About this trial
This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are:
1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women? 2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women? 3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?
Eligibility criteria
Qualifiers
18-30 years of age
Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (>2 days/week).
Fair cardiorespiratory fitness levels (Men: VO2>38.4 ml/kg/min; Women: VO2>32.6 ml/kg/min).
Disqualifiers
Hypertension (resting or diagnosed)
Impaired fasting blood glucose (>100mg/dL)
Diagnosed cardiovascular disease
Diagnosed diabetes
Trial design
Treatments tested in this trial
- Low Physical Activity and Added Carbohydrate Group
- Low physical Activity Control
- High Physical Activity and Added Carbohydrate Group
Treatment groups
Locations
1Sponsors and collaborators
University of New Hampshire
Lead sponsor