[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100420031":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":42,"studyPopulation":43,"armGroups":44,"interventions":50,"overallOfficials":38,"centralContacts":38,"locations":56,"responsibleParty":285,"collaborators":38,"id":287,"slug":38,"hasResults":288,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":288,"sex":294,"minAge":295,"maxAge":38,"enrollmentInfo":296,"targetDuration":38,"studyType":299,"phases":38,"briefSummary":300,"conditions":301,"keywords":38,"overallStatus":180,"whyStopped":38,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":312},{"fullName":5,"class":6},"Italian Sarcoma Group","NETWORK",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":38},[9,13],{"measure":10,"description":11,"timeFrame":12},"Treatments received for breast sarcoma","To describe treatment that patient diagnosed with breast sarcoma, received","At diagnosis (baseline) and after 6, 12, 18, 24, 36, 48 and 60 weeks",{"measure":14,"description":15,"timeFrame":16},"Number of patients with primary breast sarcoma","Number of patient with a diagnosis of primary breast sarcoma","Through study inclusion period, an average of 20 years",[18,20,24,27,31,35],{"measure":19,"description":19,"timeFrame":16},"Number of patients with primary breast sarcoma symptoms",{"measure":21,"description":22,"timeFrame":23},"Local-regional Relapse Free Survival (LRFS)","Time elapsed form the treatment (any) start and the onset of Local-regional relapse","Every 3 months (Month 3, Month 6, Month 9...) up to 5 years",{"measure":25,"description":26,"timeFrame":23},"Progression Free Survival (PFS)","Time elapsed form the treatment (any) start and the onset of progression",{"measure":28,"description":29,"timeFrame":30},"Overall Survival (OS)","Time elapsed for the diagnosis to the death for any cause","at 5 years",{"measure":32,"description":33,"timeFrame":34},"Median time of secondary breast sarcoma presentation","To define the median time to secondary sarcoma presentation","Up to 3 years",{"measure":36,"description":37,"timeFrame":34},"Impact of upfront multidisciplinary tumor board consultation","To describe the impact of upfront multidisciplinary tumor board consultation on outcomes",null,{"allocation":38,"interventionModel":38,"interventionModelDescription":38,"primaryPurpose":38,"observationalModel":40,"timePerspective":41,"maskingInfo":38},"COHORT","RETROSPECTIVE","In the field of soft tissue sarcomas, breast sarcomas are a truly peculiar family of rare tumors for both their clinical history and biology of disease.\n\nSurgery (if feasible) is the main therapeutic approach for all the patients with localized disease, while a pharmacological (chemotherapeutic) and\u002For radiotherapeutic treatment is reserved to those with high-risk\u002Frecurrent-relapsing\u002Fmetastatic disease.\n\nUnfortunately, there is a lack of specific prospective trials in breast sarcoma to guide the clinical decision-making and breast sarcoma patients are often sent to sarcoma referral centers only after surgery Due to sarcoma-specific clinical features, it is clear that both diagnostic and clinical strategies mandate a different approach compared to epithelial tumors. This is of key importance to reach the correct diagnosis, design the best therapeutic decision-making and subsequent follow-up.\n\nEven if retrospective data limitations and biases, in the lack of prospective data collection, these data may be a unique and precious source of information For this reasons this multi-institutional retrospective study is aimed to identify the most relevant clinical characteristics, treatment strategies, to explore the impact on principal clinical outcomes and finally, to suggest some principles for management and treatment of breast sarcomas.","Patients affected by breast sarcma referred to participating Institutions between January 2000 and June 2020.",[45],{"label":46,"type":38,"description":47,"interventionNames":48},"Breast sarcoma","This cohort include patients affected by breast sarcoma, referred to participating Institutions between January 2000 and June 2020.",[49],"Other: Treatment of Breast Sarcoma according clinical practice (includes drugs, surgery or any other received treatments)",[51],{"type":52,"name":53,"description":54,"armGroupLabels":55,"otherNames":38},"OTHER","Treatment of Breast Sarcoma