[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635879":3},{"organization":4,"outcomesModule":7,"designInfo":79,"detailedDescription":88,"studyPopulation":78,"armGroups":89,"interventions":110,"overallOfficials":122,"centralContacts":127,"locations":78,"responsibleParty":133,"collaborators":78,"id":135,"slug":78,"hasResults":136,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":78,"eligibilityCriteria":139,"healthyVolunteers":136,"sex":140,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":78,"studyType":146,"phases":147,"briefSummary":149,"conditions":150,"keywords":78,"overallStatus":153,"whyStopped":78,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":78},{"fullName":5,"class":6},"Weifang Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":52,"otherOutcomes":78},[9,13,16,19,22,25,28,31,34,37,40,43,46,49],{"measure":10,"description":11,"timeFrame":12},"Flow-mediated dilation (FMD, relative percentage)","Flow-mediated dilation expressed as a percentage of the baseline brachial artery diameter.Unit of Measure: %","Measured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).",{"measure":14,"description":15,"timeFrame":12},"Body fat mass","Body fat mass measured by bioelectrical impedance analysis (InBody device). Unit of Measure: kg",{"measure":17,"description":18,"timeFrame":12},"Time to peak dilation","Time required to reach maximal dilation after cuff deflation.Unit of Measure: seconds",{"measure":20,"description":21,"timeFrame":12},"Basal brachial artery diameter","Baseline diameter of the brachial artery before cuff inflation.Unit of Measure: mm",{"measure":23,"description":24,"timeFrame":12},"Peak brachial artery diameter","Maximal diameter of the brachial artery after reactive hyperemia.Unit of Measure: mm",{"measure":26,"description":27,"timeFrame":12},"Absolute flow-mediated dilation (FMDabs)","Absolute change in diameter, calculated as peak diameter minus basal diameter.Unit of Measure: mm",{"measure":29,"description":30,"timeFrame":12},"Standardized FMD","Flow-mediated dilation adjusted for relevant covariates (e.g., shear stress, baseline diameter) according to standard protocols.Unit of Measure: %",{"measure":32,"description":33,"timeFrame":12},"Body weight","Body weight measured by bioelectrical impedance analysis (InBody device).Unit of Measure: kg",{"measure":35,"description":36,"timeFrame":12},"Body fat percentage","Body fat percentage measured by bioelectrical impedance analysis (InBody device).Unit of Measure: %",{"measure":38,"description":39,"timeFrame":12},"Body mass index (BMI)","Body mass index calculated from weight and height measured by bioelectrical impedance analysis (InBody device).Unit of Measure: kg\u002Fm²",{"measure":41,"description":42,"timeFrame":12},"Basal metabolic rate (BMR)","Basal metabolic rate estimated by bioelectrical impedance analysis (InBody device).Unit of Measure: kcal",{"measure":44,"description":45,"timeFrame":12},"Waist circumference","Waist circumference measured by bioelectrical impedance analysis (InBody device).Unit of Measure: cm",{"measure":47,"description":48,"timeFrame":12},"Visceral fat area","Visceral fat area measured by bioelectrical impedance analysis (InBody device). Unit of Measure: cm²",{"measure":50,"description":51,"timeFrame":12},"Skeletal muscle mass","Skeletal muscle mass measured by bioelectrical impedance analysis (InBody device).Unit of Measure: kg",[53,56,60,63,66,69,72,75],{"measure":54,"description":55,"timeFrame":12},"Systolic blood pressure (SBP)","Systolic blood pressure measured using an electronic sphygmomanometer.Unit of Measure: mmHg",{"measure":57,"description":58,"timeFrame":59},"Serum high-density lipoprotein (HDL) cholesterol concentration","Fasting serum HDL cholesterol concentration measured from blood samples. Unit of Measure: mmol\u002FL","Measured at baseline and post-intervention (after 6-8 weeks).",{"measure":61,"description":62,"timeFrame":12},"Diastolic blood pressure (DBP)","Diastolic blood pressure measured using an electronic sphygmomanometer. Unit of Measure: mmHg",{"measure":64,"description":65,"timeFrame":12},"Heart rate","Heart rate measured using an electronic sphygmomanometer.Unit of Measure: bpm (beats per minute)",{"measure":67,"description":68,"timeFrame":59},"Serum low-density lipoprotein (LDL) cholesterol concentration","Fasting serum LDL cholesterol concentration measured from blood samples. Unit