[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530591":3},{"organization":4,"outcomesModule":7,"designInfo":35,"detailedDescription":34,"studyPopulation":34,"armGroups":46,"interventions":58,"overallOfficials":34,"centralContacts":64,"locations":70,"responsibleParty":87,"collaborators":34,"id":91,"slug":34,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":34,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":34,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":34,"overallStatus":73,"whyStopped":34,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"University of Copenhagen","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":21,"otherOutcomes":34},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Fiber cross-sectional area","Immunohistochemistry to determine fiber cross-sectional area","The change in fiber cross-sectional is assessed at baseline, 4, 20 and 24 weeks",{"measure":14,"description":15,"timeFrame":16},"Myonuclei","Immunohistochemistry to determine number of myonuclei","The change in myonuclei is assessed at baseline, 4, 20 and 24 weeks",{"measure":18,"description":19,"timeFrame":20},"Skeletal muscle proteome","Pathway enrichment analysis of the muscle proteome using mass spectrometry-based proteomics","The change in the muscle proteome is assessed at baseline, 4, 20 and 24 weeks",[22,26,30],{"measure":23,"description":24,"timeFrame":25},"Lean mass","Lean mass assessed by dual X-ray absorptiometry (DXA)","The change in lean mass is assessed at baseline, 4, 20 and 24 weeks",{"measure":27,"description":28,"timeFrame":29},"Satellite cells","Immunohistochemistry to determine number of satellite cells","The change in satellite cells is assessed at baseline, 4, 20 and 24 weeks",{"measure":31,"description":32,"timeFrame":33},"Muscle strength","1-repetition maximum","The change in 1-repetition maximum is assessed at baseline, 4, 20 and 24 weeks",null,{"allocation":36,"interventionModel":37,"interventionModelDescription":34,"primaryPurpose":38,"observationalModel":34,"timePerspective":34,"maskingInfo":39},"RANDOMIZED","PARALLEL","BASIC_SCIENCE",{"masking":40,"maskingDescription":34,"whoMasked":41},"QUADRUPLE",[42,43,44,45],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR",[47,53],{"label":48,"type":49,"description":50,"interventionNames":51},"Testosterone","EXPERIMENTAL","Participants are randomized to a single injection of 1000 mg testosterone undecanoate",[52],"Drug: Testosterone Undecanoate",{"label":54,"type":55,"description":56,"interventionNames":57},"Placebo","PLACEBO_COMPARATOR","Participants are randomized to a single placebo injection",[52],[59],{"type":60,"name":61,"description":62,"armGroupLabels":63,"otherNames":34},"DRUG","Testosterone Undecanoate","Following testosterone\u002Fplacebo injection, participants undergo supervised resistance training for 4 weeks. This period is followed by a washout period with no drug and either continued resistance training or detraining for 16 weeks. Thereafter, another 4-week period with supervised resistance training is commenced, with no drug.",[54,48],[65],{"name":66,"role":67,"phone":68,"phoneExt":34,"email":69},"Lukas Moesgaard","CONTACT","+4561724440","lm@nexs.ku.dk",[71],{"facility":72,"status":73,"city":74,"state":34,"zip":75,"country":76,"countryCode":77,"cosmosGeoPoint":78,"geoPoint":83,"contacts":84},"The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen","RECRUITING","Copenhagen","2100","Denmark","DK",{"type":79,"coordinates":80},"Point",[81,82],12.56553,55.67594,{"lat":82,"lon":81},[85],{"name":86,"role":67,"phone":68,"phoneExt":34,"email":69},"Lukas Moesgaard, MSc",{"type":88,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"SPONSOR_INVESTIGATOR","Morten Hostrup, PhD","Associate Professor","100530591",false,"NCT06188767","Testosterone-induced Muscle Memory and Underlying Mechanisms","Long-term Effects of Anabolic Androgenic Steroids on Muscle Growth Potential: Testosterone-induced Muscle Memory and Underlying Mechanisms","Inclusion Criteria:\n\n* Healthy men and women\n* BMI of \\\u003C26 and normal ECG and blood pressure\n\nExclusion Criteria:\n\n* Smoking\n* Chronic disease,\n* Use of prescription medication\n* Pain due to current or previous musculoskeletal injury\n* Resistance training more than once per week in the 12 months leading up to the intervention\n* Current or previous use of prohibited anabolic substances",true,"MALE","18 Years","40 Years",{"count":102,"type":103},30,"ESTIMATED","INTERVENTIONAL",[106],"NA","The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.",[109],"Skeletal Muscle Physiology","2025-04-07",{"date":112,"type":113},"2025-04-10","ACTUAL",{"date":115,"type":113},"2025-04-01",{"date":117,"type":103},"2028-12-01",{"name":89,"class":6},1]