Health Trials

About this trial

SPECTRE is a prospective longitudinal study in order to identify whether patients with different degrees of motor recovery are distinguished by distinct brain post-stroke plasticity patterns in the acute and sub-acute phases. This study allows close longitudinal follow-up of patients with severe clinical motor impairment using functional MRI to study cerebral neuroplasticity after ischemic stroke in the acute and sub-acute phase in patients with upper limb motor impairement, taking into account prognostic criteria used in current practice.

Eligibility criteria

Qualifiers

Adult (age greater than or equal to 18 years) less than 75 years of age, both sexes;

single supratentorial ischemic stroke confirmed by brain imaging

Upper limb deficit defined by a SAFE score <5 (SAFE Stinear protocol, prognosis of post-stroke upper limb recovery) on D3 of stroke. This corresponds to the sum of shoulder abduction and finger extension according to the MRC (Medical Research Council) scale for each of these movements out of 5.

Absence of comprehension disorders limiting participation;

Disqualifiers

If the prognostic group according to the PREP2 algorithm (good, limited and poor) has already been reached during motor evoked potential assessment the patient is excluded.

Recurrence of clinically significant stroke (with worsening NIHSS score > 4) during study.

Trial design

Treatments tested in this trial

  • Clinical scores and functional MRI

Treatment groups

30 Participants
are divided into 1 treatment group

Locations

1
Rennes Chu35033, RennesFrance, France

Sponsors and collaborators

Rennes University Hospital

Lead sponsor

Source ClinicalTrials.gov