[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515529":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":35,"centralContacts":40,"locations":50,"responsibleParty":82,"collaborators":84,"id":88,"slug":29,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":29,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":29,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":110,"overallStatus":52,"whyStopped":29,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Arkansas Children's Hospital Research Institute","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Sucrose sweetened beverage","ACTIVE_COMPARATOR","Sucrose (i.e. sugar): 31.2 g sugar (124.8 Kcal per serving). Participants will be asked to consume the study product once a day for 8 to 14 weeks if they have normal weight or excessive weight, respectively.",[13],"Other: Sucrose sweetened beverage",{"label":15,"type":16,"description":17,"interventionNames":18},"Stevia sweetened beverage","EXPERIMENTAL","The stevia-sweetened beverage contains 48.6 mg of steviol equivalents. Participants will be asked to consume the study product once a day for 8 to 14 weeks if they have normal weight or excessive weight, respectively.",[19],"Other: Stevia sweetened beverages",{"label":21,"type":10,"description":22,"interventionNames":23},"Calorie free flavored water beverage","Flavored water. Participants will be asked to consume the study product once a day for 8 to 14 weeks if they have normal weight or excessive weight, respectively.",[24],"Other: Calorie free flavored water beverage",[26,30,33],{"type":6,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"Children who habitually consume sugar (sucrose) - sweetened beverages who are randomized to this arm, will consume the study product for 8 to 14 weeks.",[9],null,{"type":6,"name":31,"description":27,"armGroupLabels":32,"otherNames":29},"Stevia sweetened beverages",[15],{"type":6,"name":21,"description":27,"armGroupLabels":34,"otherNames":29},[21],[36],{"name":37,"affiliation":38,"role":39},"Eva Diaz, M.D.","Arkansas Children's Nutrition Center","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":29,"email":45},"Eva C Diaz, M.D.","CONTACT","5013643056","ecdiazfuentes@uams.edu",{"name":47,"role":43,"phone":48,"phoneExt":29,"email":49},"Mario Ferruzzi, Ph.D.","5013642781","MFerruzzi@uams.edu",[51,71],{"facility":38,"status":52,"city":53,"state":54,"zip":55,"country":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Little Rock","Arkansas","72202","United States",{"type":58,"coordinates":59},"Point",[60,61],-92.28959,34.74648,{"lat":61,"lon":60},[64,68],{"name":65,"role":43,"phone":66,"phoneExt":29,"email":67},"Tonja Nolen","501-364-2853","NolenTC@archildrens.org",{"name":69,"role":43,"phone":70,"phoneExt":29,"email":45},"Eva Diaz, MD","501-364-3056",{"facility":38,"status":52,"city":53,"state":54,"zip":55,"country":56,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},{"type":58,"coordinates":73},[60,61],{"lat":61,"lon":60},[76,78],{"name":77,"role":43,"phone":70,"phoneExt":29,"email":45},"Eva C Diaz, MD",{"name":79,"role":43,"phone":80,"phoneExt":29,"email":81},"Mario Ferruzzi, PhD","5402314152","mferruzzi@vt.edu",{"type":83,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR",[85],{"name":86,"class":87},"Cargill","INDUSTRY","100515529",false,"NCT05992688","The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)","Inclusion Criteria\n\n* Age 8-12 years\n* Normal weight: BMI percentile ≥5th to \\\u003C85th\n* Excessive weight: BMI percentile ≥ 85th and \\\u003C140% of the 95th percentile or BMI ≥35 to \\\u003C40 kg\u002Fm2\n* Current consumption of sugar sweetened beverages (≥2 times \u002Fwk)\n* Low consumption of non-nutritive sweeteners (≤ 3 time\u002Fwk)\n* Willingness to consume experimental products Exclusion Criteria\n* Children with class 3 obesity (i.e., BMI ≥ 140% of the 95th percentile or BMI ≥ 40.0 kg\u002Fm2)\n* Dislike of experimental beverage taste (assessed at initial visit)\n* Asthma that requires daily use of inhalers to keep symptoms under control.\n* Asthma that requires use of rescue inhalers (e.g., albuterol) \\>2 days per week\n* Exercise induced asthma.\n* Autism spectrum disorder (e.g., Autistic disorder, Rett disorder, Asperger disorder, childhood disintegrative disorder, pervasive developmental disorder not otherwise specified (PDD-NOS).\n* Attention deficit hyperactivity disorder (ADHD) currently under medication.\n* Oppositional defiant disorder (ODD).\n* Epilepsy.\n* Cancer.\n* Chronic kidney disease.\n* Endocrine disorder (e.g., hypothyroidism and growth hormone deficiency).\n* Autoimmune diseases (e.g., lupus, thyroiditis, juvenile idiopathic arthritis)\n* Bleeding disorders (e.g., hemophilia)\n* Chronic infections (e.g., HIV, hepatitis B, hepatitis C).\n* Mental health disorders (e.g., depression and anxiety).\n* Type 2 and type 1 diabetes mellitus.\n* Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest.\n* If, during the screening or consent process, the parent or child expresses refusal to have blood drawn. However, participants may remain in the study if after initially agreeing to the blood draw and enrolling they change their minds and choose not to allow blood draws or if blood draws are unsuccessful.\n* Dislike of study products assessed at initial visit.\n* Fasting glucose ≥126 mg\u002Fdl at enrollment.\n* Fasting A1C ≥6.5% at enrollment\n* Less than 2 months since completion of antibiotics",true,"ALL","8 Years","12 Years",{"count":98,"type":99},150,"ESTIMATED","INTERVENTIONAL",[102],"NA","This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old.\n\nThe main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function relative to caloric sweeteners, and whether it provides benefits in this regard similar to water.",[105,106,107,108,109],"Adiposity","Insulin Sensitivity","Weight Gain","Blood Pressure","Lipoproteins",[111],"Cardiometabolic health","2025-12-16",{"date":114,"type":115},"2025-12-22","ACTUAL",{"date":117,"type":115},"2023-09-19",{"date":119,"type":99},"2026-11-30",{"name":5,"class":6},2]