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Despite advances in screening, limited evidence exists on how clinical, metabolic, and immunological markers evolve over time and predict progression to symptomatic disease. Using a screened cohort, participants are followed for up to 10 years with repeated standardized assessments. The study evaluates whether population-based screening can reduce diabetic ketoacidosis (DKA) at diagnosis and identify early predictors of progression to clinical T1D. Results are expected to improve risk stratification, inform surveillance strategies, and guide the timing of preventive interventions, with implications for clinical practice and health policy.",[308,309,310,311],"Type 1 Diabetes (T1D)","Autoantibodies","Hyperglycemia","Impaired Glucose Tolerance (Prediabetes)",[313,309,314,315,310,316,317,318,319,320,321,322,323,324,325,326],"Diabetes Mellitus, Type 1","Islets of Langerhans","Autoimmune Diseases","Impaired Glucose Tolerance","C-Peptide","Oral Glucose Tolerance Test","Continuous Glucose Monitoring","Psychological Stress","Early Diagnosis","Disease Progression","Presymptomatic Type 1 Diabetes","Type 1 Diabetes Stage 1","Type 1 Diabetes Stage 2","Type 1 Diabetes Stage 3","NOT_YET_RECRUITING","2026-04-02",{"date":330,"type":331},"2026-04-08","ACTUAL",{"date":333,"type":304},"2026-05",{"date":335,"type":304},"2036-04",{"name":5,"class":6},24]