The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial. An MCD test measures markers in the blood in order to screen for multiple cancers simultaneously. There is a need to understand how MCDs may work as cancer screening tools. The goal of cancer screening is to reduce the burden of cancer by identifying cancers before they show symptoms or signs, when treatment is likely to be most effective. In this study, adults aged 45-75 without cancer will be randomly assigned to one of 3 groups: 2 separate MCD test groups or a control group. These two MCD tests will not be compared to each other but will be compared to cancers detected in the control group. This study will provide early information on how well MCD tests perform as cancer screening tools. It will also help researchers understand how patients and their doctors make decisions about their care when the MCD test result comes back as normal (negative) or abnormal (positive).
Ages 45-75 years old
Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment
Agree to allow collection of information from their medical records for study-related purposes
Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic
Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years
Note: Persons with a history of in situ cancers (e.g., ductal carcinoma in situ of the breast, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ) or nonmelanoma skin cancer are eligible
Ongoing cancer diagnostic work-up
Ongoing participation in another study of an investigational cancer screening test or technology
National Cancer Institute (NCI)
Lead sponsor