[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100378231":3},{"organization":4,"outcomesModule":7,"designInfo":52,"detailedDescription":51,"studyPopulation":55,"armGroups":56,"interventions":61,"overallOfficials":66,"centralContacts":71,"locations":80,"responsibleParty":117,"collaborators":51,"id":119,"slug":51,"hasResults":120,"nctId":121,"briefTitle":122,"officialTitle":122,"acronym":51,"eligibilityCriteria":123,"healthyVolunteers":120,"sex":124,"minAge":125,"maxAge":51,"enrollmentInfo":126,"targetDuration":51,"studyType":129,"phases":51,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":83,"whyStopped":51,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":51,"otherOutcomes":51},[9,13,16,18,21,24,27,30,33,36,39,42,45,48],{"measure":10,"description":11,"timeFrame":12},"Demographics","age, sex","between 01.01.2005 and 31.12.2023",{"measure":14,"description":15,"timeFrame":12},"Data from acute prehospital management by the emergency medical services (EMS)","extracted from the treatment protocols of the EMS",{"measure":17,"description":17,"timeFrame":12},"Duration of ICU (intensive care unit) and hospital stay, and destination at discharge",{"measure":19,"description":20,"timeFrame":12},"Date(s) of seizure(s) captured by electroencephalographic (EEG) data","Date(s) of seizure(s) captured by EEG",{"measure":22,"description":23,"timeFrame":12},"Seizure history and etiology","withdrawal from anti seizure drugs, structural, infectious, or autoimmune causes",{"measure":25,"description":26,"timeFrame":12},"Number and Duration of SE episodes","Number and Duration (time) of SE episodes",{"measure":28,"description":29,"timeFrame":12},"Types of SE","Types of SE according to the current guidelines from the International League of Epilepsy (ILAE) (i.e., nonconvulsive with coma, SE with motor symptoms, focal nonconvulsive SE without coma, and subtle SE",{"measure":31,"description":32,"timeFrame":12},"Additional features of the seizure","length, level of consciousness at onset, previous epileptic seizures",{"measure":34,"description":35,"timeFrame":12},"ICU Scoring Systems","Critical illness severity scores (e.g., acute physiology and chronic health Evaluation (APACHE II), simplified acute physiology score (SAPS II), sequential organ failure assessment (SOFA), etc.)",{"measure":37,"description":38,"timeFrame":12},"Clinical neurologic monitoring scores","Clinical neurologic monitoring scores (e.g., Richmond Agitation-Sedation Scale (RASS) , Seda-tion-Agitation Scale (SAS), Glasgow Coma Score (GCS), Intensive Care Delirium Screening Checklist (ICDSC), Status Epilepticus Severity Score (STESS))",{"measure":40,"description":41,"timeFrame":12},"Laboratory parameters","C-Reactive Protein (CRP), albumin, Lactate Dehydrogenase (LDH), Creatin-Kinase (CK), procalcitonin, white blood cell levels, creatinine, liver enzymes, blood gas analyses, metabolic data",{"measure":43,"description":44,"timeFrame":12},"Outcome measure","in-hospital death, survival, survival with neurofunctional alteration, Glasgow Outcome Score, return to neurofunctional premorbid baseline, readmission",{"measure":46,"description":47,"timeFrame":12},"Therapeutic features","duration, dosage and number of treatment medication, number of antiseizure drugs, invasive procedures, such as intubation, mechanical, ventilation, vasopressors, installation of central lines, nutrition",{"measure":49,"description":50,"timeFrame":12},"Monitoring of vital signs","blood pressure, heart rate, respiratory rate, oxygen saturation of the blood, body temperature, level of consciousness",null,{"allocation":51,"interventionModel":51,"interventionModelDescription":51,"primaryPurpose":51,"observationalModel":53,"timePerspective":54,"maskingInfo":51},"COHORT","RETROSPECTIVE","Adult patients (i.e., patients ≥18 years of age) with SE treated at the University Hospital Basel and the Cantonal Hospital Aarau.",[57],{"label":58,"type":51,"description":51,"interventionNames":59},"SE patients",[60],"Other: collection of patient data",[62],{"type":6,"name":63,"description":64,"armGroupLabels":65,"otherNames":51},"collection of patient data","Extract data from the digital medical records, the electroencephalographic and microbiologic database.",[58],[67],{"name":68,"affiliation":69,"role":70},"Raoul Sutter, PD Dr. med","Clinic for Intensive Care Medicine, University Hospital Basel","PRINCIPAL_INVESTIGATOR",[72,76],{"name":68,"role":73,"phone":74,"phoneExt":51,"email":75},"CONTACT","+41 61 265 25 25","Raoul.Sutter@usb.ch",{"name":77,"role":73,"phone":78,"phoneExt":51,"email":79},"Saskia Semmlack, Dr. med","+41 61 55 65575","Saskia.Semmlack@usb.ch",[81,100],{"facility":82,"status":83,"city":84,"state":51,"zip":85,"country":86,"countryCode":87,"cosmosGeoPoint":88,"geoPoint":93,"contacts":94},"Cantonal Hospital Aarau (KSA)","RECRUITING","Aarau","5001","Switzerland","CH",{"type":89,"coordinates":90},"Point",[91,92],8.04422,47.39254,{"lat":92,"lon":91},[95,99],{"name":96,"role":73,"phone":97,"phoneExt":51,"email":98},"Markus Gschwind, PD Dr. med.","+41 62 838 66 89","markus.gschwind@ksa.ch",{"name":96,"role":70,"phone":51,"phoneExt":51,"email":51},{"facility":69,"status":83,"city":101,"state":51,"zip":102,"country":86,"countryCode":87,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Basel","4031",{"type":89,"coordinates":104},[105,106],7.57327,47.55839,{"lat":106,"lon":105},[109,111,112,115],{"name":68,"role":73,"phone":74,"phoneExt":51,"email":110},"raoul.sutter@usb.ch",{"name":77,"role":73,"phone":78,"phoneExt":51,"email":79},{"name":113,"role":114,"phone":51,"phoneExt":51,"email":51},"Sarah Tschudin-Sutter, Prof. Dr. med","SUB_INVESTIGATOR",{"name":116,"role":114,"phone":51,"phoneExt":51,"email":51},"Sira Baumann",{"type":118,"investigatorFullName":51,"investigatorTitle":51,"investigatorAffiliation":51,"oldNameTitle":51,"oldOrganization":51},"SPONSOR","100378231",false,"NCT04204863","Status Epilepticus Population Study (STEPS)","Inclusion Criteria:\n\n* Adult patients (i.e., patients ≥18 years of age) with diagnosed SE between 2005 and 2023 who have been treated at the University Hospital of Basel or the Cantonal Hospital Aarau.\n\nExclusion Criteria:\n\n* Patients younger than 18 years.\n* Patients with repetitive epileptic seizures not qualifying for SE.\n* Patients with documented refusal of the general consent.","ALL","18 Years",{"count":127,"type":128},1000,"ESTIMATED","OBSERVATIONAL","The aim of this observational multicenter cohort study is to gain a deeper understanding regarding the effects of treatment adaption based on information from outcome prediction models, risk stratification, as well as treatment monitoring, detection, prevention, and management of complications on course and outcome of adult patients with status epilepticus (SE).",[132],"Epileptic Seizures",[134,135],"Status epilepticus","Electroencephalogram","2026-06-15",{"date":138,"type":139},"2026-06-17","ACTUAL",{"date":141,"type":139},"2019-04-19",{"date":143,"type":128},"2050-12",{"name":5,"class":6},2]