL","In the study, N-20190047, the investigators aim to define specific methylation patterns in a group of patients with head and neck squamous cell carcinomas.\n\nWith this study the investigators aim to validate these findings in a larger cohort.",[81],"Head and Neck Squamous Cell Carcinoma",[83,84,85,86],"Head and neck cancer","Squamous Cell carcinoma","Methylation","DNA","2025-02-05",{"date":89,"type":90},"2025-02-07","ACTUAL",{"date":92,"type":90},"2020-09-16",{"date":94,"type":77},"2026-06-01",{"name":5,"class":6},1]