The aim of this study is to investigate whether the voided urinary, perineal/preputial, and the fecal microbiota are different between children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the study aims to investigate if the microbiota is different according to the severity of DUI and if the microbiota is changed throughout treatment of DUI. A follow-up study will as well be performed on healthy children to investigate how the microbiota evolves with increasing age and pubertal stage. Children with OAB and DUI will be recruited from involved pediatric departments, and specimen in the form of urine, perineal/preputial swabs, and feces will be collected according to the protocol.
Overactive bladder as per International Children's Continence Society criteria (cases only).
At least two wet days per week (cases only).
No prior pharmacological treatment of OAB and DUI (cases only).
No lower urinary tract symptoms (healthy participants only).
No known urogenital abnormality affecting the lower urinary tract function.
No known gastrointestinal or neurological diseases.
No use of systemic drugs within five half-lives of the drug.
No use of systemic antibiotics within three months before inclusion
Aalborg University Hospital
Lead sponsor
Aarhus University Hospital
Collaborator
Regional Hospital West Jutland
Collaborator
Regionshospital Nordjylland
Collaborator