[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609095":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":29,"studyPopulation":17,"armGroups":30,"interventions":54,"overallOfficials":74,"centralContacts":78,"locations":87,"responsibleParty":109,"collaborators":17,"id":112,"slug":17,"hasResults":113,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":17,"eligibilityCriteria":117,"healthyVolunteers":118,"sex":119,"minAge":120,"maxAge":17,"enrollmentInfo":121,"targetDuration":17,"studyType":124,"phases":125,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":90,"whyStopped":17,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":144},{"fullName":5,"class":6},"Anglia Ruskin University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Maximal fat oxidation (g\u002Fmin)","Assessment of total fat oxidation from stochiometrics (based on oxygen and carbon dioxide breath to breath measurements during exercise)","Pre and post main intervention (8 days)",[14],{"measure":15,"description":16,"timeFrame":12},"Expired oxygen (L\u002Fmin)","Assessment of oxygen cost based on expired air analysis during submaximal exercise",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":21,"primaryPurpose":22,"observationalModel":17,"timePerspective":17,"maskingInfo":23},"RANDOMIZED","CROSSOVER","Participants will be randomly assigned to one of the 2 main experimental groups in a double-blinded manner. Following completion of the first round of testing, those participants consuming OliPhenolia will return after a 1 week wash out period and repeat the process but taking placebo, and vice versa. Therefore all participants will have consumed either test product or placebo. For the pre-follow up test beverage, participants will be randomly assigned to either placebo or caffeine in block manner. This exploratory study will only involve a single cross over.","BASIC_SCIENCE",{"masking":24,"maskingDescription":25,"whoMasked":26},"DOUBLE","Supplements (product, placebo and product and product + caffeine) will be provided in a randomized, double-blinded manner. Both the participants and research testers will be masked from knowing the specifics of the supplement intervention.",[27,28],"PARTICIPANT","INVESTIGATOR","This exploratory study will involve initial recruitment of approximately 30-40 healthy volunteers to undertake an initial study briefing pre-screening health questionnaire, informed written consent and familiarisation to exercise equipment, before returning to the human physiology laboratory at Anglia Ruskin University on a separate occasion (Visit 1) to undertake a standard exercise test for maximal fitness capacity.\n\nFollowing this, Visit 2 will see participants undertake a standard fat oxidation exercise test (aerobic exercise on a cycle ergometer) to ascertain maximal fat oxidation (Fatmax) with increasing exercise intensity, as well as a steady state exercise bout (30mins at FATmax).\n\nAfter this participants will begin a short-term (8 days) supplementation period of either OliPhenolia or Placebo before returning for a follow up fat oxidation assessment (Visit 3) as above. Fat oxidation will be assessed by standard respiratory measures (breath to breath for oxygen and carbon dioxide). On the follow up test (Visit 3), a pre-exercise workout drink will be provided containing either caffeine flavoured water or placebo. This is to assess whether fat oxidation can be enhanced from short-term polyphenol supplementation (OliPhenolia) with or without additional caffeine prior to exercise.\n\nParticipants will therefore be randomised into 1 of 4 groups for this study (Placebo product for 8 days + placebo beverage at follow up; Oliphenolia for 8 days + placebo beverage at follow up; and OliPhenolia for 8 days plus caffeinated beverage at follow up; and placebo product for 8 days plus caffeinated beverage at follow up).",[31,38,44,49],{"label":32,"type":33,"description":34,"interventionNames":35},"OliPhenolia® plus placebo beverage","EXPERIMENTAL","OliPhenolia® is to be consumed twice daily, away from food and separated by ≥4 hours, for a period of 8 days.\n\nNote each serving of OliPhenolia® is a volume equivalent to ≤1.0mg∙kg-1 of Hydroxytyrosol.\n\nAt the follow up test participants will also be provided with a 150mL placebo (microcrystalline cellulose at a dose of 6mg\u002Fkg) beverage pre-exercise.",[36,37],"Dietary Supplement: Concentrated olive fruit water","Dietary Supplement: Placebo beverage",{"label":39,"type":40,"description":41,"interventionNames":42},"Placebo product plus placebo beverage","PLACEBO_COMPARATOR","A taste and appearance matched placebo will be used within this research, conforming to the recipe utilised in previously published OliPhenolia® research. Recipe as follows; equal ratio \\[1:1:1\\] of prune juice, diet cola, and tonic water. The placebo formula will be provided in matched 28mL sterilised jars provided order to match OliPhenolia® original packaging.\n\nAt the follow up test participants will also be provided with a 150mL placebo (microcrystalline cellulose at a dose of 6mg\u002Fkg) beverage pre-exercise.",[43,37],"Dietary Supplement: Placebo",{"label":45,"type":33,"description":46,"interventionNames":47},"OliPhenolia® +Caffeine (pre workout)","OliPhenolia® is to be consumed twice daily, away from food and separated by ≥4 hours, for a period of 8 days.\n\nNote each serving of OliPhenolia® is a volume equivalent to ≤1.0mg∙kg-1 of Hydroxytyrosol.\n\nFor the pre workout beverage this will be a single serve drink (150mL) containing flavoured water with 6mg\u002Fkg anhydrous caffeine based on previous research. The product will only be used pre-exercise as a single bolus.",[36,48],"Dietary Supplement: Anhydrous caffeine",{"label":50,"type":51,"description":52,"interventionNames":53},"Placebo +Caffeine (pre workout)","ACTIVE_COMPARATOR","A taste and appearance matched placebo will be used within this research, conforming to the recipe utilised in previously published OliPhenolia® research. Recipe as follows; equal ratio \\[1:1:1\\] of prune juice, diet cola, and tonic water. The placebo formula will be provided in matched 28mL sterilised jars provided order to match OliPhenolia® original packaging.