[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100335224":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":24,"studyPopulation":13,"armGroups":25,"interventions":37,"overallOfficials":45,"centralContacts":50,"locations":59,"responsibleParty":78,"collaborators":13,"id":82,"slug":13,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":13,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":13,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":108,"whyStopped":13,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"University Hospital Hradec Kralove","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Visual injury","worsening of test for visual acuity (Rodenstock)","48 hours",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":20},"TRIPLE",[21,22,23],"PARTICIPANT","CARE_PROVIDER","OUTCOMES_ASSESSOR","Perioperative increase in intraocular pressure can be caused by prone positioning. In addition to surgical factors, patients with glaucoma, uncontrolled hypertension, arthrosclerosis, and morbid obesity are at risk for potentially damaging optic nerve and loss of optic nerve function. Some studies found that intraocular pressure values were significantly lower in patients undergoing propofol total intravenous anesthesia than in patients undergoing desflurane anesthesia during intraoperative positional changes. Pronounced vasodilatation caused by desflurane might produced hyperaemia with higher intraocular pressure. Hemodynamic response to prone position measured by near-infrared spectroscopy (NIRS) on the prefrontal cortex could determine changes caused by prone position.",[26,32],{"label":27,"type":28,"description":29,"interventionNames":30},"Desflurane Group","EXPERIMENTAL","Induction and anesthesia will be held by using desflurane",[31],"Procedure: Desflurane Group",{"label":33,"type":28,"description":34,"interventionNames":35},"Propofol Group","Induction and anesthesia will be held by using target-control anesthesia with propofol",[36],"Procedure: Propofol Group",[38,42],{"type":39,"name":27,"description":40,"armGroupLabels":41,"otherNames":13},"PROCEDURE","General anesthesia will be held using desflurane in end- tidal concentration according to target value of entropy levels (between 40 and 60).",[27],{"type":39,"name":33,"description":43,"armGroupLabels":44,"otherNames":13},"General anesthesia will be held using Schnider effect model for propofol (target control anesthesia). Titration will be done according to target value of entropy levels (between 40 and 60).",[33],[46],{"name":47,"affiliation":48,"role":49},"Pavel Dostal, MD, Ph.D.","Hradec Kralove, Czechia 50005","STUDY_DIRECTOR",[51,56],{"name":52,"role":53,"phone":54,"phoneExt":13,"email":55},"Vlasta Dostalova, MD, Ph.D.","CONTACT","+420777883571","vlasta.dostalova@fnhk.cz",{"name":47,"role":53,"phone":57,"phoneExt":13,"email":58},"+420495833218","pavel.dostal@fnhk.cz",[60],{"facility":5,"status":13,"city":61,"state":13,"zip":62,"country":63,"countryCode":13,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Hradec Králové","50005","Czechia",{"type":65,"coordinates":66},"Point",[67,68],15.83277,50.20923,{"lat":68,"lon":67},[71,75],{"name":72,"role":53,"phone":73,"phoneExt":13,"email":74},"Suchy Tomas, MD","00420495833218","suchy@fnhk.cz",{"name":76,"role":53,"phone":77,"phoneExt":13,"email":58},"Dostal Pavel, MD, PhD","00420495832828",{"type":79,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Dostalova Vlasta, MD, PhD","Principal Investigator","100335224",false,"NCT03644641","The Influence of Prone Position for Spinal Surgery on Visual Acuity","The Influence of Prone Position for Spinal Surgery on Visual Acuity, a Comparison of Volatile Anesthesia With Desflurane to Total Intravenous Anesthesia With Propofol","Inclusion Criteria:\n\n* Glasgow Coma scale 15\n* American Society of Anesthesiologists (ASA) Physical Status Classification System I-III\n* spinal surgery in duration less than 3 hours\n* sinus rhythm\n\nExclusion Criteria:\n\n* postoperative artificial ventilation\n* serious neurological disease\n* lung disease with hypercapnia\n* propofol allergy","ALL","18 Years","65 Years",{"count":92,"type":93},60,"ESTIMATED","INTERVENTIONAL",[96],"NA","This study investigated the effect of desflurane and propofol anesthesia on visual acuity in patients in prone position for spinal surgery. Many trials have investigated the effects of different anesthetic agents on intraocular pressure, propofol may reduce intraocular pressure more than other intravenous anesthetics.",[99],"Vision; Disorder, Loss",[101,102,103,104,105,106,107],"Desflurane","Near-infrared spectroscopy","Propofol","Spinal surgery","Prone position","Visual acuity","Visual loss","NOT_YET_RECRUITING","2024-05-09",{"date":111,"type":112},"2024-05-10","ACTUAL",{"date":114,"type":93},"2025-11-28",{"date":116,"type":93},"2029-12-30",{"name":5,"class":6},1]