[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500934":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":20,"interventions":26,"overallOfficials":20,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":20,"id":54,"slug":20,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":20,"eligibilityCriteria":58,"healthyVolunteers":55,"sex":59,"minAge":60,"maxAge":20,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":20,"briefSummary":65,"conditions":66,"keywords":20,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"University Hospital of Limerick","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":20},[9,13],{"measure":10,"description":11,"timeFrame":12},"Calcification feature classification","Identification of particular calcification features of plaque tissue and their influence on mechanical properties which may help clarify the success of stenting in certain patient cohorts compared to others and elucidate the procedural risk of endovascular treatments in plaque with certain calcification types.","10 years",{"measure":14,"description":15,"timeFrame":12},"Biomarker Analysis","Identification of novel biomarkers of vascular calcification could potentially be used as a predictive tool to highlight those at greatest risk of adverse peri-operative events, to allow for tailored medical treatment approaches and to stream-line patient care and improve patient outcomes.",[17],{"measure":18,"description":19,"timeFrame":12},"Cardiovascular Health Critical Mass","To build a critical mass in cardiovascular health, an area of strategic importance for healthcare in Ireland.",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"COHORT","PROSPECTIVE","The study is a non-randomised, controlled, cross-sectional study of diseased human carotid, femoral and abdominal aortic tissue.","Patients eligible for peripheral endarterectomy of the carotid\u002Ffemoral artery or abdominal aortic aneurysm surgery to remove artery blockage will be invited to take part in this study with no restrictions on patient type.",[27],{"type":6,"name":28,"description":28,"armGroupLabels":20,"otherNames":20},"No intervention.",[30],{"name":31,"role":32,"phone":33,"phoneExt":20,"email":34},"Fiona Leahy, MSc","CONTACT","061 301111","fionac.leahy@hse.ie",[36],{"facility":37,"status":38,"city":39,"state":39,"zip":20,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"University Hospital Limerick","RECRUITING","Limerick","Ireland","IE",{"type":43,"coordinates":44},"Point",[45,46],-8.62306,52.66472,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":20,"email":34},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Fiona Leahy","CNM II Research","100500934",false,"NCT05802706","The Biomechanical Study of Diseased Human Carotid, Femoral and Abdominal Aortic Tissue","Inclusion Criteria:\n\n* Patients with arterial plaque undergoing treatment where the plaque tissue will be surgically removed as per the usual peripheral endarterectomy procedure.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Patients that are unable to give informed consent.\n* Seriously ill\u002Funconscious patients.","ALL","18 Years",{"count":62,"type":63},300,"ESTIMATED","OBSERVATIONAL","This cross-sectional study aims to ascertain the mechanical properties of human carotid\u002Ffemoral atherosclerotic plaque and abdominal aortic aneurysm tissue and correlate tissue mechanics with novel blood-based biomarkers of cardiovascular calcification.",[67],"Vascular Diseases","2025-04-14",{"date":70,"type":71},"2025-04-17","ACTUAL",{"date":73,"type":71},"2016-01-01",{"date":75,"type":63},"2027-01-01",{"name":5,"class":6},1]