[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100313324":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":13,"centralContacts":18,"locations":25,"responsibleParty":41,"collaborators":10,"id":43,"slug":10,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"Severe eye dryness",null,{"label":12,"type":10,"description":10,"interventionNames":10},"absence of eye dryness",[14],{"name":15,"affiliation":16,"role":17},"Eric GABISON","Fondation Ophtalmologique A. de Rothschild","PRINCIPAL_INVESTIGATOR",[19],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},"Amélie YAVCHITZ","CONTACT","01.48.03.64.33","+33","ayavchitz@for.paris",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":30,"country":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Fondation Ophtalmologique A de Rothschild","RECRUITING","Paris","75019","France",{"type":33,"coordinates":34},"Point",[35,36],2.3488,48.85341,{"lat":36,"lon":35},[39],{"name":15,"role":21,"phone":10,"phoneExt":10,"email":40},"egabison@for.paris",{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100313324",false,"NCT03358979","Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)","ALTESSE","Patients:\n\nInclusion criteria\n\n* 18 years and over\n* Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes\n* Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced\n\nExclusion criteria - Known pregnancy or breastfeeding\n\nControl subjects:\n\nInclusion criteria\n\n\\- 18 years and over\n\nExclusion criteria\n\n* Wearer of contact lenses\n* Topical ocular treatment\n* Known pregnancy or breastfeeding","ALL","18 Years",{"count":52,"type":53},100,"ESTIMATED","OBSERVATIONAL","Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.",[57,58],"Conjunctival Diseases","Dry Eye Syndromes",[57,58,60,61],"Antigens","CD147","2025-12-02",{"date":64,"type":65},"2025-12-08","ACTUAL",{"date":67,"type":65},"2017-12-14",{"date":69,"type":53},"2027-03",{"name":5,"class":6},1]