[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639181":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":51,"collaborators":53,"id":56,"slug":25,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":25,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":81,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Ottawa Heart Institute Research Corporation","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Skeletonized Harvesting of LIMA","EXPERIMENTAL","LIMA is harvested using the skeletonized harvesting technique. This technique isolates the artery without the surrounding satellite veins, endothoracic fascia, and intercoastal nerves.",[13],"Procedure: Skeletonized vs non-skeletonized harvesting of the left internal mammary artery",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-Skeletonized Harvesting of LIMA","ACTIVE_COMPARATOR","LIMA is harvested using the non-skeletonized harvesting technique. This technique isolates the artery with the surrounding satellite veins, endothoracic fascia, and intercoastal nerves.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Skeletonized vs non-skeletonized harvesting of the left internal mammary artery","This intervention is the surgical technique used to harvest the artery that will be used to perform the bypass surgery.",[15,9],null,[27],{"name":28,"affiliation":5,"role":29},"Fraser Rubens, MD, MSc.","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Nahya Awada, BSN, MCR, Ph.D.","CONTACT","613-696-7000","naawada@ottawaheart.ca",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"University of Ottawa Heart Institute","Ottawa","Ontario","K1Y 4W7","Canada",{"type":44,"coordinates":45},"Point",[46,47],-75.69812,45.41117,{"lat":47,"lon":46},[50],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"type":52,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[54],{"name":55,"class":6},"Population Health Research Institute","100639181",false,"NCT07599553","Study of Feasibility for Surgical Patients Undergoing Heart Surgery With the Mammary Arteries: Reviewing Infection, Occlusion Rates and Pain Assessments.","Pilot Study for COMFORT Trial Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment","COMFORT pilot","Inclusion Criteria:\n\n* Age 18 years or older\n* Undergoing isolated CABG surgery with median sternotomy and a planned LIMA-LAD graft.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Non-sternotomy surgical approach (e.g., minimally invasive, thoracotomy)\n* Emergency surgery (defined as surgery required within 24 hours or presentation\n* History of prior ternotomy\n* Currently receiving systemic antibiotics or with an active bacterial infection at the time of surgery\n* History of chronic sternal pain prior to the index surgery.\n* Known left subclavian artery stenosis (\\>50%)\n* Previous radiation therapy to the chest\n* Known allergy or contraindication to iodinated contrast media that cannot be managed with premedication.\n* Estimated glomerular filtration rate (eGFR) \\\u003C30 ml\u002Fmin\u002F1.73m2 at baseline (relative contraindications to CTA contrast). The eGFR will be determined by each participating institution according to their standard practice.","ALL","18 Years",{"count":66,"type":67},35,"ESTIMATED","INTERVENTIONAL",[70],"NA","The Pilot study for the COMFORT Trial is a single centre trial to determine the feasibility of the full COMFORT Trial.\n\nThe main COMFORT Trial will be a multi-centre trial to investigate the coronary artery bypass grafting outcomes when harvesting the Left Internal Mammary Artery (LIMA) using a skeletonized approach (artery is isolated without the surrounding veins, fascia and nerves) compared to harvesting the LIMA using a non-skeletonized approach (artery is isolated with the surrounding veins, fascia and nerves). Harvesting the LIMA with the non-skeletonized approach is the standard technique. Participants will complete a Coronary Artery Tomography scan at 1 year to determine if the LIMA graft remains open. Follow up of the participants will continue until 2 years post surgery.",[73],"Graft Patency",[75,76,77,78,79,80],"bypass graft harvesting","skeletonized harvesting","non-skeletonized harvesting","CABG surgery","Left Internal Mammary Artery","LIMA","NOT_YET_RECRUITING","2026-05-14",{"date":84,"type":85},"2026-05-20","ACTUAL",{"date":87,"type":67},"2026-06",{"date":89,"type":67},"2028-06",{"name":5,"class":6},1]