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Sciences","Belgrade","11000","Serbia","RS",{"type":91,"coordinates":92},"Point",[93,94],20.46513,44.80401,{"lat":94,"lon":93},{"type":97,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100624471",false,"NCT07410065","Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight","Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight (HOPE)","HOPE","Inclusion Criteria:\n\n* Age \\> 18 years\n* Body mass index \\> 25.0 kg\u002Fm2 (persisted for at least six months before screening)\n* Stable on their therapy (if any) for ≥ 3 months\n* Free of acute disorders and severe chronic diseases\n* Informed consent signed\n* Normal fasting breath hydrogen levels \\\u003C 15 ppm\n\nExclusion Criteria:\n\n* History of dietary supplement use 4 weeks before the study commences\n* Abnormal values for lab clinical chemistry not related with stiyd outcomes (\\> 2 SD)\n* No consent to randomization\n* Unwillingness to return for follow-up analysis\n* Participation in other clinical trials\n* Participants starting or changing major treatments during the study period",true,"ALL","18 Years",{"count":109,"type":110},120,"ESTIMATED","INTERVENTIONAL",[113],"NA","The Supersaturated Hydrogen-Rich Water for Outpatients with Persistent Excess Weight (HOPE) study is a Phase III, multicenter, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of daily consumption of supersaturated hydrogen-rich water in adults with persistent excess body weight. The trial investigates whether sustained exposure to molecular hydrogen can favorably influence body composition and key metabolic outcomes compared with a placebo water lacking dissolved hydrogen. By enrolling outpatients across multiple centers and applying rigorous blinding and randomization procedures, HOPE aims to generate high-quality clinical evidence on the potential role of hydrogen-rich water as a non-pharmacological, adjunctive strategy for weight management and metabolic health.",[116],"Overweight",[118,119],"Metabolism","Hydrogen","NOT_YET_RECRUITING","2026-02-07",{"date":123,"type":124},"2026-02-13","ACTUAL",{"date":126,"type":110},"2026-04-15",{"date":128,"type":110},"2027-02-15",{"name":5,"class":6},1]