[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535217":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":23,"locations":33,"responsibleParty":51,"collaborators":54,"id":68,"slug":10,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":10,"maxAge":10,"enrollmentInfo":76,"targetDuration":10,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with immune dysregulation",null,"Patients sampled before and during different immunomodulatory therapies due to immune system dysregulation.",[13],"Combination Product: Immunomodulation",{"label":15,"type":10,"description":16,"interventionNames":10},"Healthy subjects","Age-matched healthy individuals sampled longitudinally",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"COMBINATION_PRODUCT","Immunomodulation","Variable protocols for combined immunomodulatory therapies currently in use for different forms of immune dysregulation",[9],[24,30],{"name":25,"role":26,"phone":27,"phoneExt":28,"email":29},"Petter Brodin, M.D., Ph.D","CONTACT","08 524 813 96","+46","petter.brodin@ki.se",{"name":31,"role":26,"phone":10,"phoneExt":10,"email":32},"Genia Kretzschmar, M.D","genia.kretzschmar@ki.se",[34],{"facility":5,"status":35,"city":36,"state":10,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Stockholm","SE171 77","Sweden",{"type":40,"coordinates":41},"Point",[42,43],18.06871,59.32938,{"lat":43,"lon":42},[46,49],{"name":47,"role":26,"phone":48,"phoneExt":10,"email":29},"Petter Brodin, MD PhD","+46 8 52481396",{"name":47,"role":50,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":50,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Petter Brodin","M.D., Ph.D., Professor",[55,57,59,61,63,65],{"name":56,"class":6},"Karolinska University Hospital",{"name":58,"class":6},"Skane University Hospital",{"name":60,"class":6},"Sahlgrenska University Hospital",{"name":62,"class":6},"Uppsala University Hospital",{"name":64,"class":6},"Region Halland",{"name":66,"class":67},"Region Jönköping County","OTHER_GOV","100535217",false,"NCT06248957","SYSTEMS-LEVEL ANALYSES OF IMMUNE DYSREGULATION","SAID","Inclusion Criteria:\n\nPatients of all ages seeking care or being referred for suspected immune dysregulation or with a known immune-mediated disease and failing to respond to standard therapy\n\nExclusion Criteria:\n\nHealthy control individuals will be excluded on the basis of having a diagnosis of an immune mediated disorder, immunomodulatory treatment or current infection or cancer.",true,"ALL",{"count":77,"type":78},500,"ESTIMATED","OBSERVATIONAL","The aim of the SAID study is to create a national resource in Sweden to enable comprehensive immunological analyses of an extremely complex and clinically challenging group of individuals with variable forms of immune system dysregulation. We hope to establish a biobank of primarily blood and fecal samples from children and adults, with confirmed or suspected immune dysregulation, as well as age- and sex- matched healthy controls, for comparisons of immune cell\u002Fmediator alongside various clinical presentations of these immunological diseases as well as microbiome samples as possible a possible modifier of clinical presentations. The project will also include the establishment of a national database with deep immunological data, treatment and clinical outcomes for these patients, accessible to participating researchers and clinicians.",[82,83,84,85,86],"Immunodeficiency","Autoimmune Diseases","Autoinflammatory Syndrome","Allergy","Dysregulated Host Response","2024-01-31",{"date":89,"type":90},"2024-02-08","ACTUAL",{"date":92,"type":90},"2024-01-01",{"date":94,"type":78},"2031-12-31",{"name":5,"class":6},1]