[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517726":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":11,"studyPopulation":11,"armGroups":49,"interventions":61,"overallOfficials":66,"centralContacts":71,"locations":79,"responsibleParty":102,"collaborators":11,"id":104,"slug":11,"hasResults":105,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":105,"sex":111,"minAge":112,"maxAge":11,"enrollmentInfo":113,"targetDuration":11,"studyType":116,"phases":117,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":82,"whyStopped":11,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":134},{"fullName":5,"class":6},"Universität Münster","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Number of days alive and free from CRRT",null,"Between Randomization and day 28",[14,17,19,21,23,26,29,31,33,36],{"measure":15,"description":11,"timeFrame":16},"Number of Adverse Events (rooted in uraemia, i.e. throwing up, seizures, uremic coma etc.)","Between randomization and day 28",{"measure":18,"description":11,"timeFrame":16},"Number of days with renal replacement therapy",{"measure":20,"description":11,"timeFrame":16},"Length of Intensive Care Unit (ICU) stay",{"measure":22,"description":11,"timeFrame":16},"Length of Hospital stay",{"measure":24,"description":11,"timeFrame":25},"Mortality","Day 30 after randomization",{"measure":27,"description":11,"timeFrame":28},"Number of new infections since randomization","From randomization until day 30",{"measure":30,"description":11,"timeFrame":28},"Total amount of dialysis fluid utilized adjusted for weight",{"measure":32,"description":11,"timeFrame":25},"Number of patients alive and dialysis-free at day 30",{"measure":34,"description":35,"timeFrame":25},"Presence of Major adverse kidney events (MAKE)","Composite endpoint consisting of death, renal replacement therapy, and persistent severe AKI lasting for 72 hours or more",{"measure":37,"description":11,"timeFrame":38},"Expense of treatment (including hospital stay\u002Fall measures taken)","From randomization until day 30 after randomization",{"allocation":40,"interventionModel":41,"interventionModelDescription":11,"primaryPurpose":42,"observationalModel":11,"timePerspective":11,"maskingInfo":43},"RANDOMIZED","PARALLEL","SUPPORTIVE_CARE",{"masking":44,"maskingDescription":11,"whoMasked":45},"TRIPLE",[46,47,48],"PARTICIPANT","CARE_PROVIDER","OUTCOMES_ASSESSOR",[50,56],{"label":51,"type":52,"description":53,"interventionNames":54},"Intervention Group","EXPERIMENTAL","CRRT will be established with a draining dose (effluent dose) of 10-15ml\u002Fkg\u002Fh in pursuit of establishing a controlled azotaemia.",[55],"Other: Effluent dose of CRRT",{"label":57,"type":58,"description":59,"interventionNames":60},"Control Group","ACTIVE_COMPARATOR","Standard of Care:\n\nCRRT will be established with a draining dose (effluent dose) of 25-30ml\u002Fkg\u002Fh",[55],[62],{"type":6,"name":63,"description":64,"armGroupLabels":65,"otherNames":11},"Effluent dose of CRRT","The effluent dose of the CRRT will be performed according to study group for 7 days or up to the end of CRRT, whatever occurs first.",[57,51],[67],{"name":68,"affiliation":69,"role":70},"Alexander Zarbock, MD","WWU Münster","STUDY_CHAIR",[72,76],{"name":68,"role":73,"phone":74,"phoneExt":11,"email":75},"CONTACT","+492518347255","aki@anit.uni-muenster.de",{"name":77,"role":73,"phone":74,"phoneExt":11,"email":78},"Melanie Meersch-Dini, MD","aki@uni-muenster.de",[80,93],{"facility":81,"status":82,"city":83,"state":11,"zip":84,"country":85,"countryCode":86,"cosmosGeoPoint":87,"geoPoint":92,"contacts":11},"University Hospital Münster","RECRUITING","Münster","48149","Germany","DE",{"type":88,"coordinates":89},"Point",[90,91],7.62571,51.96236,{"lat":91,"lon":90},{"facility":94,"status":82,"city":95,"state":11,"zip":96,"country":85,"countryCode":86,"cosmosGeoPoint":97,"geoPoint":101,"contacts":11},"Universitätsklinikum Tübingen; Universitätsklinik für Anästhesiologie und Intensivmedizin","Tübingen","72076",{"type":88,"coordinates":98},[99,100],9.05222,48.52266,{"lat":100,"lon":99},{"type":103,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100517726",false,"NCT06021288","Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )","A Randomized Controlled Study Investigating Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT - The \"Ketzerei\" Trial","KETZEREI","Inclusion Criteria:\n\n* Adult patients (age ≥18 years)\n* Critically ill patients with AKI + in need of CRRT\n* Written informed consent\n\nExclusion Criteria:\n\n* Chronic dialysis dependency\n* Chronic kidney disease with estimated glomerular filtration rate (eGFR) \\\u003C30 ml\u002Fmin\u002F1.73m²\n* severe liver cirrhosis (Child-pugh C)\n* severe acidosis (pH \\\u003C 7,20 at study enrolment)\n* severe hyperkalaemia (\\> 6mmol\u002Fl)\n* Pregnancy or breastfeeding\n* persons held in an institution by legal or official order\n* Dependency on the investigator or center","ALL","18 Years",{"count":114,"type":115},165,"ESTIMATED","INTERVENTIONAL",[118],"NA","Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).\n\nIn current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients.\n\nThe aim of the study is to improve renal recovery.",[121,122],"Critical Illness","Acute Kidney Injury",[124],"Continuous renal replacement therapy","2024-11-25",{"date":127,"type":128},"2024-11-27","ACTUAL",{"date":130,"type":128},"2023-10-02",{"date":132,"type":115},"2025-06-30",{"name":5,"class":6},2]