[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643924":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":10,"responsibleParty":31,"collaborators":33,"id":36,"slug":10,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":10,"enrollmentInfo":44,"targetDuration":10,"studyType":47,"phases":10,"briefSummary":48,"conditions":49,"keywords":52,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":10},{"fullName":5,"class":6},"Centre Hospitalier Intercommunal Creteil","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with biliary tract or pancreatic cancers",null,"Patients included in the TEDOPAM or IMMUNOBIL trials diagnosis of biliary tract or pancreatic cancer",{"label":13,"type":10,"description":14,"interventionNames":10},"Control patients","Subjects from the CHOPPI cohort without biliary tract or pancreatic cancer",[16],{"name":17,"affiliation":18,"role":19},"Pascal ANDUJAR, MD, PhD","Centre Hospitalier intercommunal de Créteil","PRINCIPAL_INVESTIGATOR",[21,27],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"Pacsal ANDUJAR, MD, PhD","CONTACT","01 57 02 20 95","+33","pascal.andujar@chicreteil.fr",{"name":28,"role":23,"phone":29,"phoneExt":25,"email":30},"Camille JUNG, MD, PhD","0157022268","camille.jung@chicreteil.fr",{"type":32,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[34],{"name":35,"class":6},"GERCOR - Multidisciplinary Oncology Cooperative Group","100643924",false,"NCT07668024","Study of Occupational Risk Factors for Biliary and Pancreatic Cancers","PANTOXBIL","Inclusion Criteria:\n\n* Cases :\n\n  * Patients included in the TEDOPAM or IMMUNOBIL trials\n  * Diagnosis of biliary tract or pancreatic cancer\n  * Completed and exploitable curriculum laboris\n* Controls :\n\n  * Subjects from the CHOPPI cohort\n  * Age ≥ 18 years\n  * No biliary tract or pancreatic cancer\n  * No known familial predisposition to biliary tract or pancreatic cancers\n  * No opposition to data reuse\n\nExclusion Criteria:\n\n* Incomplete or non-exploitable occupational history\n* Refusal of data reuse","ALL","18 Years",{"count":45,"type":46},210,"ESTIMATED","OBSERVATIONAL","PANTOXBIL is a research project developed in the context of the increasing incidence of biliary tract and pancreatic cancers in France. Despite recent therapeutic advances, the prognosis of these cancers remains poor. Known risk factors do not fully explain the increase in incidence observed over recent decades. This suggests the possible role of emerging occupational and environmental risk factors, as reported in several epidemiological studies.\n\nThe PANTOXBIL study is based on the analysis of detailed curriculum laboris data (employment periods, occupations, tasks performed, and occupational exposures) collected during two multicenter phase II clinical trials, TEDOPAM and IMMUNOBIL, conducted between 2018 and 2021 in patients with pancreatic and biliary tract cancers.\n\nAn occupational exposure assessment was performed to calculate semi-quantitative cumulative exposure indices for each exposure or group of exposures for every participant. These indices will be compared with those of healthy controls from the CHOPPI cohort, initially designed to study occupational risk factors in COPD.\n\nPANTOXBIL is a matched case-control study based on sex, age, and smoking status. The aim is to compare cumulative occupational exposure indices between cases and controls in order to generate new hypotheses regarding occupational risk factors for biliary tract and pancreatic cancers.",[50,51],"Biliary Tract Cancer","Pancreatic Cancer",[53,54,55,56,57],"Biliopancreatic cancers","Occupational exposure","Cumulative exposure index","Curriculum laboris","Case-control study","NOT_YET_RECRUITING","2026-06-19",{"date":61,"type":62},"2026-06-25","ACTUAL",{"date":64,"type":46},"2026-08",{"date":66,"type":46},"2026-09",{"name":5,"class":6}]