[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582858":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":28,"locations":33,"responsibleParty":49,"collaborators":22,"id":51,"slug":22,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":22,"enrollmentInfo":60,"targetDuration":22,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":22,"overallStatus":36,"whyStopped":22,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"cases","topical treatment with the pre- and postbiotic and niacinamide 4% study preparation",[12],"Other: topical treatment with the pre- and postbiotic study preparation and niacinamide 4% and one with the 10% urea-based preparation.",{"label":14,"type":6,"description":15,"interventionNames":16},"control","prepared from 10% urea.",[12],[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"topical treatment with the pre- and postbiotic study preparation and niacinamide 4% and one with the 10% urea-based preparation.","Application of the topical preparation in both groups will be performed twice a day for a total duration of 3 months.",[9,14],null,[24],{"name":25,"affiliation":26,"role":27},"Ketty MD Peris","IRCCS FONDAZIONE POLICLINICO GEMELLI","PRINCIPAL_INVESTIGATOR",[29],{"name":25,"role":30,"phone":31,"phoneExt":22,"email":32},"CONTACT","0630154211","ketty.peris@unicatt.it",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Irccs Fondazione Policlinico Gemelli","RECRUITING","Roma","ROMA","00168","Italy",{"type":42,"coordinates":43},"Point",[44,45],11.10642,44.99364,{"lat":45,"lon":44},[48],{"name":25,"role":30,"phone":31,"phoneExt":22,"email":32},{"type":50,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100582858",false,"NCT06868771","Study on the Effectiveness of an Emollient Cream Containing Pre and Postbiotic and Niacinamide 4% in the Treatment of Skin Xerosis and Itching in Oncological Patients Treated with Anti-EGFR","Studio Sulla Efficacia Di Una Crema Emolliente Contenente Pre E Postbiotici E Niacinamide 4% Nel Trattamento Della Xerosi Cutanea E Del Prurito in Pazienti Oncologici in Trattamento Con Anti-EGFR","PENSANTE","Inclusion Criteria:\n\n1. patients aged 18 who have been receiving anti-EGFR therapy for more than three months,\n2. signature of the informed consent.\n\nExclusion Criteria:\n\n1. Patients diagnosed with Grade II papulopustulous skin reaction according to the Common Terminology Criteria for Adverse Event (CTCAE) scale at the time of enrolment;\n2. concomitant use of emollients and\u002For steroidal creams;\n3. personal history of xerotic pathologies (e.g. lichen, ichthyosis) and\u002For itching of n.d.d.;\n4. inability to provide informed consent or inability to complete the procedures required for enrollment in the study.","ALL","18 Years",{"count":61,"type":62},164,"ESTIMATED","INTERVENTIONAL",[65],"NA","Study on the Effectiveness of an Emollient Cream Containing Pre and Postbiotic and Niacinamide 4% in the Treatment of Skin Xerosis and Itching in Oncological Patients Treated With Anti-EGFR.",[68],"Xerosis Cutis","2025-03-04",{"date":71,"type":72},"2025-03-11","ACTUAL",{"date":74,"type":72},"2022-07-29",{"date":76,"type":62},"2025-04-30",{"name":5,"class":6},1]