[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632283":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":27,"locations":33,"responsibleParty":102,"collaborators":24,"id":106,"slug":24,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":107,"sex":113,"minAge":114,"maxAge":24,"enrollmentInfo":115,"targetDuration":24,"studyType":118,"phases":119,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":65,"whyStopped":24,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"Region Skane","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preoperative dental screening","EXPERIMENTAL","Preoperative dental examination with treatment if clinically indicated.",[13],"Other: Preoperative dental screening",{"label":15,"type":16,"description":17,"interventionNames":18},"No preoperative dental screening","ACTIVE_COMPARATOR","No routine dental screening prior to valve intervention.",[19],"Other: No preoperative dental screening",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Dental examination prior to valve intervention; treatment performed if indicated.",[9],null,{"type":6,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},"Patrik Gilje, MD-PhD","CONTACT","+46 (0)46171819","patrik.gilje@skane.se",[34,50,63,77,90],{"facility":35,"status":36,"city":37,"state":24,"zip":24,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Sahlgrenska University Hospital","NOT_YET_RECRUITING","Gothenburg","Sweden",{"type":40,"coordinates":41},"Point",[42,43],11.96679,57.70716,{"lat":43,"lon":42},[46],{"name":47,"role":30,"phone":48,"phoneExt":24,"email":49},"Anders Jeppsson, Professor","046313421000","anders.jeppsson@vgregion.se",{"facility":51,"status":36,"city":52,"state":24,"zip":24,"country":38,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Linköping University Hospital","Linköping",{"type":40,"coordinates":54},[55,56],15.62157,58.41086,{"lat":56,"lon":55},[59],{"name":60,"role":30,"phone":61,"phoneExt":24,"email":62},"Farkas Vanky, Professor","+4610-1030000","farkas.vanky@regionostergotland.se",{"facility":64,"status":65,"city":66,"state":24,"zip":24,"country":38,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Skane University Hospital","RECRUITING","Lund",{"type":40,"coordinates":68},[69,70],13.19321,55.70584,{"lat":70,"lon":69},[73],{"name":74,"role":30,"phone":75,"phoneExt":24,"email":76},"Anneli Olsson, RN-PhD","+46(0)46173723","anneli.t.olsson@skane.se",{"facility":78,"status":36,"city":79,"state":24,"zip":24,"country":38,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Örebro University Hospital","Örebro",{"type":40,"coordinates":81},[82,83],15.2066,59.27412,{"lat":83,"lon":82},[86],{"name":87,"role":30,"phone":88,"phoneExt":24,"email":89},"Örjan Friberg, Ass prof","+4619-602 10 00","orjan.friberg@regionorebrolan.se",{"facility":91,"status":36,"city":92,"state":24,"zip":24,"country":38,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"Karolinska University Hospital","Stockholm",{"type":40,"coordinates":94},[95,96],18.06871,59.32938,{"lat":96,"lon":95},[99],{"name":100,"role":30,"phone":101,"phoneExt":24,"email":24},"Ulrik Sartipy, Professor","+46812370000",{"type":103,"investigatorFullName":104,"investigatorTitle":105,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Patrik Gilje","Principal Investigator","100632283",false,"NCT07511673","The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.","SMILE: A Randomized Trial of Preoperative Dental Screening for the Prevention of Endocarditis, Reoperation or Death in Patients Undergoing Surgical or Transcatheter Cardiac Valve Intervention.","SMILE","Inclusion Criteria:\n\n* Age ≥18 years\n* Accepted for cardiac valve intervention\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Previous or ongoing infective endocarditis\n* Urgent surgery\n* Pain from loose tooth\u002Fteeth\n* Immunosuppressive therapy (excluding corticosteroids)\n* Inability to provide informed consent\n* Expected loss to follow-up","ALL","18 Years",{"count":116,"type":117},1300,"ESTIMATED","INTERVENTIONAL",[120],"NA","This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention. Participants are randomized 1:1 to preoperative dental screening or no screening. The primary outcome is time to first occurrence of all-cause death, redo-intervention of the index valve, or definite infective endocarditis within 2 years. The study uses registry-based follow-up to ensure complete outcome ascertainment.",[123,124],"Infective Endocarditis (IE)","Heart Valve Disease",[126,127,128,129,130],"Dental screening","valve intervention","endocarditis","TAVI","valve surgery","2026-05-15",{"date":133,"type":134},"2026-05-19","ACTUAL",{"date":136,"type":134},"2026-05-06",{"date":138,"type":117},"2036-12-01",{"name":5,"class":6},5]