according clinical practice (includes drugs, surgery or any other received treatments)","This observational study collects all the treatments received by the patients according clinical practices or experimental trials and therefore includes drug\u002Fbiological\u002Fsurgical and any other applicable treatments\n\nReorder Outcome Measures",[46],[57,79,95,110,129,147,162,178,196,212,227,242,255,270],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Azienda Ospedaliera S. Orsola-Malpighi","NOT_YET_RECRUITING","Bologna","BO","40138","Italy","IT",{"type":66,"coordinates":67},"Point",[68,69],11.33875,44.49381,{"lat":69,"lon":68},[72,77],{"name":73,"role":74,"phone":75,"phoneExt":38,"email":76},"Maria Abbondanza Pantaleo, MD","CONTACT","+39 051 2144043","maria.pantaleo@unibo.it",{"name":73,"role":78,"phone":38,"phoneExt":38,"email":38},"PRINCIPAL_INVESTIGATOR",{"facility":80,"status":59,"city":81,"state":82,"zip":83,"country":63,"countryCode":64,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Istituto Europeo di Oncologia","Milan","MI","20141",{"type":66,"coordinates":85},[86,87],12.59836,42.78235,{"lat":87,"lon":86},[90,94],{"name":91,"role":74,"phone":92,"phoneExt":38,"email":93},"Tommaso M. De Pas, MD","+390257489482","tommaso.de-pas@ieo.it",{"name":91,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":96,"status":59,"city":97,"state":82,"zip":98,"country":63,"countryCode":64,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Istituto Clinico Humanitas","Rozzano","20089",{"type":66,"coordinates":100},[101,102],9.1559,45.38193,{"lat":102,"lon":101},[105,109],{"name":106,"role":74,"phone":107,"phoneExt":38,"email":108},"Alexia Bertuzzi, MD","+390282244540","alexia.bertuzzi@cancercenter.humanitas.it",{"name":106,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":111,"status":59,"city":112,"state":113,"zip":114,"country":63,"countryCode":64,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"Azienda Ospedaliera Universitaria Paolo Giaccone","Palermo","PA","90127",{"type":66,"coordinates":116},[117,118],13.3636,38.1166,{"lat":118,"lon":117},[121,126,128],{"name":122,"role":74,"phone":123,"phoneExt":124,"email":125},"Giuseppe Badalamenti, MD","0039091655","4513","giuseppebadalamenti@unipa.it",{"name":127,"role":74,"phone":38,"phoneExt":38,"email":38},"Badalamenti",{"name":122,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":130,"status":59,"city":131,"state":132,"zip":133,"country":63,"countryCode":64,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Centro di Riferimento Oncologico - Unit of Medical Oncology","Aviano","Pordenone","33081",{"type":66,"coordinates":135},[136,137],12.59472,46.07056,{"lat":137,"lon":136},[140,143,145],{"name":141,"role":74,"phone":38,"phoneExt":38,"email":142},"Angela Buonadonna, MD","abuonadonna@cro.it",{"name":144,"role":74,"phone":38,"phoneExt":38,"email":38},"Angela, MD",{"name":141,"role":146,"phone":38,"phoneExt":38,"email":38},"SUB_INVESTIGATOR",{"facility":148,"status":59,"city":149,"state":150,"zip":151,"country":63,"countryCode":64,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Ospedale Misericordia e Dolce","Prato","PO","59100",{"type":66,"coordinates":153},[154,155],11.09699,43.8805,{"lat":155,"lon":154},[158,161],{"name":159,"role":74,"phone":38,"phoneExt":38,"email":160},"Giacomo G. Baldi, MD","ggbaldi@usl4.toscana.it",{"name":159,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":163,"status":59,"city":164,"state":165,"zip":166,"country":63,"countryCode":64,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"Policlinico Universitario Campus Biomedico","Roma","RM","00128",{"type":66,"coordinates":168},[169,170],11.10642,44.99364,{"lat":170,"lon":169},[173,177],{"name":174,"role":74,"phone":175,"phoneExt":38,"email":176},"Bruno Vincenzi, MD","+3902225411123","b.vincenzi@unicampus.it",{"name":174,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":179,"status":180,"city":181,"state":182,"zip":183,"country":63,"countryCode":64,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Fondazione del Piemonte per l'Oncologia IRCC Candiolo","RECRUITING","Candiolo","Torino","10060",{"type":66,"coordinates":185},[186,187],7.59812,44.95858,{"lat":187,"lon":186},[190,195],{"name":191,"role":74,"phone":192,"phoneExt":193,"email":194},"Giovanni Grignani, MD","39 (011) 