of Measure: mmol\u002FL",{"measure":70,"description":71,"timeFrame":59},"Serum total cholesterol concentration","Fasting serum total cholesterol concentration measured from blood samples. Unit of Measure: mmol\u002FL",{"measure":73,"description":74,"timeFrame":59},"HDL\u002FLDL cholesterol ratio","Ratio of serum HDL cholesterol to LDL cholesterol calculated from fasting blood samples.Unit of Measure: ratio (dimensionless)",{"measure":76,"description":77,"timeFrame":59},"Serum triglyceride concentration","Fasting serum triglyceride concentration measured from blood samples.Unit of Measure: mmol\u002FL",null,{"allocation":80,"interventionModel":81,"interventionModelDescription":78,"primaryPurpose":82,"observationalModel":78,"timePerspective":78,"maskingInfo":83},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":84,"maskingDescription":85,"whoMasked":86},"SINGLE","Due to the particularity of the exercise intervention, it is not possible to blind the participants and the exercise instructors. However, it is feasible to blind the outcome assessors.",[87],"OUTCOMES_ASSESSOR","This is a parallel group randomized controlled trial, with the study subjects being overweight or obese adults (with a body mass index of ≥ 24 kg\u002Fm²). Participants will be recruited from universities and randomly assigned to one of the following four groups:\n\nShort-term stair climbing exercise group Participants climbed the stairs 4 to 5 times a day, each time ascending 5 floors (approximately 1 minute each time). There was at least a 1-hour interval between each exercise session, and the exercises were carried out during daily activities. They exercised 3 to 5 times a week for 6 to 8 weeks.\n\nLong-term stair climbing nutrition supplementation group The participants also conducted 4 to 5 stair climbing training sessions every day. Each training session consisted of 3 sets of climbing 5 floors (the total climbing height for each training session was 15 floors), with a rest period of no more than 1 minute between each set. The interval between two training sessions was no less than 1 hour. They exercised 3 to 5 times a week for 6 to 8 weeks.\n\nModerate-intensity continuous training group (MICT) Participants engaged in 30-minute moderate-intensity running (including warm-up and cool-down activities) each time, 3 to 5 times a week, for 6 to 8 weeks.\n\nControl group Participants maintained their daily activities and did not receive any exercise intervention measures.\n\nResult measurement indicators:\n\nVascular health: Assessing endothelial function through ultrasound measurement of flow-mediated vascular dilation (FMD).\n\nBody composition: Measured using the InBody body bioelectrical impedance analyzer (including muscle mass, fat mass and body fat percentage).\n\nBlood lipid test: Collect fasting blood samples and measure low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), and total cholesterol (TC).\n\nMeasurement time points: Measurements were conducted at the baseline (at the beginning of the study), 3-4 weeks (during the intervention period), and 8 weeks (after the intervention ended).\n\nThis research protocol has been approved by the Institutional Review Board of Shandong Second Medical University. All participants are required to sign a written informed consent form.",[90,96,101,106],{"label":91,"type":92,"description":93,"interventionNames":94},"Short-term stair climbing exercise snack group","EXPERIMENTAL","Participants perform short climbs of the stairs 4 to 5 times a day. Each climb involves going up 5 floors (approximately 1 minute), and there is a minimum interval of at least 1 hour between each climb.",[95],"Behavioral: Short-term stair climbing exercise snack group",{"label":97,"type":92,"description":98,"interventionNames":99},"Long-duration stair climbing exercise snack group","Participants climbed the ladder 4 to 5 times a day. Each climb consisted of 2 to 3 sets (each set involved climbing 5 floors, with a rest period of no more than 1 minute between sets), and the total number of floors climbed in a single session was 10 or 15.",[100],"Behavioral: Long-duration stair climbing exercise snack group",{"label":102,"type":92,"description":103,"interventionNames":104},"Moderate-intensity continuous exercise","The participants engaged in moderate-intensity running training for 3 to 5 days per week, with each session lasting for 30 