[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635301":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":31,"studyPopulation":34,"armGroups":35,"interventions":40,"overallOfficials":31,"centralContacts":31,"locations":46,"responsibleParty":66,"collaborators":31,"id":70,"slug":31,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":31,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":81,"studyType":82,"phases":31,"briefSummary":83,"conditions":84,"keywords":31,"overallStatus":48,"whyStopped":31,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Zhongshan Ophthalmic Center, Sun Yat-sen University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"Change in corneal thickness","Corneal thickness measured by corneal endothelial specular microscope","postoperative day 1, week 1, and month 1",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"Change in corneal endothelial cell density","Measured using corneal endothelial specular microscope","1 day, 1 week, and 1 month postoperatively",{"measure":19,"description":20,"timeFrame":17},"Best-corrected visual acuity","Measured using ETDRS visual acuity protocol with ETDRS visual acuity chart by a masked examiner",{"measure":22,"description":23,"timeFrame":24},"Intraoperative and postoperative complications","Monitored by cataract surgeons using intraoperative OCT and postoperative slit-lamp examination. Complications include Descemet membrane detachment, posterior capsule rupture, incision leakage, and etc.","Intraoperative, 1 day, 1 week, and 1 month postoperatively",[26],{"measure":27,"description":28,"timeFrame":29},"Position of Phacoemulsification","Swept-source intraoperative optical coherence tomography (SS-iOCT) will be used for real-time measurements throughout the surgery. The imaging depth will be set to 12 mm to ensure full visualization from the anterior corneal surface to the posterior lens surface. During phacoemulsification, a five-line scanning pattern will be applied, with the central line aligned with the phaco tip. The iris-lens diaphragm plane will be used as the reference standard on iOCT images. The phaco tip will be considered to be in the supracapsular space when positioned above this plane, at the iris-lens diaphragm plane when exactly at the plane, and in the endocapsular space when positioned below the plane. The duration of phaco tip manipulation in the supracapsular space, at the iris-lens diaphragm plane, and in the endocapsular space will be recorded throughout the phacoemulsification process.","During phacoemulsification",{"allocation":31,"interventionModel":31,"interventionModelDescription":31,"primaryPurpose":31,"observationalModel":32,"timePerspective":33,"maskingInfo":31},null,"COHORT","PROSPECTIVE","Patients who are planning to receive phacoemulsification combined with intraocular lens implantation for unilateral\u002Fbilateral age-related cataract",[36],{"label":37,"type":31,"description":31,"interventionNames":38},"Phacoemulsification",[39],"Procedure: cataract surgery",[41],{"type":42,"name":43,"description":44,"armGroupLabels":45,"otherNames":31},"PROCEDURE","cataract surgery","Cataract phacoemulsification combined with intraocular lens implantation",[37],[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Guangzhou","Guangdong","510000","China","CN",{"type":55,"coordinates":56},"Point",[57,58],113.25,23.11667,{"lat":58,"lon":57},[61],{"name":62,"role":63,"phone":64,"phoneExt":31,"email":65},"Zitian Liu, MD, PhD","CONTACT","+8618319249014","liuzt25@mail.sysu.edu.cn",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Zitian Liu","Dr.","100635301",false,"NCT07550907","The Impact of Surgical Procedures on Postoperative Outcomes in Cataract Phacoemulsification and Analysis of Related Factors","Inclusion Criteria:\n\n* Age ≥ 50 years and ≤ 90 years\n* Diagnosis of unilateral\u002Fbilateral age-related cataract\n* Nuclear grade ≥2 in LOCSIII classification\n* Scheduled for cataract phacoemulsification combined with intraocular lens implantation\n* Pupil size ≥6mm after dilation\n* Corneal endothelial cell count ≥1500 cells\u002Fmm²\n\nExclusion Criteria:\n\n* Diagnosis of severe systemic disease (e.g., severe hypertension or Alzheimer's disease)\n* History of ocular trauma or surgery\n* Presence of other ocular diseases (such as glaucoma, diabetic retinopathy, or high myopia)\n* Other ocular factors that may complicate the surgery (such as small pupil, shallow anterior chamber)","ALL","50 Years","90 Years",{"count":79,"type":80},300,"ESTIMATED","1 Month","OBSERVATIONAL","The goal of this observational study is to evaluate the location of phacoemulsification tip measured by intraoperative OCT during cataract surgeries and its impact on early postoperative changes of cornea and visual acuity. The main question it aims to answer is:\n\nIn patients with age-related cataracts undergoing phacoemulsification, does the location (supracapsular, iris-lens diaphragm, or endocapsular) of the phaco tip affect postoperative corneal changes and visual acuity at early postoperative stage? Eyes having phacoemulsification for cataracts will receive intraoperative OCT imaging to evaluate the location of the phaco tip during surgery, and corneal changes and visual acuity will be measured postoperatively.",[85],"Age-related Cataract","2026-06-01",{"date":88,"type":89},"2026-06-03","ACTUAL",{"date":91,"type":89},"2026-04-20",{"date":93,"type":80},"2027-06-30",{"name":5,"class":6},1]