[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627353":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":36,"centralContacts":40,"locations":46,"responsibleParty":64,"collaborators":44,"id":68,"slug":44,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":44,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":44,"enrollmentInfo":76,"targetDuration":44,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":44,"overallStatus":49,"whyStopped":44,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Iowa","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diagnostic (T2* MRI, blood sample collection)","EXPERIMENTAL","Patients undergo T2\\* MRI over 10 minutes and blood sample collection during radiation therapy simulation, weekly during radiation therapy, and at 1- and 3- months post-radiation therapy in the absence of unacceptable toxicity. Patients also undergo standard MRI throughout the study.",[13,14,15],"Procedure: T2 (Observed)-Weighted Imaging","Procedure: Biospecimen Collection","Procedure: Magnetic Resonance Imaging",[17,24,30],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","T2 (Observed)-Weighted Imaging","Undergo T2\\* MRI",[9],[23],"T2*-Weighted Imaging, T2*MRI, T2*WI",{"type":18,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Biospecimen Collection","Undergo blood sample collection",[9],[29],"Biological Sample Collection, Biological Sample Collection, Biospecimen Collected, Biospecimen Collection, Specimen Collection",{"type":18,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Magnetic Resonance Imaging","Undergo standard MRI",[9],[35],"Magnetic Resonance, Magnetic Resonance Imaging, Magnetic Resonance Imaging, Magnetic Resonance Imaging, magnetic resonance imaging, Magnetic Resonance Imaging, Magnetic Resonance Imaging",[37],{"name":38,"affiliation":5,"role":39},"John Buatti, MD","PRINCIPAL_INVESTIGATOR",[41],{"name":38,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","(319) 356-7590",null,"john-buatti@uiowa.edu",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University of Iowa Health Care","RECRUITING","Iowa City","Iowa","52245","United States",{"type":55,"coordinates":56},"Point",[57,58],-91.53017,41.66113,{"lat":58,"lon":57},[61,63],{"name":38,"role":42,"phone":62,"phoneExt":44,"email":45},"319-356-7590",{"name":38,"role":42,"phone":43,"phoneExt":44,"email":45},{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"SPONSOR_INVESTIGATOR","John M. Buatti","Professor","100627353",false,"NCT07447531","T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas","Evaluating Iron-Dependent Biomarkers of Malignant Glioma (WHO Grade IV) Progression","Inclusion Criteria:\n\n* Age \\> 21 years\n* New pathologically confirmed diagnosis of WHO grade IV malignant glioma\n* KPS \\> 60\n* Ability to give informed consent for standard of care chemotherapy and radiation therapy on the MR Linac and to study procedures for the protocol\n\nExclusion Criteria:\n\n* History of previous malignancy other than non-melanoma skin cancer in the previous 5 years\n* History of iron metabolic disorder such as hemochromatosis\n* Inability to undergo MR studies due to size, claustrophobia, or metal implants or devices","ALL","21 Years",{"count":77,"type":78},15,"ESTIMATED","INTERVENTIONAL",[81],"NA","This clinical trial studies whether T2 star (T2\\*) magnetic resonance imaging (MRI) and biomarker blood testing can help predict how World Health Organization (WHO) grade IV gliomas (malignant gliomas) might change or progress over time.",[84],"Malignant Glioma","2026-02-25",{"date":87,"type":88},"2026-03-03","ACTUAL",{"date":90,"type":88},"2025-10-03",{"date":92,"type":78},"2028-10-06",{"name":66,"class":6},1]