minutes.",[105],"Behavioral: Moderate-intensity continuous exercise（MICT）",{"label":107,"type":108,"description":109,"interventionNames":78},"control group","NO_INTERVENTION","The participants did not undergo any form of exercise intervention and maintained their usual activity patterns.",[111,115,118],{"type":112,"name":91,"description":113,"armGroupLabels":114,"otherNames":78},"BEHAVIORAL","Adopt a fragmented approach, climbing stairs 4-5 times a day, each time climbing 5 floors (approximately 1 minute per session), with at least 1 hour of interval between each session, and spread throughout the daily activity periods. Exercise 3-5 days per week for a total of 6-8 weeks.",[91],{"type":112,"name":97,"description":116,"armGroupLabels":117,"otherNames":78},"On the basis of climbing stairs 4 to 5 times a day, increase the single exercise volume: complete 2 or 3 sets of climbing 5 floors of stairs each time (that is, the total number of floors climbed each time is 10 or 15), with no more than 1 minute of rest between sets. The intervals between each exercise should be at least 1 hour. Exercise 3 to 5 days a week, for a total of 6 to 8 weeks of intervention.",[97],{"type":112,"name":119,"description":120,"armGroupLabels":121,"otherNames":78},"Moderate-intensity continuous exercise（MICT）","Exercise 3 to 5 days per week for a total of 6 to 8 weeks. Perform 30 minutes of moderate-intensity running training every day.",[102],[123],{"name":124,"affiliation":125,"role":126},"YANXIA WANG, PhD","Weifang Medical University(Renamed Shandong Second Medical University)","PRINCIPAL_INVESTIGATOR",[128],{"name":129,"role":130,"phone":131,"phoneExt":78,"email":132},"XINCHEN ZHANG","CONTACT","+8615094866869","zhangxinchen2001@126.com",{"type":134,"investigatorFullName":78,"investigatorTitle":78,"investigatorAffiliation":78,"oldNameTitle":78,"oldOrganization":78},"SPONSOR","100635879",false,"NCT07558421","The Effects of Exercise Snacks on Endothelial Function and Body Composition in Overweight Individuals","Inclusion Criteria:\n\n1. Age: 18-35 years old (male, female);\n2. Clear consciousness, stable vital signs;\n3. Able to understand and follow simple instructions;\n4. No regular exercise for at least 3 months;\n5. BMI ≥ 24 kg\u002Fm2.\n\nExclusion Criteria:\n\n1. There are other serious diseases, such as tumors;\n2. There are other neurological diseases;\n3. There are serious diseases that simultaneously affect the heart, liver, kidneys, endocrine system or hematopoietic system;\n4. There is a history of alcohol or drug abuse;\n5. Participated in other clinical trials that might affect the results of this study;\n6. There are other neurological or musculoskeletal diseases, with pain worsening with exercise;\n7. It is forbidden to engage in physical training.\n8. Within the past 3 months, there have been acute cardiovascular events such as acute myocardial infarction,unstable angina pectoris, severe arrhythmia, acute heart failure, etc.；\n9. Uncontrolled hypertension；\n10. Severe pulmonary diseases, such as uncontrolled asthma, acute exacerbation of chronic obstructive pulmonary disease, interstitial lung disease with significant exercise limitation；\n11. Severe joint and bone diseases, acute soft tissue injuries, fractures that have not healed, etc., making it impossible to complete the prescribed exercise load；\n12. Presence of bleeding tendencies, coagulation dysfunction, or within the past 1 month, there has been major bleeding or a history of surgery；\n13. The investigator judges that there are any other situations that may affect the safety of the subjects or the results of the trial.","ALL","18 Years","35 Years",{"count":144,"type":145},60,"ESTIMATED","INTERVENTIONAL",[148],"NA","This randomized controlled trial investigates the effects of two types of stair-climbing exercise snacks versus moderate-intensity continuous training on vascular health, body composition, and blood lipids in overweight or obese adults. Participants will be assigned to one of four groups for 6-8 weeks. The control group receives no exercise intervention. Primary outcomes include endothelial function (ultrasound), body composition (InBody), and lipid profile (blood test).",[151,152],"Overweight","Obesity","NOT_YET_RECRUITING","2026-04-22",{"date":156,"type":157},"2026-04-30","ACTUAL",{"date":159,"type":145},"2026-04-16",{"date":161,"type":145},"2026-07-20",{"name":5,"class":6}]