[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634791":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":18,"responsibleParty":42,"collaborators":7,"id":46,"slug":7,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":7,"enrollmentInfo":54,"targetDuration":57,"studyType":58,"phases":7,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":67,"whyStopped":7,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Anna Palmisano, Medicine and Surgery","CONTACT","+39 3200985665","palmisano.anna@hsr.it",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Davide Vignale, Medicine and Surgery","+39 3480521191","vignale.davide@hsr.it",[19,34],{"facility":20,"status":7,"city":21,"state":22,"zip":23,"country":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Azienda Ospedaliero-Universitaria Sant'Andrea","Roma","RM","00189","Italy",{"type":26,"coordinates":27},"Point",[28,29],11.10642,44.99364,{"lat":29,"lon":28},[32],{"name":33,"role":11,"phone":7,"phoneExt":7,"email":7},"Damiano Caruso, Medicine and Surgery",{"facility":35,"status":7,"city":36,"state":7,"zip":7,"country":24,"cosmosGeoPoint":37,"geoPoint":41,"contacts":7},"IRCCS Ospedale San Raffaele","Milan",{"type":26,"coordinates":38},[39,40],9.18951,45.46427,{"lat":40,"lon":39},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Anna Palmisano","MD, PhD","100634791",false,"NCT07544277","Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT","SURE-CT","Inclusion Criteria:\n\n* Patient referred to our hospitals for elective CCTA for ruling out CAD\n* CCTA evidence of moderate stenosis (50-69%) requiring functional assessment according to ESC guidelines\n\nExclusion Criteria:\n\n* hemodynamically unstable conditions,\n* previous revascularization,\n* myocardial infarction,\n* obesity (BMI\\>40 kg\u002Fm2),\n* renal insufficiency (GFR\\\u003C30 mL\u002Fmin),\n* atrial fibrillation or other significant arrhythmias; and\n* other overt cardiovascular diseases affecting CTP performance (e.g., heart failure, severe valvular regurgitation),\n* pregnancy and breastfeeding,\n* contraindications to iodinated contrast agents or regadenoson.","ALL","18 Years",{"count":55,"type":56},142,"ESTIMATED","24 Months","OBSERVATIONAL","Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited specificity for a tendency to overestimate stenoses and for the lack of information about their hemodynamic impact. Fractional Flow Reserve derived from CT (FFR-CT) and stress CT perfusion (CTP) have been recently proposed to complement CCTA in the non-invasive assessment of myocardial ischemia, increasing the specificity and avoiding unnecessary catheterization. However, on energy-integrating (EID)-CT, FFR-CT has suboptimal performance, while CTP is affected by high radiation exposure. Both these approaches may benefit by the introduction of the new Photon Counting Detector (PCD)-CT technology, but data completely lacks. Aim of the study is to assess the performance of PCD-CT in the identification of significant CAD combining CCTA with FFR-CT and spectral CTP.",[61,62,63,64],"FFR-CT","CT Angiography","CT Perfusion","Coronary Arterial Disease (CAD)",[61,66,63,64],"Coronary CT angiography","NOT_YET_RECRUITING","2026-04-15",{"date":70,"type":71},"2026-04-22","ACTUAL",{"date":73,"type":56},"2026-09-01",{"date":75,"type":56},"2029-09-01",{"name":5,"class":6},2]