[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640837":3},{"organization":4,"outcomesModule":7,"designInfo":22,"detailedDescription":21,"studyPopulation":21,"armGroups":27,"interventions":34,"overallOfficials":21,"centralContacts":40,"locations":51,"responsibleParty":81,"collaborators":21,"id":83,"slug":21,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":21,"studyType":96,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":54,"whyStopped":21,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":21},[9],{"measure":10,"description":11,"timeFrame":12},"Transition from sedentary lifestyle to regular activity and completion of a 100 km ultra-trail","Percentage of participants who (i) become sufficiently active to be ready to start the Courmayeur-Champex-Chamonix (CCC) 100 km ultra-trail of the Ultra Trail du Mont-Blanc, and (ii) complete the 100 km CCC race.","up to 18 months",[14,18],{"measure":15,"description":16,"timeFrame":17},"Safety and tolerance of progressive endurance training","Rate of injuries or adverse events reported weekly, and dropout rate over the 18-month training period.","Weekly reporting during the 18-month intervention period",{"measure":19,"description":20,"timeFrame":12},"Feasibility and adherence to the endurance training program","Proportion of scheduled training sessions completed by participants and the percentage of participants finishing the 100 km CCC ultra-trail among those who started the race.",null,{"allocation":23,"interventionModel":24,"interventionModelDescription":21,"primaryPurpose":6,"observationalModel":21,"timePerspective":21,"maskingInfo":25},"NA","SINGLE_GROUP",{"masking":26,"maskingDescription":21,"whoMasked":21},"NONE",[28],{"label":29,"type":30,"description":31,"interventionNames":32},"Endurance training","EXPERIMENTAL","From March 1, 2026 to August 2027, participants will follow individualized coaching: starting at 5-6 hours per week and progressing to 7-10 hours (rarely 15 hours) per week before mountain ultra marathon",[33],"Behavioral: Intensive training",[35],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":21},"BEHAVIORAL","Intensive training","participants will follow individualized coaching: starting at 5-6 hours per week and progressing to 7-10 hours (rarely 15 hours) per week before mountain ultra marathon",[29],[41,47],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Leonard FEASSON, MD Phd","CONTACT","(0)4 77 82 83 00","+33","leonard.feasson@chu-st-etienne.fr",{"name":48,"role":43,"phone":49,"phoneExt":45,"email":50},"Céline LECLERCQ-TRAUTVETTER, CDP","04 77 82 94 27","Celine.LECLERCQ-TRAUTVETTER@chu-st-etienne.fr",[52],{"facility":53,"status":54,"city":55,"state":21,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"CHU de Saint-Etienne","RECRUITING","Saint-Etienne","42055","France","FR",{"type":60,"coordinates":61},"Point",[62,63],4.39,45.43389,{"lat":63,"lon":62},[66,68,71,73,75,77,79],{"name":67,"role":43,"phone":44,"phoneExt":45,"email":46},"Léonard FEASSON, MD Phd",{"name":69,"role":70,"phone":21,"phoneExt":21,"email":21},"David HUPIN, MD","SUB_INVESTIGATOR",{"name":72,"role":70,"phone":21,"phoneExt":21,"email":21},"Clément FOSCHIA, MD",{"name":74,"role":70,"phone":21,"phoneExt":21,"email":21},"Philippe BOIRON, MD",{"name":76,"role":70,"phone":21,"phoneExt":21,"email":21},"Renan PLANCHER, MD",{"name":78,"role":70,"phone":21,"phoneExt":21,"email":21},"Rémi VASSEUR, MD",{"name":80,"role":70,"phone":21,"phoneExt":21,"email":21},"Laurent GERGELE, MD",{"type":82,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100640837",false,"NCT07626593","The Extraordinary Endurance of the Human Species","0 TO 100","Inclusion Criteria:\n\n* Affiliation to social security.\n* Informed consent signed.\n* Male or female, aged 25-50.\n* Sedentary (\\>6h\u002Fday sitting) and inactive (no regular training), assessed by GPAQ questionnaire.\n\nExclusion Criteria:\n\n* Chronic joint or cardiac diseases.\n* Neurological disorders.\n* Legal protection status.\n* Moderate to severe depression (BDI-13 \\> 7) or use of antidepressants\u002Fanxiolytics.\n* Use of banned substances.\n* Excessive alcohol or caffeine consumption.\n* Pregnancy.\n* Inability to understand or consent.",true,"ALL","25 Years","50 Years",{"count":94,"type":95},40,"ESTIMATED","INTERVENTIONAL",[23],"We hypothesize, based on field and scientific data, that setting a very ambitious goal such as completing a mountain ultra-marathon could motivate sedentary and inactive individuals not only to begin training but also to follow a progressive yet extremely ambitious program that has not yet been studied comprehensively. Indeed, the effects of intense and prolonged endurance training (18 months) on the health and performance of completely sedentary individuals have never been investigated exhaustively.",[100],"Healthy Volunteers",[102,103,104],"Ultra-endurance","Sedentary","Healthy volunteers","2026-06-02",{"date":107,"type":108},"2026-06-04","ACTUAL",{"date":110,"type":108},"2026-02-03",{"date":112,"type":95},"2027-11",{"name":5,"class":6},1]