[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634437":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":16,"studyPopulation":17,"armGroups":18,"interventions":32,"overallOfficials":36,"centralContacts":46,"locations":56,"responsibleParty":73,"collaborators":13,"id":75,"slug":13,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":13,"eligibilityCriteria":79,"healthyVolunteers":76,"sex":80,"minAge":81,"maxAge":13,"enrollmentInfo":82,"targetDuration":13,"studyType":85,"phases":13,"briefSummary":86,"conditions":87,"keywords":13,"overallStatus":59,"whyStopped":13,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Zhongnan Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Concentration of differentially expressed molecules in PACG patients with zonular laxity","Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and healthy control subjects, differentially expressed molecules will be identified and quantified by high-throughput omics sequencing and bioinformatics analysis in PACG patients with zonular laxity, and a potential mechanistic network will be constructed based on these molecular changes.","2 years",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":6,"maskingInfo":13},"CASE_CONTROL","This study investigates the pathogenesis of PACG by conducting multi-omics analyses of aqueous humor, blood and anterior lens capsule samples from PACG patients with and without concomitant zonular abnormalities, aiming to elucidate the etiology of zonular abnormalities and uncover novel mechanisms underlying their involvement in the pathogenesis of glaucoma.","PACG patients with or without zonular laxity, as well as age-related cataract patients without a history or signs of glaucoma who served as the control group.",[19,24,28],{"label":20,"type":13,"description":21,"interventionNames":22},"Case Group A","PACG patients with zonular laxity",[23],"Other: No Additional Experimental Intervention",{"label":25,"type":13,"description":26,"interventionNames":27},"Case Group B","PACG patients without zonular laxity",[23],{"label":29,"type":13,"description":30,"interventionNames":31},"Control Group","cataract patients without a history or signs of glaucoma",[23],[33],{"type":6,"name":34,"description":34,"armGroupLabels":35,"otherNames":13},"No Additional Experimental Intervention",[20,25,29],[37,40,42],{"name":38,"affiliation":5,"role":39},"Wen Zeng, doctor","STUDY_DIRECTOR",{"name":41,"affiliation":5,"role":39},"Nan Zhang, doctor",{"name":43,"affiliation":44,"role":45},"Xuetian Yu, student","The Second Clinical College of Wuhan University","PRINCIPAL_INVESTIGATOR",[47,52],{"name":48,"role":49,"phone":50,"phoneExt":13,"email":51},"Min Ke, doctor","CONTACT","18672395959","Keminyk@163.com",{"name":53,"role":49,"phone":54,"phoneExt":13,"email":55},"Xiaomin Chen, doctor","13657237773","xminchen@whu.edu.cn",[57],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Zhongnan Hospital of Wuhan University","RECRUITING","Wuhan","Hubei","430000","China","CN",{"type":66,"coordinates":67},"Point",[68,69],114.26667,30.58333,{"lat":69,"lon":68},[72],{"name":48,"role":49,"phone":50,"phoneExt":13,"email":51},{"type":74,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100634437",false,"NCT07539675","The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis","Inclusion Criteria:\n\n* Clinically diagnosed with primary angle-closure glaucoma (PACG)\n* Aged ≥ 50 years, no gender restriction\n* Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity\n* Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology\n* Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery\n\nExclusion Criteria:\n\n* Secondary glaucoma\n* History of previous intraocular surgery\n* Systemic diseases that can cause abnormal ocular zonules\n* Other severe ocular diseases\n* Long-term use of medications affecting connective tissue metabolism","ALL","50 Years",{"count":83,"type":84},150,"ESTIMATED","OBSERVATIONAL","Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.",[88],"Primary Angle-Closure Glaucoma","2026-04-13",{"date":91,"type":92},"2026-04-20","ACTUAL",{"date":94,"type":92},"2025-10-01",{"date":96,"type":84},"2027-09-30",{"name":5,"class":6},1]