993","3623","giovanni.grignani@ircc.it",{"name":191,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":197,"status":59,"city":198,"state":199,"zip":38,"country":63,"countryCode":64,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Ospedale Umberto I","Turin","TO",{"type":66,"coordinates":201},[202,203],7.68682,45.07049,{"lat":203,"lon":202},[206,211],{"name":207,"role":74,"phone":208,"phoneExt":209,"email":210},"Nicoletta Biglia","039 0115082","682","nicoletta.biglia@unito.it",{"name":207,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":213,"status":59,"city":214,"state":38,"zip":38,"country":63,"countryCode":64,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"A.O Ospedali Riuniti Marche Nord","Ancona",{"type":66,"coordinates":216},[217,218],13.5103,43.60717,{"lat":218,"lon":217},[221,226],{"name":222,"role":74,"phone":223,"phoneExt":224,"email":225},"Raffaella Bracci, MD","039 0721 36","11","raffaella.bracci@ospedalimarchenord.it",{"name":222,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":228,"status":59,"city":229,"state":38,"zip":230,"country":63,"countryCode":64,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Azienda Ospedaliera Universitaria Careggi","Florence","50100",{"type":66,"coordinates":232},[233,234],11.24626,43.77925,{"lat":234,"lon":233},[237,241],{"name":238,"role":74,"phone":239,"phoneExt":38,"email":240},"Silvia Gasperoni, MD","39 055 7949648","gasperoni.silvia@gmail.com",{"name":238,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":243,"status":59,"city":81,"state":38,"zip":244,"country":63,"countryCode":64,"cosmosGeoPoint":245,"geoPoint":247,"contacts":248},"Fondazione IRCCS INT Milano","20133",{"type":66,"coordinates":246},[86,87],{"lat":87,"lon":86},[249,254],{"name":250,"role":74,"phone":251,"phoneExt":252,"email":253},"Silvia Stacchiotti, MD","+39022390","2804","silvia.stacchiotti@istitutotumori.mi.it",{"name":250,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":256,"status":59,"city":164,"state":38,"zip":257,"country":63,"countryCode":64,"cosmosGeoPoint":258,"geoPoint":260,"contacts":261},"Istituto Nazionale Tumori Regina Elena - Unit of Medical Oncology I","00144",{"type":66,"coordinates":259},[169,170],{"lat":170,"lon":169},[262,267,269],{"name":263,"role":74,"phone":264,"phoneExt":265,"email":266},"Virginia Ferraresi, MD","+390652666","773","ferraresi@ifo.it",{"name":268,"role":74,"phone":38,"phoneExt":38,"email":38},"MD",{"name":263,"role":78,"phone":38,"phoneExt":38,"email":38},{"facility":271,"status":59,"city":182,"state":38,"zip":272,"country":63,"countryCode":64,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"ASL Città di Torino (Dipartimento di Oncologia)","10153",{"type":66,"coordinates":274},[275,276],11.99138,44.88856,{"lat":276,"lon":275},[279,282,284],{"name":280,"role":74,"phone":38,"phoneExt":38,"email":281},"Antonella Boglione, MD","antonella.boglione@aslcittaditorino.it",{"name":283,"role":74,"phone":38,"phoneExt":38,"email":38},"Boglione, MD",{"name":280,"role":78,"phone":38,"phoneExt":38,"email":38},{"type":286,"investigatorFullName":38,"investigatorTitle":38,"investigatorAffiliation":38,"oldNameTitle":38,"oldOrganization":38},"SPONSOR","100420031",false,"NCT04749446","Study on Clinical Features and Outcomes of Breast Sarcoma","Breast Sarcomas: A Retrospective Analysis of Clinical Features and Outcomes","Breast-Sarc","Inclusion Criteria:\n\n* \\>18 years at diagnosis\n* primary or secondary breast sarcoma\n* availability of medical data needed for the study (histopathological data, surgery, chemotherapy, including preceding chemotherapeutic regimens for secondary breast sarcomas, radiation therapy)\n\nExclusion Criteria:\n\n* sarcoma metastases to the breast\n* chest wall sarcomas not arising in the mammary gland\n* cutaneous sarcomas","ALL","19 Years",{"count":297,"type":298},300,"ESTIMATED","OBSERVATIONAL","This is multi-institutional retrospective study in order to identify the most relevant clinical characteristics, treatment strategies, to explore the impact on principal clinical outcomes and finally, to suggest some principles for management and treatment of breast sarcomas.\n\nThe study will collect data about patients affected by breast sarcoma referred to participating Institutions between January 2000 and June 2020",[302],"Breast Sarcoma","2025-12-30",{"date":305,"type":306},"2026-01-02","ACTUAL",{"date":308,"type":306},"2021-04-02",{"date":310,"type":298},"2026-12-01",{"name":5,"class":6},14]