[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586754":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":26,"interventions":31,"overallOfficials":20,"centralContacts":36,"locations":42,"responsibleParty":61,"collaborators":20,"id":65,"slug":20,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":20,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":20,"enrollmentInfo":73,"targetDuration":76,"studyType":77,"phases":20,"briefSummary":24,"conditions":78,"keywords":20,"overallStatus":45,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Southeast University, China","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Difference in ventilation\u002Fperfusion mismatch","ventilation\u002Fperfusion mismatch is measured by EIT","4 hours",[14,17],{"measure":15,"description":16,"timeFrame":12},"Difference in dead space","dead space is measured by EIT",{"measure":18,"description":19,"timeFrame":12},"Difference in shunt","shunt is measured by EIT",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"CASE_CROSSOVER","PROSPECTIVE","With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.","1. Intubated patients with moderate and severe ARDS (Berlin definition, PaO2\u002FFiO2 ≤200 mmHg at PEEP 5 cmH2O)\n2. undergoing deep sedation on controlled mechanical ventilation within72 hours after ARDS onset",[27],{"label":28,"type":20,"description":20,"interventionNames":29},"mechanically ventilated patients with ARDS",[30],"Other: RCexp",[32],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":20},"RCexp","patients received different RCexp",[28],[37],{"name":38,"role":39,"phone":40,"phoneExt":20,"email":41},"yuan xue yan, MD","CONTACT","+86-15901599659","18826401594@163.com",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Zhongda Hospital, School of Medicine, Southeast University","RECRUITING","Nanjing","Jiangsu","210009","China","CN",{"type":52,"coordinates":53},"Point",[54,55],118.77778,32.06167,{"lat":55,"lon":54},[58],{"name":59,"role":39,"phone":60,"phoneExt":20,"email":41},"yan xue yuan","032-83262550",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Ling Liu","PhD","100586754",false,"NCT06919484","The Physiological Effect of RCexp on Ventilation\u002FPerfusion Distribution","The Physiological Effect of RCexp on Ventilation\u002FPerfusion Distribution in Patients With ARDS","Inclusion Criteria:\n\nadult patients with ARDS receiving mechanical ventilation no more than 72 hours\n\nExclusion Criteria:\n\n1. age \\\u003C18 years old\n2. patient undergoing legal protection\n3. contra-indications to EIT (e. g. severe chest trauma or wounds)\n4. pneumothorax\n5. patient undergoing ECMO\n6. pregnancy","ALL","19 Years",{"count":74,"type":75},60,"ESTIMATED","28 Days","OBSERVATIONAL",[79,80],"Acute Respiratory Distress Syndrome","Mechanical Ventilation","2025-11-20",{"date":83,"type":84},"2025-11-26","ACTUAL",{"date":86,"type":75},"2025-11-30",{"date":88,"type":75},"2026-12-31",{"name":5,"class":6},1]