[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477408":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":20,"studyPopulation":21,"armGroups":22,"interventions":32,"overallOfficials":37,"centralContacts":46,"locations":54,"responsibleParty":84,"collaborators":86,"id":91,"slug":16,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":16,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":16,"studyType":104,"phases":16,"briefSummary":105,"conditions":106,"keywords":16,"overallStatus":57,"whyStopped":16,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Shanghai University of Traditional Chinese Medicine","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":16},[9,13],{"measure":10,"description":11,"timeFrame":12},"Difference in gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients","PCR test of gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients","Two year",{"measure":14,"description":15,"timeFrame":12},"Association of transgelin-2, metallothionein-2 and ezrin with asthma","Correlation analysis between gene expressions of transgelin-2, metallothionein-2, ezrin and current asthmatic tests (pulmonary function, fractional exhaled nitric oxide,immunoglobulin E, serum eosinophil counts, interleukin-5, etc)",null,{"allocation":16,"interventionModel":16,"interventionModelDescription":16,"primaryPurpose":16,"observationalModel":18,"timePerspective":19,"maskingInfo":16},"CASE_CONTROL","RETROSPECTIVE","This study will investigate the changes and associations in asthma. In this project, the investigators will explore the changes of gene expression of transgelin-2, metallothionein-2 and ezrin in asthma and investigate their correlation with current diagnosis markers of asthma, including pulmonary function, fractional exhaled nitric oxide,eosinophil counts,immunoglobulin E, interleukin-5, etc.","Participants with asthma or non-asthma",[23,28],{"label":24,"type":16,"description":25,"interventionNames":26},"Asthma","Previously disgnosed asthma patients",[27],"Diagnostic Test: No intervention",{"label":29,"type":16,"description":30,"interventionNames":31},"Control","Healthy participants",[27],[33],{"type":34,"name":35,"description":35,"armGroupLabels":36,"otherNames":16},"DIAGNOSTIC_TEST","No intervention",[24,29],[38,42],{"name":39,"affiliation":40,"role":41},"Lei-Miao Yin, MD","Yueyang Hospital, Shanghai University of Traditional Chinese medicine","STUDY_CHAIR",{"name":43,"affiliation":44,"role":45},"Jun-Tao Feng, MD","Xiangya Hospital of Central South University","STUDY_DIRECTOR",[47,51],{"name":39,"role":48,"phone":49,"phoneExt":16,"email":50},"CONTACT","13774384237","collegeylm@shutcm.edu.cn",{"name":43,"role":48,"phone":52,"phoneExt":16,"email":53},"13786145799","jtfeng1976@csu.edu.cn",[55,71],{"facility":56,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Xiangya Hospital, Central South University","RECRUITING","Changsha","Hunan","410000","China","CN",{"type":64,"coordinates":65},"Point",[66,67],112.97087,28.19874,{"lat":67,"lon":66},[70],{"name":43,"role":48,"phone":52,"phoneExt":16,"email":53},{"facility":72,"status":73,"city":74,"state":75,"zip":76,"country":61,"countryCode":62,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Yueyang Hospital, Shanghai University of Traditional Chinese Medicine","NOT_YET_RECRUITING","Shanghai","Shanghai Municipality","200030",{"type":64,"coordinates":78},[79,80],121.45806,31.22222,{"lat":80,"lon":79},[83],{"name":39,"role":48,"phone":49,"phoneExt":16,"email":50},{"type":85,"investigatorFullName":16,"investigatorTitle":16,"investigatorAffiliation":16,"oldNameTitle":16,"oldOrganization":16},"SPONSOR",[87,88],{"name":44,"class":6},{"name":89,"class":90},"National Natural Science Foundation of China","OTHER_GOV","100477408",false,"NCT05496582","The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma","The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma: A Case-control Study","Inclusion Criteria:\n\n1. Males or females, aged 14-75 years;\n2. Patients with a definite diagnosis of bronchial asthma;\n3. The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;\n4. Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;\n5. Agree with all procedures in this trial by signing a written informed consent form.\n\nExclusion Criteria:\n\n1. Patients with chronic obstructive pulmonary disease or other airway disease;\n2. Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;\n3. Women who are known to be pregnant or breastfeeding;\n4. Not willing to participate;\n5. Psychiatric history and neurological disorders can not work normally;\n6. Other conditions that the researcher considers inappropriate to participate in this study.",true,"ALL","14 Years","75 Years",{"count":102,"type":103},100,"ESTIMATED","OBSERVATIONAL","Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.",[24],"2024-05-06",{"date":109,"type":110},"2024-05-08","ACTUAL",{"date":112,"type":110},"2022-11-01",{"date":114,"type":103},"2026-12",{"name":5,"class":6},2]