[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622673":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":29,"collaborators":7,"id":31,"slug":7,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":34,"acronym":35,"eligibilityCriteria":36,"healthyVolunteers":32,"sex":37,"minAge":38,"maxAge":7,"enrollmentInfo":39,"targetDuration":42,"studyType":43,"phases":7,"briefSummary":44,"conditions":45,"keywords":49,"overallStatus":52,"whyStopped":7,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":62},{"fullName":5,"class":6},"University College, London","OTHER",null,[9],{"facility":10,"status":7,"city":11,"state":7,"zip":12,"country":13,"cosmosGeoPoint":14,"geoPoint":19,"contacts":20},"Moorfields Eye Hospital","London","N17 9GZ","United Kingdom",{"type":15,"coordinates":16},"Point",[17,18],-0.12574,51.50853,{"lat":18,"lon":17},[21,26],{"name":22,"role":23,"phone":24,"phoneExt":7,"email":25},"Achini K","CONTACT","07951650070","a.makuloluwa@nhs.net",{"name":27,"role":23,"phone":7,"phoneExt":7,"email":28},"James Bainbridge","j.bainbridge@ucl.ac.uk",{"type":30,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100622673",false,"NCT07386678","Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment","Cohort-NHS","Inclusion Criteria:\n\n* Adults ≥18 years\n* Uncomplicated primary rhegmatogenous retinal detachment\n* PVD present\n* No PVR-A\u002FB\u002FC\n* Phakic or pseudophakic.\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years\n* Patients lacking capacity\n* Previous vitrectomy\n* Previous cryopexy\n* Aphakia\n* No fundal view\n* Diabetic retinopathy of any severity\n* Retinal detachment secondary to infective causes e.g. acute retinal necrosis, toxoplasmosis scars\n* Retinal detachment secondary to congenital defects e.g. optic disc pit\u002Fcoloboma\n* Exudative retinal detachment\n* Tractional retinal detachment\n* Ongoing involvement in another ocular trial.","ALL","18 Years",{"count":40,"type":41},50,"ESTIMATED","3 Months","OBSERVATIONAL","Disease or general study area: Uncomplicated rhegmatogenous retinal detachment (RRD) and risk of proliferative vittroretinopathy (PVR)\n\nPurpose and nature of the study:\n\n1. Characterise the cytokine profile of vitreous fluid in uncomplicated RRD.\n2. Develop a risk model to predict development of PVR after retinal detachment surgery using imaging and molecular biomarkers.\n3. To develop deep learning\u002Fartificial intelligence (AI) models for PVR detection in retinal detachment.\n\nInclusion criteria:\n\n50 adult ( ≥18 years) patients with uncomplicated rhegmatogenous retinal detachments without PVR.\n\nWhat participating will involve:\n\nPre- and post-operative assessments and intervention will follow standard of care for patients with rhegmatogenous retinal detachments.\n\nAdditional intervention will include non-invasive imaging of anterior chamber flare, vitreous, wide-field retina, macula optical coherence tomography (OCT) and macula OCT-angiography (OCT-A) as well as, seeking participant's consent on collecting their vitreous fluid at time of their surgery for cytokine analysis.",[46,47,48],"Retinal Detachment Rhegmatogenous","Proliferative Vitreoretinopathy","Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment",[50,51],"Cytokines","Imaging","NOT_YET_RECRUITING","2026-05-05",{"date":55,"type":56},"2026-05-06","ACTUAL",{"date":58,"type":41},"2026-04-27",{"date":60,"type":41},"2027-01-27",{"name":5,"class":6},1]