[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615621":3},{"organization":4,"outcomesModule":7,"designInfo":34,"detailedDescription":33,"studyPopulation":37,"armGroups":38,"interventions":44,"overallOfficials":33,"centralContacts":50,"locations":56,"responsibleParty":71,"collaborators":33,"id":73,"slug":33,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":33,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":85,"studyType":86,"phases":33,"briefSummary":87,"conditions":88,"keywords":33,"overallStatus":58,"whyStopped":33,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Peking University Shenzhen Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":33},[9],{"measure":10,"description":11,"timeFrame":12},"The effect-site concentration of cipofol, when MOAAS reaches 2","The effect-site concentration of cipofol corresponding to MOAA\u002FS score (Modified Observer's Assessment of Alertness\u002FSedation) of 2.\n\n(Modified Observer's Assessment of Alertness\u002FSedation: 5--Responds readily to name spoken in normal tone ； 4--Lethargic response to name spoken in normal tone ； 3--Responds only after name is called loudly and\u002For repeatedly ； 2--Responds only after mild prodding or shaking ；\n\n1--Responds only after painful trapezius squeeze ； 0--No response after painful trapezius squeeze；)","From the beginning of anesthesia induction until 1 minute after intubation, the MOAA\u002FS score was assessed every minute, with simultaneous recording of the effect-site concentration (Ce).",[14,17,21,25,29],{"measure":15,"description":16,"timeFrame":12},"The effect-site concentration of cipofol, when MOAA\u002FS reaches 0.","The effect-site concentration of cipofol corresponding to MOAA\u002FS score (Modified Observer's Assessment of Alertness\u002FSedation) of 0.",{"measure":18,"description":19,"timeFrame":20},"Bispectral index","Bispectral Index (BIS) values corresponding to different Modified Observer's Assessment of Alertness\u002FSedation (MOAA\u002FS) scores.","From the beginning of anesthesia induction until 1 minute after intubation, the MOAA\u002FS score was assessed every minute, with simultaneous recording of the BIS values.",{"measure":22,"description":23,"timeFrame":24},"The EC₅₀ and EC₉₅ of ciprofol","The EC₅₀ and EC₉₅ of ciprofol corresponding to MOAA\u002FS scores of 2 and 0","From the beginning of anesthesia induction until 1 minute after intubation , the MOAA\u002FS score was assessed every minute, with simultaneous recording of the effect-site concentration (Ce).",{"measure":26,"description":27,"timeFrame":28},"Heart rate","Heart rate(in bpm) corresponding to different Modified Observer's Assessment of Alertness\u002FSedation (MOAA\u002FS) scores.","From the beginning of anesthesia induction until 1 minute after intubation, the MOAA\u002FS score was assessed every minute, with simultaneous recording of the HR.",{"measure":30,"description":31,"timeFrame":32},"Blood pressure","The systolic blood pressure, diastolic blood pressure and mean arterial pressure corresponding to different MOAAS scores were all recorded.","From the beginning of anesthesia induction until 1 minute after intubation, the MOAA\u002FS score was assessed every minute, with simultaneous recording of the systolic blood pressure, diastolic blood pressure and mean arterial pressure.",null,{"allocation":33,"interventionModel":33,"interventionModelDescription":33,"primaryPurpose":33,"observationalModel":35,"timePerspective":36,"maskingInfo":33},"COHORT","PROSPECTIVE","Patients undergoing elective thyroidectomy at Peking University Shenzhen Hospital",[39],{"label":40,"type":33,"description":41,"interventionNames":42},"ciprofol group","Anesthesia induction was achieved through target-controlled infusion of ciprofol.",[43],"Drug: Ciprofol",[45],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":33},"DRUG","Ciprofol","Beginning with an initial target plasma concentration of ciprofol at 1.2 μg\u002FmL. Assessments of the Modified Observer's Assessment of Alertness\u002FSedation (MOAA\u002FS) scale and Bispectral Index (BIS) values are performed every minute until the patient achieves a complete anesthetic state (defined as an MOAA\u002FS score of 0).",[40],[51],{"name":52,"role":53,"phone":54,"phoneExt":33,"email":55},"Tao Luo","CONTACT","+86 135 1082 0779","496855048@qq.com",[57],{"facility":5,"status":58,"city":59,"state":60,"zip":33,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"RECRUITING","Shenzhen","Guangdong","China","CN",{"type":64,"coordinates":65},"Point",[66,67],114.0683,22.54554,{"lat":67,"lon":66},[70],{"name":52,"role":53,"phone":54,"phoneExt":33,"email":55},{"type":72,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100615621",false,"NCT07294989","The Effective Blood Concentration of Ciprofol","Median Effective Concentration of Ciprofol and Its Correlation With Bispectral Index: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* Scheduled for elective thyroidectomy\n* ASA physical status classification I-II\n* Willing to participate and providing written informed consent\n\nExclusion Criteria:\n\n* Recent use of sedatives or opioid analgesics\n* Severe hepatic or renal dysfunction defined as:Child-Pugh class C (score ≥10), Creatinine clearance \\\u003C35 mL\u002Fmin ,Requiring preoperative dialysis\n* Significant cardiovascular comorbidities\n* Body mass index ≥35 kg\u002Fm² or \\\u003C18.5 kg\u002Fm²\n* Known hypersensitivity or adverse reactions to propofol\u002Fciprofol\n* Neuropsychiatric disorders including:Alzheimer's disease,History of cerebrovascular events,Traumatic brain injury,Space-occupying brain lesions,Other significant neurological deficits","ALL","18 Years","65 Years",{"count":83,"type":84},101,"ESTIMATED","1 Day","OBSERVATIONAL","1. Eligible patients were selected and enrolled in the study.\n2. General anesthesia was induced using ciprofol in all participants, with standardized evaluation of consciousness levels during induction.\n3. The patients' pain and cognition are followed up after surgery.",[89],"Thyroid Disease","2026-01-05",{"date":92,"type":93},"2026-01-06","ACTUAL",{"date":95,"type":93},"2025-07-01",{"date":97,"type":84},"2026-06-30",{"name":5,"class":6},1]