About this trial

This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are:

1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women? 2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women? 3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?

Eligibility criteria

Qualifiers

18-30 years of age

Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (>2 days/week).

Fair cardiorespiratory fitness levels (Men: VO2>38.4 ml/kg/min; Women: VO2>32.6 ml/kg/min).

Disqualifiers

Hypertension (resting or diagnosed)

Impaired fasting blood glucose (>100mg/dL)

Diagnosed cardiovascular disease

Diagnosed diabetes

Trial design

Treatments tested in this trial

  • Low Physical Activity and Added Carbohydrate Group
  • Low physical Activity Control
  • High Physical Activity and Added Carbohydrate Group

Treatment groups

45 Participants
are divided into 4 treatment groups

Locations

1
University of New Hampshire Cardiometabolic Research Laboratory03824, DurhamNew Hampshire, United States

Sponsors and collaborators

University of New Hampshire

Lead sponsor