[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640576":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":17,"overallOfficials":17,"centralContacts":30,"locations":36,"responsibleParty":197,"collaborators":199,"id":222,"slug":17,"hasResults":223,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":17,"eligibilityCriteria":227,"healthyVolunteers":223,"sex":228,"minAge":229,"maxAge":17,"enrollmentInfo":230,"targetDuration":17,"studyType":233,"phases":17,"briefSummary":234,"conditions":235,"keywords":238,"overallStatus":243,"whyStopped":17,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":253},{"fullName":5,"class":6},"Nantes University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Identification of new immune, cellular and molecular markers in patients who respond and not respond to treatment","Comparative studies of clinical, biological, genetic (HLA typing) parameters and result from omics analysis of patients groups classified according to their response to treatment and disease progression","2 years",[14],{"measure":15,"description":16,"timeFrame":12},"Understanding the molecular mechanisms of treatment efficacy and failure","Combination of immunological, histological and therapeutic analysis",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"COHORT","PROSPECTIVE","The MAI-FOIE cohort will be a prospective cohort of patients with autoimmune liver diseases followed up in 13 French centers. The multicentric nature of the cohort is a major asset, enabling the enrolment of a broad spectrum of patients, from those naïve to any immunomodulatory treatment to those refractory to therapies. The goal is to identify different treatment response profiles, markers of remission and markers of relapse risk after discontinuation of immunosuppressants in order to improve patient care.","Patients from 10 years old to patients without limit age, male or female, with Auto-Immune Hepatitis or Metabolic steatohepatitis or Drug induced Hepatitis",[24,27],{"label":25,"type":17,"description":26,"interventionNames":17},"AIH patients","Patients of both sexes, over 10 years old, with an established diagnosis of AIH (Auto Immune Hepatitis) will be eligible for inclusion during a medical care visit.",{"label":28,"type":17,"description":29,"interventionNames":17},"Control patients","Patients of both sexes, over 18 years old, with an established diagnosis of Primary Biliary Cholangitis, Metabolic Steatohepatitis or Drug-Induced Hepatitis will be eligible for inclusion during a medical care visit",[31],{"name":32,"role":33,"phone":34,"phoneExt":17,"email":35},"Jérôme GOURNAY, MD","CONTACT","+33 2.40.08.31.52","Jerome.gournay@chu-nantes.fr",[37,52,64,76,88,100,112,125,137,149,161,173,185],{"facility":38,"status":17,"city":39,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"CHU d'Angers","Angers","France","FR",{"type":43,"coordinates":44},"Point",[45,46],-0.55202,47.47156,{"lat":46,"lon":45},[49],{"name":50,"role":33,"phone":17,"phoneExt":17,"email":51},"BOURSIER Jérôme","jeboursier@chu-angers.fr",{"facility":53,"status":17,"city":54,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"CHU de Brest","Brest",{"type":43,"coordinates":56},[57,58],-4.48628,48.39029,{"lat":58,"lon":57},[61],{"name":62,"role":33,"phone":17,"phoneExt":17,"email":63},"Jean-Baptiste NOUSBAUM","jean-baptiste.nousbaum@chu-brest.fr",{"facility":65,"status":17,"city":66,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"AP-HP Beaujon","Clichy",{"type":43,"coordinates":68},[69,70],2.30952,48.90018,{"lat":70,"lon":69},[73],{"name":74,"role":33,"phone":17,"phoneExt":17,"email":75},"Audrey PAYANCE","audrey.payance@aphp.fr",{"facility":77,"status":17,"city":78,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"CHD Vendée","La Roche-sur-Yon",{"type":43,"coordinates":80},[81,82],-1.42757,46.66974,{"lat":82,"lon":81},[85],{"name":86,"role":33,"phone":17,"phoneExt":17,"email":87},"Matthieu SCHNEE","matthieu.schnee@chd-vendee.fr",{"facility":89,"status":17,"city":90,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"CHU de Lille","Lille",{"type":43,"coordinates":92},[93,94],3.05512,50.63391,{"lat":94,"lon":93},[97],{"name":98,"role":33,"phone":17,"phoneExt":17,"email":99},"Alexandre LOUVET","alexandre.louvet@chu-lille.fr",{"facility":101,"status":17,"city":102,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Hospices Civils de Lyon","Lyon",{"type":43,"coordinates":104},[105,106],4.84789,45.74906,{"lat":106,"lon":105},[109],{"name":110,"role":33,"phone":17,"phoneExt":17,"email":111},"Jérôme