\n\nFor the pre workout beverage this will be a single serve drink (150mL) containing flavoured water with 6mg\u002Fkg anhydrous caffeine based on previous research. The product will only be used pre-exercise as a single bolus.",[43,48],[55,62,66,70],{"type":56,"name":57,"description":58,"armGroupLabels":59,"otherNames":60},"DIETARY_SUPPLEMENT","Concentrated olive fruit water","Supplementation of OliPhenolia twice daily for eight days. Dose equivalent to ≤1.0mg∙kg-1 of hydroxytyrosol.",[45,32],[61],"OliPhenolia",{"type":56,"name":63,"description":64,"armGroupLabels":65,"otherNames":17},"Placebo","Placebo matched for taste and appearance consumed twice daily for eight days in the equivalent volume to the experimental product.",[50,39],{"type":56,"name":67,"description":68,"armGroupLabels":69,"otherNames":17},"Anhydrous caffeine","A single bolus of flavoured water (150mL) containing 6mg\u002Fkg anhydrous caffeine taken as a pre-exercise beverage",[45,50],{"type":56,"name":71,"description":72,"armGroupLabels":73,"otherNames":17},"Placebo beverage","A single bolus of flavoured water (150mL) containing 6mg\u002Fkg microcrystalline cellulose",[32,39],[75],{"name":76,"affiliation":5,"role":77},"Justin D Roberts, Professor","PRINCIPAL_INVESTIGATOR",[79,83],{"name":76,"role":80,"phone":81,"phoneExt":17,"email":82},"CONTACT","07794122020","justin.roberts@aru.ac.uk",{"name":84,"role":80,"phone":85,"phoneExt":17,"email":86},"Joseph B Lillis","07713870153","JBL115@pgr.aru.ac.uk",[88],{"facility":89,"status":90,"city":91,"state":17,"zip":92,"country":93,"countryCode":94,"cosmosGeoPoint":95,"geoPoint":100,"contacts":101},"Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University,","RECRUITING","Cambridge","CB1 1PT","United Kingdom","UK",{"type":96,"coordinates":97},"Point",[98,99],0.11667,52.2,{"lat":99,"lon":98},[102,104,106,108],{"name":103,"role":80,"phone":81,"phoneExt":17,"email":82},"Justin D Roberts, PhD",{"name":105,"role":80,"phone":85,"phoneExt":17,"email":86},"Joseph B Lillis, MSc",{"name":105,"role":107,"phone":17,"phoneExt":17,"email":17},"SUB_INVESTIGATOR",{"name":103,"role":77,"phone":17,"phoneExt":17,"email":17},{"type":77,"investigatorFullName":110,"investigatorTitle":111,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Justin Roberts","Professor","100609095",false,"NCT07210099","The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation","The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation in Recreationally Active Volunteers","Inclusion Criteria:\n\n* Men and women, UK based, above 21 years of age with a body mass index (BMI) \\>18 and \\\u003C30 kg·m2 determined during baseline testing\n\n  * Considered to be recreationally active i.e. approximately 150mins of general physical activity\u002F exercise per week (meeting the WHO physical activity guidelines); and a VO2peak (fitness) score \\>20 and \\\u003C50 mL·kg-1·min-1 determined during baseline testing.\n  * No known history (including family history) of heart abnormalities, hypertension, coronary heart disease or diabetes (determined from pre-study health screen questionnaire).\n  * Not currently suffering from any musculoskeletal injury, or any other reason that may prevent participation in cardiovascular exercise.\n  * Have not suffered from recent viral infections ie: influenza (defined within the prior 2 months).\n  * Not taking any prescribed or over-the-counter medication which may influence exercise training (with the exception of inhalers for exercise induced asthma or contraceptive pill).\n  * Not consuming or prepared to refrain from consumption, any commercial supplementation which conflicts with the study parameters ie: antioxidants.\n  * No known allergy or intolerance to olives or prune\u002Fgrape juice, or any known side effects from caffeine ingestion.\n\nExclusion Criteria:\n\n* If any of the above criteria is not met.",true,"ALL","21 Years",{"count":122,"type":123},40,"ESTIMATED","INTERVENTIONAL",[126],"NA","There is current research interest in the use of fruit and plant-based food products containing high levels of natural antioxidants and their impact on exercise, which may be particularly beneficial for recreationally or low-active populations. One such product is an olive extract drink (called OliPhenolia®) produced by Fattoria La Vialla (an organic farm based in Northern Italy) and commercially available for the general public. Whilst previous research from the investigators (at Anglia Ruskin University) using this product has demonstrated potential antioxidant benefits and reduced oxygen cost during aerobic exercise, there are to date no studies investigating whether the short-term consumption of OliPhenolia® can benefit fat oxidation during exercise or whether such effects can be further enhanced employing a pre workout caffeinated beverage.\n\nTherefore the aim of this study is two-fold:\n\ni) to assess the impact of short-term supplementation (8 days) of OliPhenolia® relative to body mass on fat oxidation during aerobic cycling exercise in comparison to placebo in healthy recreationally active volunteers; and ii) whether potential benefits of OliPhenolia® on fat oxidation are enhanced with a pre-workout caffeinated beverage in comparison to placebo in healthy recreationally active volunteers.",[129],"Healthy",[131,132,133,134],"FatMax","Fat Oxidation","Polyphenols","Caffeine","2026-03-26",{"date":137,"type":138},"2026-03-31","ACTUAL",{"date":140,"type":138},"2025-05-30",{"date":142,"type":123},"2026-09-30",{"name":5,"class":6},1]