[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600177":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":43,"collaborators":11,"id":45,"slug":11,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":11,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":11,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":11,"overallStatus":28,"whyStopped":11,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"The First Affiliated Hospital of Xinxiang Medical College","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Tissue-engineered cartilage to repair articular cartilage defects","EXPERIMENTAL",null,[13],"Device: Tissue engineered cartilage",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DEVICE","Tissue engineered cartilage","Cartilage constructed by autologous bone marrow mesenchymal stem cells",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Wenjie Ren","CONTACT","8613937354075","13937354075@163.com",[27],{"facility":5,"status":28,"city":29,"state":30,"zip":31,"country":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Xinxiang","Henan","453000","China",{"type":34,"coordinates":35},"Point",[36,37],113.80151,35.19033,{"lat":37,"lon":36},[40,42],{"name":22,"role":23,"phone":41,"phoneExt":11,"email":25},"13937354075",{"name":22,"role":23,"phone":11,"phoneExt":11,"email":25},{"type":44,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100600177",false,"NCT07094100","Tissue Engineered Cartilage to Repairing Articular Cartilage Defects","Clinical Study of Cartilage Constructed by Autologous Bone Marrow Mesenchymal Stem Cells in Repairing Articular Cartilage Defects","Inclusion Criteria:\n\n1. The patients' age ranges from 18 to 65 years old, and gender is not restricted;\n2. The imaging results show that the epiphyseal growth is mature;\n3. The defects or localized injuries of joint cartilage caused by trauma or other reasons;\n4. The injured area is the distal weight-bearing surface of the femoral condyle of the knee joint, with no more than 4 lesions, and there is no injury to the cruciate ligaments;\n5. The patients voluntarily sign and provide a written informed consent form and are willing to closely cooperate with the doctor's strict postoperative rehabilitation program.\n\nExclusion Criteria:\n\n1. The patient is extremely overweight, with a body mass index greater than 35;\n2. The lower limb alignment is valgus by more than 10° and varus by more than 5°;\n3. Multiple ligament injuries;\n4. There are numerous bad habits such as heavy smoking, drug abuse, and excessive alcohol consumption;\n5. Has undergone open knee joint surgery within the past six months;\n6. Has severe joint stiffness or fibrosis;\n7. Has an allergic constitution or a history of allergic reactions to collagen;\n8. Has mental abnormalities;\n9. Cannot or is unwilling to undergo rehabilitation training;\n10. Has primary cardiovascular diseases, lung diseases, endocrine and metabolic disorders, or other serious diseases that affect their daily life, such as tumors or AIDS;\n11. Pregnant or lactating women, or those planning to conceive during the trial period;\n12. Other acute or chronic diseases, for which the researchers consider surgery to be inappropriate.","ALL","18 Years","65 Years",{"count":55,"type":56},30,"ESTIMATED","INTERVENTIONAL",[59],"NA","The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.",[62,63],"Cartilage Injury","OA Knee","2026-04-28",{"date":66,"type":67},"2026-05-04","ACTUAL",{"date":69,"type":56},"2026-04-20",{"date":71,"type":56},"2028-12",{"name":5,"class":6},1]