About this trial

The purpose of the CCANED-CIPHER study is to develop and validate an AI-based blood test for early cancer detection and to monitor treatment effectiveness in cancer patients. This two-phase, multi-center observational study aims to identify specific transcriptomic biomarkers in platelets and immune cells that distinguish cancer patients from healthy individuals and correlate with treatment outcomes. By analysing blood samples using artificial intelligence, the study seeks to create a safe, non-invasive method to enhance cancer diagnosis and monitor treatment responses over time.

Eligibility criteria

Qualifiers

Age: Adults aged 40 years or older.

Confirmed diagnosis of one of the following common cancers: Non-Small Cell Lung Cancer (NSCLC), Glioblastoma Multiforme (GBM), Colorectal Cancer, Hepatocellular Carcinoma (HCC), Breast Cancer, Prostate Cancer, Ovarian Cancer, Pancreatic Cancer.

Disqualifiers

Currently pregnant.

Presence of any active infectious diseases.

Use of anticoagulant or antiplatelet drugs within the past 2 weeks.

Any medical or psychological conditions that may affect the participant's ability to comply with study procedures.

Trial design

Treatments tested in this trial

  • DiNanoQ: A multi-cancer early detection (MCED) blood test
  • DiNanoTrack: Therapeutic Response Monitoring Blood Test

Treatment groups

6,000 Participants
are divided into 3 treatment groups

Locations

4
Argentina
Various Cancer Centres Rosario Argentina
Nigeria
NSIA- Lagos University Teaching Hospital Cancer Centre Lagos Nigeria
United Kingdom
Babraham Research InstituteCB22 3AT, Cambridge United Kingdom
Dysplasia Diagnostics LimitedW1W 7LT, London United Kingdom

Sponsors and collaborators

Javier Toledo

Lead sponsor

Dysplasia Diagnostics Limited

Sponsor institution