[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623387":3},{"organization":4,"outcomesModule":7,"designInfo":48,"detailedDescription":51,"studyPopulation":51,"armGroups":58,"interventions":71,"overallOfficials":78,"centralContacts":85,"locations":92,"responsibleParty":104,"collaborators":51,"id":106,"slug":51,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":51,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":112,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":51,"studyType":118,"phases":119,"briefSummary":121,"conditions":122,"keywords":51,"overallStatus":94,"whyStopped":51,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Delta respiratory exchange ratio (from 23:00 till 04:00)","Measured with indirect calorimetry","Measured after 4 weeks of daily supplementation with a ketogenic nutritional supplement or non-ketogenic, isocaloric control",[14],{"measure":15,"description":16,"timeFrame":12},"Skeletal mitochondrial function","Measured in muscle biopsy",[18,20,23,26,29,31,33,36,39,42,45],{"measure":19,"description":16,"timeFrame":12},"Protein and gene markers of skeletal muscle metabolism",{"measure":21,"description":22,"timeFrame":12},"Metabolic blood markers","Measured in blood samples",{"measure":24,"description":25,"timeFrame":12},"Interstitial ketone levels","Measured with a continuous ketone monitor",{"measure":27,"description":28,"timeFrame":12},"Interstitial glucose levels","Measured with a continuous glucose monitor",{"measure":30,"description":11,"timeFrame":12},"Whole body substrate utilization",{"measure":32,"description":11,"timeFrame":12},"Whole body energy expenditure",{"measure":34,"description":35,"timeFrame":12},"Physical performances","Measured with 6-minute walk test, chair-stand-test, and handgrip strength test",{"measure":37,"description":38,"timeFrame":12},"Cognitive performance","Measured using Cambridge Neuropsychological Test Automated Battery (CANTAB) and cerebral perfusion measured with transcranial doppler ultrasound",{"measure":40,"description":41,"timeFrame":12},"Other perceivable benefits: microvasculature","Measured with retinal images",{"measure":43,"description":44,"timeFrame":12},"Other perceivable benefits: sleep quality","Measured with sleep quality questionnaires",{"measure":46,"description":47,"timeFrame":12},"Body composition","Measured with BodPod",{"allocation":49,"interventionModel":50,"interventionModelDescription":51,"primaryPurpose":52,"observationalModel":51,"timePerspective":51,"maskingInfo":53},"RANDOMIZED","CROSSOVER",null,"PREVENTION",{"masking":54,"maskingDescription":51,"whoMasked":55},"DOUBLE",[56,57],"INVESTIGATOR","OUTCOMES_ASSESSOR",[59,65],{"label":60,"type":61,"description":62,"interventionNames":63},"Ketogenic nutritional supplement","EXPERIMENTAL","Daily ketogenic nutritional supplement for 4 weeks",[64],"Dietary Supplement: ketogenic nutritional Supplement",{"label":66,"type":67,"description":68,"interventionNames":69},"non-ketogenic, isocaloric control","PLACEBO_COMPARATOR","Daily control for 4 weeks",[70],"Dietary Supplement: non-ketogenic, isocaloric control",[72,76],{"type":73,"name":74,"description":62,"armGroupLabels":75,"otherNames":51},"DIETARY_SUPPLEMENT","ketogenic nutritional Supplement",[60],{"type":73,"name":66,"description":68,"armGroupLabels":77,"otherNames":51},[66],[79,83],{"name":80,"affiliation":81,"role":82},"Joris Hoeks, Dr.","Maastricht University","PRINCIPAL_INVESTIGATOR",{"name":84,"affiliation":81,"role":82},"Peter Joris, Dr.",[86,91],{"name":87,"role":88,"phone":89,"phoneExt":51,"email":90},"Merel Timmermans, MSc","CONTACT","0031 88 3887793","merel.timmermans@maastrichtuniversity.nl",{"name":80,"role":88,"phone":51,"phoneExt":51,"email":51},[93],{"facility":81,"status":94,"city":95,"state":51,"zip":51,"country":96,"countryCode":97,"cosmosGeoPoint":98,"geoPoint":103,"contacts":51},"RECRUITING","Maastricht","Netherlands","NL",{"type":99,"coordinates":100},"Point",[101,102],5.68889,50.84833,{"lat":102,"lon":101},{"type":105,"investigatorFullName":51,"investigatorTitle":51,"investigatorAffiliation":51,"oldNameTitle":51,"oldOrganization":51},"SPONSOR","100623387",false,"NCT07395973","The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health","Inclusion Criteria:\n\n* Aged 60-80 years\n* Body mass index (BMI) 25-35 kg\u002Fm2\n* Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months)\n* Stable dietary habits (no weight loss or gain \\> 5 kg in the past 3 months)\n* Healthy (as determined by dependent physician based on medical questionnaire)\n* Regular sleeping habits (7-9h of daily sleep)\n\nExclusion Criteria:\n\n* Type 2 diabetes\n* Participants with active congestive heart failure and\u002For severe renal and or liver insufficiency\n* Uncontrolled hypertension\n* Alcohol consumption of \\>3 servings per day for men and \\>2 servings per day for women\n* Unstable body weight (weight gain or loss \\> 5 kg in the last 3 months) or intention to lose weight\n* Participants who are on an intermittent fasting diet\n* Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results\n* Significant food allergies\u002Fintolerance (seriously hampering study meals or study product)\n* Participants who do not want to be informed about unexpected medical findings\n* Blood donation during or within 2 months prior to the study\n* Disturbances in circadian rhythm determined with the follow criteria:\n* Extreme early bird or extreme night person (score ≤30 or ≥70 on MEQ-SA questionnaire)\n* Heavily varying sleep-wake rhythm\n* Night shift work during last 3 months\n* Travel across \\> 1 time zone in the last 3 months\n* High daily caffeine intake \\> 400mg (more than 4 cups of coffee or energy drinks)",true,"ALL","60 Years","80 Years",{"count":116,"type":117},14,"ESTIMATED","INTERVENTIONAL",[120],"NA","This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight\u002Fobese (BMI: 25-35 kg\u002Fm2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.",[123],"Overweight and Obesity","2026-02-03",{"date":126,"type":127},"2026-02-09","ACTUAL",{"date":129,"type":127},"2025-11-25",{"date":131,"type":117},"2027-10-31",{"name":5,"class":6},1]