[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643219":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":36,"studyPopulation":37,"armGroups":38,"interventions":75,"overallOfficials":99,"centralContacts":104,"locations":109,"responsibleParty":120,"collaborators":32,"id":122,"slug":32,"hasResults":123,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":123,"sex":129,"minAge":130,"maxAge":32,"enrollmentInfo":131,"targetDuration":32,"studyType":134,"phases":32,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":143,"whyStopped":32,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":153},{"fullName":5,"class":6},"Antalya Health Sciences University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":32},[9],{"measure":10,"description":11,"timeFrame":12},"Determining the diagnostic accuracy of PIV","PIV (pan-immune-inflammation value)","Postoperative 1 month",[14,17,20,23,26,29],{"measure":15,"description":16,"timeFrame":12},"Determining the diagnostic accuracy of NLR","NLR (neutrophil-lymphocyte ratio)",{"measure":18,"description":19,"timeFrame":12},"Determining the diagnostic accuracy of PLR","PLR (platelet-lymphocyte ratio)",{"measure":21,"description":22,"timeFrame":12},"Determining the diagnostic accuracy of HEO","HEO (hemoglobin-eosinophil ratio)",{"measure":24,"description":25,"timeFrame":12},"Determining the diagnostic accuracy of SII","SII (systemic immune-inflammation index)",{"measure":27,"description":28,"timeFrame":12},"Determining the diagnostic accuracy of NPAR","NPAR (neutrophil-albumin ratio)",{"measure":30,"description":31,"timeFrame":12},"Determining the diagnostic accuracy of HALP","HALP (hemoglobin, albumin, platelet ratio)",null,{"allocation":32,"interventionModel":32,"interventionModelDescription":32,"primaryPurpose":32,"observationalModel":34,"timePerspective":35,"maskingInfo":32},"CASE_CONTROL","RETROSPECTIVE","Benign laryngeal lesions are generally nodules, polyps, or cysts that form due to overuse of the voice or vocal cord trauma. Reinke's edema, also within this group, is a benign laryngeal condition characterized by the accumulation of gelatinous fluid in the superficial lamina propria of the vocal cords. It is usually associated with chronic irritation, particularly smoking, and is frequently seen in middle-aged individuals with a long history of tobacco use. Previous experimental studies have shown that cigarette smoke triggers inflammatory responses in vocal cord fibroblasts and increases the production of inflammatory mediators. The cellular and systemic inflammatory processes triggered by irritation due to chronic smoking are still not fully understood. In recent years, systemic inflammation markers derived from routine hemogram parameters have attracted attention as low-cost and reliable potential biomarkers in various inflammatory and neoplastic diseases. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), hemoglobin-eosinophil ratio (HEO), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV), as well as more comprehensive indices reflecting both inflammatory and nutritional status such as Neutrophil-Albumin Ratio (NPAR) and HALP (Hemoglobin, Albumin, Platelet Ratio), are inexpensive and readily available indicators of systemic inflammation. However, a review of the literature reveals a lack of studies examining the relationship between benign and malignant laryngeal lesions and systemic inflammation through these comprehensive indices (PIV and NPAR). The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.","Inclusion was planned for patients aged 18 and over, with a diagnosis of vocal cord lesion via endoscopic or surgical means, and with complete blood count and albumin data in hospital records.",[39,43,47,51,55,59,63,67,71],{"label":40,"type":32,"description":32,"interventionNames":41},"Laryngeal polyps",[42],"Other: Laryngeal polyps",{"label":44,"type":32,"description":32,"interventionNames":45},"Laryngeal nodules",[46],"Other: Laryngeal nodules",{"label":48,"type":32,"description":32,"interventionNames":49},"Laryngeal cysts",[50],"Other: Laryngeal cysts",{"label":52,"type":32,"description":32,"interventionNames":53},"Reinke's edema",[54],"Other: Reinke's edema",{"label":56,"type":32,"description":32,"interventionNames":57},"Papillomas",[58],"Other: Papillomas",{"label":60,"type":32,"description":32,"interventionNames":61},"Dysplasia",[62],"Other: Dysplasia",{"label":64,"type":32,"description":32,"interventionNames":65},"High-risk premalignant lesions",[66],"Other: High-risk premalignant lesions",{"label":68,"type":32,"description":32,"interventionNames":69},"Malignant vocal cord lesions",[70],"Other: Malignant vocal cord lesions",{"label":72,"type":32,"description":32,"interventionNames":73},"Control",[74],"Other: Asymptomatic smokers without vocal cord lesions",[76,79,81,83,85,88,90,92,95],{"type":6,"name":40,"description":77,"armGroupLabels":78,"otherNames":32},"Bening laryngeal lesions",[40],{"type":6,"name":44,"description":77,"armGroupLabels":80,"otherNames":32},[44],{"type":6,"name":48,"description":77,"armGroupLabels":82,"otherNames":32},[48],{"type":6,"name":52,"description":77,"armGroupLabels":84,"otherNames":32},[52],{"type":6,"name":56,"description":86,"armGroupLabels":87,"otherNames":32},"Premalign laryngeal lesions",[56],{"type":6,"name":60,"description":86,"armGroupLabels":89,"otherNames":32},[60],{"type":6,"name":64,"description":86,"armGroupLabels":91,"otherNames":32},[64],{"type":6,"name":68,"description":93,"armGroupLabels":94,"otherNames":32},"Malign laryngeal lesions",[68],{"type":6,"name":96,"description":97,"armGroupLabels":98,"otherNames":32},"Asymptomatic smokers without vocal cord lesions","None laryngeal lesions",[72],[100],{"name":101,"affiliation":102,"role":103},"Nuray Ensari","University of Health Sciences, Antalya Training and Research Hospital","PRINCIPAL_INVESTIGATOR",[105],{"name":101,"role":106,"phone":107,"phoneExt":32,"email":108},"CONTACT","+905055025177","nurayakmese@yahoo.com",[110],{"facility":102,"status":32,"city":111,"state":112,"zip":32,"country":113,"countryCode":32,"cosmosGeoPoint":114,"geoPoint":119,"contacts":32},"Antalya","Muratpaşa","Turkey (Türkiye)",{"type":115,"coordinates":116},"Point",[117,118],30.69556,36.90812,{"lat":118,"lon":117},{"type":121,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100643219",false,"NCT07626125","Systemic Inflammatory Markers In Vocal Cord Lesions","Comparison Of Sysstemic Inflammatory Markers And Panimmune-Inflammatory Values In Patients With Beningn, Premalingnant And Malingnant Vocal Cord Lesions","SILVCL","Inclusion Criteria:\n\n* Patients aged 18 years and older\n* Patients with a diagnosis of vocal cord lesion via endoscopic or surgical means\n* Patients with complete blood count and albumin data in their hospital records\n\nExclusion Criteria:\n\n* Acute infection\n* Autoimmune disease\n* Other malignancy\n* Steroid use\n* Hematological disease\n* Systemic inflammatory disease\n* Missing laboratory data","ALL","18 Years",{"count":132,"type":133},250,"ESTIMATED","OBSERVATIONAL","The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.",[137,138],"Laryngeal Lesions","Systemic Inflammatory Process",[140,141,142],"Laryngeal lesions","systemic inflammatory process","panimmun inflamation","NOT_YET_RECRUITING","2026-06-06",{"date":146,"type":147},"2026-06-09","ACTUAL",{"date":149,"type":133},"2026-05-22",{"date":151,"type":133},"2026-06-19",{"name":5,"class":6},1]