[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638418":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":23,"centralContacts":23,"locations":26,"responsibleParty":43,"collaborators":23,"id":47,"slug":23,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":23,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":23,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":23,"overallStatus":65,"whyStopped":23,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"non-PRP group (control group)","SHAM_COMPARATOR","non-PRP group (control group): non-PRP in the conventional IUI",[13],"Other: non-PRP group (control group)",{"label":15,"type":16,"description":17,"interventionNames":18},"PRP group (intervention group)","EXPERIMENTAL","PRP group (intervention group): female PRP co-incubation with husband's sperm in the IUI",[19],"Other: PRP group (intervention group)",[21,24],{"type":6,"name":9,"description":11,"armGroupLabels":22,"otherNames":23},[9],null,{"type":6,"name":15,"description":17,"armGroupLabels":25,"otherNames":23},[15],[27],{"facility":28,"status":23,"city":29,"state":23,"zip":23,"country":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"The Chinese University of Hong Kong","Hong Kong","China",{"type":32,"coordinates":33},"Point",[34,35],114.17469,22.27832,{"lat":35,"lon":34},[38],{"name":39,"role":40,"phone":41,"phoneExt":23,"email":42},"Chung PW Jacqueline","CONTACT","35051537","jacquelinechung@cuhk.edu.hk",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Chung Pui Wah Jacqueline","Associate Professor","100638418",false,"NCT07615634","The Efficacy and Safety of Female PRP Co-incubation With Sperm During (IUI) Cycles","The Efficacy and Safety of Female Autologous Platelet-Rich Plasma (PRP) Co-incubation With Sperm During the Intrauterine Insemination (IUI) Cycles: A Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who were eligible for IUI cycles in Assissted Reproduction Technolog unit, Prince of Wales Hospital\n* Female patients aged \\>18 years old and \\\u003C 42 years old\n* BMI \\\u003C 30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Concurrent administration of other agents such as prednisolone, intravenous immunoglobulin, or G-CSF\n* Administration of anticoagulants or NSAIDs at least 7 days before PRP infuse\n* Drug addiction\n* Untreated urinary tract infection\n* Underlying uncontrolled diabetes or hypertension, chromosomal or uterine abnormalities, genetic, hematologic, immunological, or endocrine disorders\n* Chronic disease, systemic disease or cancers\n* Blood diseases (sepsis, thrombocytopenia)\n* Poor sperm samples (raw sample TMS \\\u003C5 x 106)\n* Smoking and drinking alcoholic beverages on the day of IUI\n* Fever on the day of IUI\n* Redduse or incomplete in obtaining informed consent","ALL","18 Years","42 Years",{"count":57,"type":58},288,"ESTIMATED","INTERVENTIONAL",[61],"NA","The investigators hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate.\n\nPrimary outcome:\n\nTo compare the incidence of clinical pregnancy outcome in those infertility patients undergoing IUI with female PRP co-incubation with husband's sperm group and non-PRP group.\n\nSecondary outcomes:\n\n* To evaluate the post-culture sperm parameters between the intervention group and control group\n* To evaluate the IUI parameter between the intervention group and control group\n* To evaluate the safeness between the female PRP co-incubation with husband's sperm in the IUI group and non-PRP group, including potential infection rate or other pregnancy outcomes such as miscarriage, multiple pregnancy, ectopic pregnancy and molar pregnancy",[64],"Reproductive Issues","NOT_YET_RECRUITING","2026-05-28",{"date":68,"type":69},"2026-05-29","ACTUAL",{"date":71,"type":58},"2026-05-21",{"date":73,"type":58},"2028-05-20",{"name":5,"class":6},1]