[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505122":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":33,"responsibleParty":101,"collaborators":19,"id":103,"slug":19,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":19,"enrollmentInfo":112,"targetDuration":19,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":128,"whyStopped":19,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":138},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Fasting mimicking diet (FMD)","EXPERIMENTAL","patients aged 65 and over, institutionalized in Long Term Care Units (USLD) or Establishments for the elderly (EHPAD).",[13],"Dietary Supplement: Fasting mimicking diet (FMD)",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DIETARY_SUPPLEMENT","D1 will correspond to a \"pre-fasting\" phase, with about 800 kcal of intake (approximately 40% of normal caloric intake) from a mono-nutrient diet (fruit, rice or potato according to the patient's preferences). Then D2 and D3 will correspond to the days of actual fasting, with 200-350 kcal of intake (10-18% of normal caloric intake) in the form of 100 ml of broth or vegetable juice (with a teaspoon of linseed oil) three times a day, and vaccination will take place on D4, after returning to a normal diet. 2 to 3 liter of water or unsweetened drink per day is required.Laxatives (unsweetened) will be prescribed and can be taken as during the fasting period.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Baptiste GRAMONT, MD","Baptiste.Gramont@chu-st-etienne.fr","PRINCIPAL_INVESTIGATOR",[26,30],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":23},"CONTACT","(0)0477829641","+33",{"name":31,"role":27,"phone":19,"phoneExt":19,"email":32},"Florence RANCON, CRA","florence.rancon@chu-st-etienne.fr",[34,49,63,78,88],{"facility":35,"status":19,"city":36,"state":19,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"EHPAD Claudinon","Le Chambon-Feugerolles","42500","France",{"type":40,"coordinates":41},"Point",[42,43],4.32149,45.39145,{"lat":43,"lon":42},[46,48],{"name":47,"role":27,"phone":19,"phoneExt":19,"email":19},"Romain JUGAND, MD",{"name":47,"role":24,"phone":19,"phoneExt":19,"email":19},{"facility":50,"status":19,"city":51,"state":19,"zip":52,"country":38,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"EHPAD Les Cèdres Malataverne","Malataverne","43200",{"type":40,"coordinates":54},[55,56],4.75326,44.48525,{"lat":56,"lon":55},[59,61],{"name":60,"role":27,"phone":19,"phoneExt":19,"email":19},"Aurélie BUISSON, MD",{"name":62,"role":24,"phone":19,"phoneExt":19,"email":19},"Aurélie BUISSON",{"facility":64,"status":19,"city":65,"state":19,"zip":66,"country":38,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"CHU de Saint-Etienne","Saint-Etienne","42055",{"type":40,"coordinates":68},[69,70],4.39,45.43389,{"lat":70,"lon":69},[73,74,75],{"name":22,"role":27,"phone":19,"phoneExt":19,"email":19},{"name":22,"role":24,"phone":19,"phoneExt":19,"email":19},{"name":76,"role":77,"phone":19,"phoneExt":19,"email":19},"Martin KILLIAN, MD","SUB_INVESTIGATOR",{"facility":79,"status":19,"city":65,"state":19,"zip":19,"country":38,"cosmosGeoPoint":80,"geoPoint":82,"contacts":83},"EHPAD de la Talaudière, la Rivière, la Croix de l'Horme",{"type":40,"coordinates":81},[69,70],{"lat":70,"lon":69},[84,86],{"name":85,"role":27,"phone":19,"phoneExt":19,"email":19},"Thomas CELARIER, PhD",{"name":87,"role":24,"phone":19,"phoneExt":19,"email":19},"Thomas CELARIER",{"facility":89,"status":19,"city":90,"state":19,"zip":91,"country":38,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"EHPAD La M.R.L","Saint-Just-Saint-Rambert","42170",{"type":40,"coordinates":93},[94,95],4.24141,45.49973,{"lat":95,"lon":94},[98,100],{"name":99,"role":27,"phone":19,"phoneExt":19,"email":19},"Anne PAVY, MD",{"name":99,"role":24,"phone":19,"phoneExt":19,"email":19},{"type":102,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100505122",false,"NCT05857241","Therapeutic Fasting and Immune Aging","Therapeutic Fasting and Immune Aging: A Pilot Study of Tolerance","JÛVENILE","Inclusion Criteria :\n\n* Patient affiliated or entitled to a social security scheme\n* Residing in a Long-Term Care Unit (LTCU) or a Facility for the Elderly Dependent (EHPAD)\n* A person deemed a priori, by the geriatrician member of the monitoring committee, to be capable of following the dietary recommendations required for the study.\n* A person deemed a priori, by the clinician in charge, to be able to follow the dietary recommendations required by the study.\n* Patient who has received informed information about the study and has co-signed a consent to participate in the study with the investigator.\n\nExclusion Criteria :\n\n* Inability and\u002For unwillingness to follow dietary recommendations and\u002For perform follow-up examinations required for the study\n* Iso-resource group 1 or 2 according to the AGGIR grid\n* BMI \\\u003C 18.5 kg\u002Fm2 or recent weight loss \\> 5% in 1 month or recent weight loss \\> 10% in 6 months from previous weight\n* Albuminemia \\\u003C 30g\u002Fl\n* All swallowing disorders requiring a specific diet.\n* Influenza vaccination received prior to inclusion\n* Episode of influenza or suspected influenza during the 2020-2021 season and prior to inclusion\n* Any acute medical or surgical event less than 2 weeks prior to inclusion\n* Presence of systemic inflammatory or autoimmune disease\n* Presence of an innate or acquired immune deficiency (including taking immunosuppressive treatment)\n* Presence of a chronic disease which, according to the physician, makes the follow-up of a \"fasting diet\" and\u002For the consumption of large amounts of liquids (cf. fasting diet modalities) risky (e.g. insulin-dependent or insulin-requiring diabetes, severe heart failure, severe kidney failure, active cancer, significant undernutrition...) or impossible (e.g. advanced neurodegenerative pathology).","ALL","65 Years",{"count":113,"type":114},20,"ESTIMATED","INTERVENTIONAL",[117],"NA","Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity\u002Fadaptability of the lymphocyte repertoire. The consequences of immunosenescence are multiple, including increased susceptibility to infections and poorer vaccine responses.",[120,121],"Fasting","Diet, Healthy",[123,124,125,126,127],"Fasting mimicking diet","Aged","immunology","immunosenescence","tolerance","NOT_YET_RECRUITING","2025-04-07",{"date":131,"type":132},"2025-04-08","ACTUAL",{"date":134,"type":114},"2025-04",{"date":136,"type":114},"2026-03",{"name":5,"class":6},5]