[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500271":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":63,"collaborators":66,"id":70,"slug":24,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":24,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":24,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":47,"whyStopped":24,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Rutgers, The State University of New Jersey","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Clean Air, Then Ozone","EXPERIMENTAL","Subjects will be exposed to clean air for 3 hours at the first exposure visit and 0.2ppm ozone for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.",[13,14],"Other: Clean Air","Other: Ozone",{"label":16,"type":10,"description":17,"interventionNames":18},"Ozone, Then Clean Air","Subjects will be exposed to 0.2 ppm ozone for 3 hours at the first exposure visit and clean air for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Clean Air","Subjects will be exposed to clean air for 3 hours.",[9,16],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Ozone","Subjects will be exposed to 0.2 ppm ozone for 3 hours.",[9,16],[30],{"name":31,"affiliation":32,"role":33},"Howard M Kipen, MD","Rutgers School of Public Health","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Kathleen Black, PhD","CONTACT","8484456049","kgblack@eohsi.rutgers.edu",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},"Adriana De Resende","848-445-0178","ad998@eohsi.rutgers.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Rutgers - EOHSI","RECRUITING","Piscataway","New Jersey","08854","United States",{"type":53,"coordinates":54},"Point",[55,56],-74.39904,40.49927,{"lat":56,"lon":55},[59,62],{"name":60,"role":37,"phone":61,"phoneExt":24,"email":39},"Kathy Black, PhD","848-445-6049",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},{"type":33,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Howard M. Kipen, MD, MPH","Professor",[67],{"name":68,"class":69},"National Institute of Environmental Health Sciences (NIEHS)","NIH","100500271",false,"NCT05794087","The Role of Macrophage Activation in Lung Injury Following Ozone Exposure","Activated Macrophages and Ozone Toxicity II","Exclusion Criteria:\n\n* Cardiovascular disease\n* Respiratory disease\n* Recent (within 4 weeks) respiratory or COVID-19 symptoms\n* Diabetes\n* Pregnancy\n* HIV Infection\n* History of smoking within the past 5 years.\n* Orthopedic or rheumatologic conditions which would interfere with cycle use\n* Inability to produce a sputum plug at screening\n* Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.",true,"ALL","18 Years","40 Years",{"count":81,"type":82},120,"ESTIMATED","INTERVENTIONAL",[85],"NA","The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.",[88],"Air Pollution",[90],"Macrophage","2025-12-12",{"date":93,"type":94},"2025-12-17","ACTUAL",{"date":96,"type":94},"2023-02-07",{"date":98,"type":82},"2027-06-01",{"name":5,"class":6},1]