[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100475646":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":34,"responsibleParty":50,"collaborators":10,"id":52,"slug":10,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":65,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"National Taiwan University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Genetic group",null,"Patients who have positive DNA results by NGS screening of the following 5 genes: NOTCH3 (19q13.12), HTRA1 (10q26.13), GLA (Xq22.1), TREX1 (3p1.31) and COL4A1 (13q34).",[13],"Diagnostic Test: MRI",{"label":15,"type":10,"description":16,"interventionNames":17},"Nongenetic group","Patients who have negative DNA results by NGS screening .",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","MRI","Patients will repeat study-protocol MRI at baseline (enrollment) and at least once in 1 year or 2 years follow-up (depends on availability).",[9,15],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Sung-Chun Tang, MD, PhD","CONTACT","886972651113","sctang@ntuh.gov.tw",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Chih-Hao Chen, MD, PhD","886987392027","antonychen@ntu.edu.tw",[35],{"facility":36,"status":37,"city":38,"state":10,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Department of Neurology, National Taiwan University Hospital","RECRUITING","Taipei","100","Taiwan",{"type":42,"coordinates":43},"Point",[44,45],121.52639,25.05306,{"lat":45,"lon":44},[48,49],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100475646",false,"NCT05473637","Taiwan Associated Genetic and Nongenetic Small Vessel Disease","Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases","TAG-SVD","Inclusion Criteria:\n\nParticipants must have at least one of the following symptoms\u002Fsigns or history\n\n* stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke)\n* cognitive impairment or dementia\n* gait disturbance\n* parkinsonism (especially vascular parkinsonism features)\n* headache (especially migraine)\n* positive family history of hereditary CSVD\n* MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed\n\nExclusion Criteria:\n\n* MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions\n* patients or family members not willing to sign informed consent",true,"ALL","18 Years",{"count":63,"type":64},500,"ESTIMATED","2 Years","OBSERVATIONAL","The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.",[69,70,71,72,73,74,75,76],"Cerebral Small Vessel Diseases","Cadasil","HTRA1-Related Autosomal Dominant Cerebral Angiopathy","COL4A1-Related Brain Small Vessel Disease With Haemorrhage","Fabry Disease","Magnetic Resonance Imaging","Next-generation Sequencing","Stroke","2026-01-15",{"date":79,"type":80},"2026-01-20","ACTUAL",{"date":82,"type":80},"2019-01-01",{"date":84,"type":64},"2028-12-31",{"name":5,"class":6},1]