[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100271986":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":13,"responsibleParty":31,"collaborators":35,"id":37,"slug":7,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":7,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":7,"enrollmentInfo":45,"targetDuration":7,"studyType":48,"phases":7,"briefSummary":49,"conditions":50,"keywords":7,"overallStatus":16,"whyStopped":7,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":63},{"fullName":5,"class":6},"MaineHealth","OTHER",null,[9],{"name":10,"role":11,"phone":7,"phoneExt":7,"email":12},"Joanne Burgess, RN","CONTACT","burgejs@mmc.org",[14],{"facility":15,"status":16,"city":17,"state":18,"zip":19,"country":20,"cosmosGeoPoint":21,"geoPoint":26,"contacts":27},"Maine Medical Center","RECRUITING","Portland","Maine","04102","United States",{"type":22,"coordinates":23},"Point",[24,25],-70.2589,43.65737,{"lat":25,"lon":24},[28],{"name":10,"role":11,"phone":29,"phoneExt":7,"email":30},"207-662-2414","BURGEJS@mmc.org",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","Douglas B. Sawyer","Chief Academic Officer",[36],{"name":5,"class":6},"100271986",false,"NCT02820233","Studies of Neuregulin\u002FERBB Signaling in Human Heart","Isolation and Characterization of ERBB Expressing Human Heart Progenitor Cells","Inclusion Criteria:\n\n* Clinical diagnosis of severe coronary artery disease scheduled to undergo coronary artery bypass surgery.\n\nExclusion Criteria:\n\n* less than 18 years of age\n* unwilling or unable to provide informed consent\n* known active myocarditis\n* hypertrophic cardiomyopathy\n* constrictive pericarditis or other significant pericardial disease\n* severe pulmonary hypertension\n* significant renal impairment (Cr \\> 2.5 mg\u002FdL)\n* severe ventricular arrhythmias\n* pregnancy","ALL","18 Years",{"count":46,"type":47},80,"ESTIMATED","OBSERVATIONAL","This study examines the role of the epidermal growth factor (EGF) receptor family and the EGF family of ligands in the regulation of non-myocytes isolated from the human heart.",[51,52,53],"Heart Disease","Vascular Disease","Heart Failure","2025-03-31",{"date":56,"type":57},"2025-04-03","ACTUAL",{"date":59,"type":57},"2015-06",{"date":61,"type":47},"2029-06",{"name":33,"class":6},1]