[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578392":3},{"organization":4,"outcomesModule":7,"designInfo":20,"detailedDescription":23,"studyPopulation":24,"armGroups":25,"interventions":31,"overallOfficials":19,"centralContacts":19,"locations":19,"responsibleParty":37,"collaborators":19,"id":41,"slug":19,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":19,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":19,"studyType":53,"phases":19,"briefSummary":54,"conditions":55,"keywords":19,"overallStatus":57,"whyStopped":19,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":19},{"fullName":5,"class":6},"Attikon Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":19},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Endothelial glycocalyx","The association between time in range and the thickness of endothelial glycocalyx","Baseline",{"measure":14,"description":15,"timeFrame":12},"Pulse wave velocity","The association between time in range and pulse wave velocity",{"measure":17,"description":18,"timeFrame":12},"Global longitudinal strain","The association between time in range and global longitudinal strain",null,{"allocation":19,"interventionModel":19,"interventionModelDescription":19,"primaryPurpose":19,"observationalModel":21,"timePerspective":22,"maskingInfo":19},"COHORT","CROSS_SECTIONAL","In this observational study, 90 participants with T1D on MiniMed 780G system will be included. HbA1c, anthropometric measurements, CGM and Insulin Metrics will be assessed in all patients. Moreover, the investigators will assess:\n\n1. the pulse wave velocity, the augmentation index and the central systolic blood pressure which are markers of arterial stiffness\n2. the perfused boundary region of subglingulal vessels which is marker of endothelial function\n3. the global longitudinal strain which is marker of myocardial function.","patients aged \\>12 years old with T1DM who are on MiniMed 780G system .",[26],{"label":27,"type":19,"description":28,"interventionNames":29},"Type 1 Diabetes Mellitus","In this observaltional study, 90 patients aged \\>12 years old with T1DM who are on MiniMed 780G system will be included.We aim to investigate the association between markers of endothelial and cardiovascular function with with CGM and insulin metrics, as well as anthropometric measurements, BM, lipid levels, blood pressure.",[30],"Device: MiniMed 780G",[32],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":19},"DEVICE","MiniMed 780G","patients aged \\>12 years old with T1DM who are on MiniMed 780G",[27],{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","VAIA LAMBADIARI","Professor of Internal Medicine-Endocrinology","100578392",false,"NCT06810700","The Association Between Time in Range With Markers of Endothelial and Cardiovascular Function","The Association Between Time in Range With Markers of Endothelail an Dcardiovascular Function in Patients With type1 Diabetes Mellitus and Minimed 780G","Inclusion Criteria:\n\n1. Clinical diagnosis of type 1 diabetes \\>1 year prior to consent date. Diagnosis of type 1 diabetes is based on the investigator's judgment; C peptide level and antibody determinations are not required.\n2. HbA1c \\\u003C 12.5%\n3. Age \\>7years at the initiation of the system\n4. Multiple Daily Injections (Basal Bolus therapy) with Total daily insulin use of great than 8.0 units per day over a 1-week period\n5. Clinically able to start the AHCL system\n6. History of 3 clinic visits in the last year\n\nExclusion Criteria:\n\n1\\. Diabetic Ketoacidosis in the 6 months prior to screening visits","ALL","12 Years","80 Years",{"count":51,"type":52},90,"ESTIMATED","OBSERVATIONAL","In this observaltional study, 90 patients aged \\>12 years old with T1DM who are on MiniMed 780G system will be included.We aim to investigate the association between time in range (70-140mg\u002Fdl) and time in tight range (70-180mg\u002Fdl) with markers of endothelial and cardiovascular function.",[56],"Type 1 Diabetes","NOT_YET_RECRUITING","2025-02-04",{"date":60,"type":61},"2025-02-05","ACTUAL",{"date":63,"type":52},"2025-02-15",{"date":65,"type":52},"2025-09-15",{"name":5,"class":6}]