[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641092":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":44,"collaborators":11,"id":48,"slug":11,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":11,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":11,"enrollmentInfo":56,"targetDuration":11,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":11,"overallStatus":65,"whyStopped":11,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"tDCS in older adults with LLD","EXPERIMENTAL",null,[13],"Device: High-intensity (6 mA) transcranial direct current stimulation (tDCS)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DEVICE","High-intensity (6 mA) transcranial direct current stimulation (tDCS)","High-intensity (6 mA), spaced (three daily sessions, 3 times a week, for 3 weeks) transcranial direct current stimulation (tDCS) in older adults (60 y\u002Fo and over) with Late-Life Depression",[9],[21],{"name":22,"affiliation":5,"role":23},"Andre Russowsky Brunoni, MD PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},"Clinical Research Coordinator","CONTACT","214-645-2991","alexus.washington@utsouthwestern.edu",[31],{"facility":5,"status":11,"city":32,"state":33,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Dallas","Texas","75390","United States",{"type":37,"coordinates":38},"Point",[39,40],-96.80667,32.78306,{"lat":40,"lon":39},[43],{"name":22,"role":23,"phone":11,"phoneExt":11,"email":11},{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Andre Russowsky Brunoni","Professor and Chief of the Division of Interventional Psychiatry Department of Psychiatry UT Southwestern Medical Center Peter O'Donnell Jr. Brain Institute","100641092",false,"NCT07657234","tDCS for Late-Life Depression","High-Dose Spaced Bilateral tDCS for Late-Life Depression: Open-Label Pilot Study","Inclusion Criteria:\n\nParticipants must meet all of the following criteria:\n\n1. age 60 years or older;\n2. diagnosis of unipolar major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by the Mini International Neuropsychiatric Interview (MINI);\n3. score of 17 or higher on the 17-item Hamilton Depression Rating Scale (HDRS-17) at screening;\n4. stable antidepressant regimen for at least four weeks prior to enrollment, if applicable;\n5. capacity to provide informed consent;\n6. Clinical Dementia Rating scale of 0 or 0.5.\n\nExclusion Criteria:\n\nParticipants meeting any of the following criteria will be excluded:\n\n1. contraindications to tDCS including metallic cranial implants, skin conditions at electrode sites (eczema, open wounds, burns, lesions), or history of adverse reaction to tDCS;\n2. contraindications to magnetic resonance imaging (MRI) including pacemaker, cochlear implants, ferromagnetic implants, or claustrophobia;\n3. history of seizures or epilepsy;\n4. bipolar disorder, psychotic disorders, or severe personality disorder;\n5. dementia or MoCA score below 17;\n6. substance use disorder within the past six months;\n7. neuromodulation treatment including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), tDCS, or vagus nerve stimulation (VNS) within the past six months;\n8. active suicidal ideation with plan or intent requiring a higher level of care;\n9. concurrent use of medications that substantially lower seizure threshold;\n10. pregnancy.","ALL","60 Years",{"count":57,"type":58},20,"ESTIMATED","INTERVENTIONAL",[61],"NA","The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD).\n\nThe study will evaluate feasibility, safety, and tolerability of high-dose (6mA) bilateral tDCS delivered as three daily sessions, 3 times a week, for 3 weeks in older adults (60 y\u002Fo and older) with late-life depression.",[64],"Late Life Depression (LLD)","NOT_YET_RECRUITING","2026-06-12",{"date":68,"type":69},"2026-06-18","ACTUAL",{"date":71,"type":58},"2026-08",{"date":73,"type":58},"2027-09",{"name":46,"class":6},1]