DUMORTIER","Jerome.dumortier@chu-lyon.fr",{"facility":113,"status":17,"city":114,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"CHU Nantes","Nantes",{"type":43,"coordinates":116},[117,118],-1.55336,47.21725,{"lat":118,"lon":117},[121,122],{"name":32,"role":33,"phone":34,"phoneExt":17,"email":35},{"name":123,"role":124,"phone":17,"phoneExt":17,"email":17},"Jérôme GOURNAY","PRINCIPAL_INVESTIGATOR",{"facility":126,"status":17,"city":127,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"AP-HP Saint-Antoine","Paris",{"type":43,"coordinates":129},[130,131],2.3488,48.85341,{"lat":131,"lon":130},[134],{"name":135,"role":33,"phone":17,"phoneExt":17,"email":136},"Sara LEMOINNE","sara.lemoinne@aphp.fr",{"facility":138,"status":17,"city":139,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"CHU Poitiers","Poitiers",{"type":43,"coordinates":141},[142,143],0.34348,46.58261,{"lat":143,"lon":142},[146],{"name":147,"role":33,"phone":17,"phoneExt":17,"email":148},"Christine SILVAIN","christine.silvain@chu-poitiers.fr",{"facility":150,"status":17,"city":151,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"CHU de Rennes","Rennes",{"type":43,"coordinates":153},[154,155],-1.67431,48.11109,{"lat":155,"lon":154},[158],{"name":159,"role":33,"phone":17,"phoneExt":17,"email":160},"Edouard BARDOU-JACQUET","edouard.bardou-jacquet@chu-rennes.fr",{"facility":162,"status":17,"city":163,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"CHU de Toulouse","Toulouse",{"type":43,"coordinates":165},[166,167],1.44367,43.60426,{"lat":167,"lon":166},[170],{"name":171,"role":33,"phone":17,"phoneExt":17,"email":172},"Christophe BUREAU","Bureau.c@chu-toulouse.fr",{"facility":174,"status":17,"city":175,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"CHU de Tours","Tours",{"type":43,"coordinates":177},[178,179],0.70398,47.39484,{"lat":179,"lon":178},[182],{"name":183,"role":33,"phone":17,"phoneExt":17,"email":184},"Laure EL KRIEF","l.elkrief@chu-tours.fr",{"facility":186,"status":17,"city":187,"state":17,"zip":17,"country":40,"countryCode":41,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"AP-HP Paul Brousse","Villejuif",{"type":43,"coordinates":189},[190,191],2.35992,48.7939,{"lat":191,"lon":190},[194],{"name":195,"role":33,"phone":17,"phoneExt":17,"email":196},"Eleonora De MARTIN","eleonora.demartin@aphp.fr",{"type":198,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[200,203,205,207,210,212,214,216,218,220],{"name":201,"class":202},"Direction Générale de l'Offre de Soins","OTHER_GOV",{"name":204,"class":202},"Institut National de la Santé Et de la Recherche Médicale, France",{"name":206,"class":202},"National Cancer Institute, France",{"name":208,"class":209},"Association Française pour l'Etude du Foie (AFEF)","UNKNOWN",{"name":211,"class":209},"ALBI",{"name":213,"class":209},"FILFOIE",{"name":215,"class":209},"GIRCIGO",{"name":217,"class":209},"CR2TI-U1064",{"name":219,"class":209},"HEPATIM-GO network",{"name":221,"class":209},"CIC IMAD","100640576",false,"NCT07594990","The MAI-FOIE Cohort","Cohorte Des Maladies Auto-Immunes du Foie","AIH (Auto-Immune Hepatitis) patients :\n\nInclusion Criteria :\n\n1. age≥10 years old\n2. weight≥25kg\n3. AIH (with or without the presence of an overlap) whose diagnosis is validated by at least 2 of the following criteria :\n\n   * ALT\\>2N or IgG\\>1.1N\n   * Presence of autoantibodies : ANA (antinuclear), ML (anti-smooth muscle), SLA (anti-soluble liver antigen), LKM1 (anti-endoplasmic reticulum), LC1 (anti-liver cytosol)\n   * Presence of interface hepatitis on biopsy\n4. signing of a written consent form for participation in the study and for the storage of biological samples research\n\nControl patients :\n\n1. age≥18 years old\n2. weight≥37kg\n3. Patient with one of the following 3 conditions :\n\n   * Primary Biliary Cholangitis\n   * Metabolic steatohepatitis\n   * Drug induced hepatitis\n\nExclusion Criteria :\n\nPositive HIV serology HBV infection Positive HCV serology and PCR Patients under guardianship or curatorship","ALL","10 Years",{"count":231,"type":232},800,"ESTIMATED","OBSERVATIONAL","The MAI-FOIE cohort will be a French multicenter cohort with the development of a biobank including patients with autoimmune, metabolic and medicated liver diseases",[236,237],"Autoimmune Liver Diseases","Immunological Mechanisms",[239,240,241,242],"Cohort","biocollection","pathophysiology","biomarkers","NOT_YET_RECRUITING","2026-06-23",{"date":246,"type":247},"2026-06-25","ACTUAL",{"date":249,"type":232},"2026-06-01",{"date":251,"type":232},"2038-05-30",{"name":5,"class":6},13]