[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611196":3},{"organization":4,"outcomesModule":7,"designInfo":31,"detailedDescription":22,"studyPopulation":22,"armGroups":37,"interventions":47,"overallOfficials":22,"centralContacts":54,"locations":60,"responsibleParty":76,"collaborators":79,"id":83,"slug":22,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":84,"sex":90,"minAge":91,"maxAge":22,"enrollmentInfo":92,"targetDuration":22,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":63,"whyStopped":22,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Grigore T. Popa University of Medicine and Pharmacy","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":27},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Ultrasonographic assessment of muscle mass","Ultrasonographic muscle assessment is standardised in the assessment of muscle according to the SARCUS (Sarcopenia through UltraSound) working group recommendations. Rectus femoris muscle will be evaluated at 50% distance between the anterior superior iliac spine and the superior pole of the patella, in a lying position with knees in 10°, for muscle thickness and muscle cross-sectional area (CSA). Three measurements will be taken for each data point, and the average value will be used for further analysis. The biceps brachii muscle will be evaluated at 50% distance acromioclavicular joint and the elbow crease, in a supine position. Muscle thickness can be easily defined as the maximal vertical distance between the superficial and deep fasciae.","From enrollment to 5 days after surgery",{"measure":14,"description":15,"timeFrame":12},"Muscle function assessment","Measuring grip strength is simple and inexpensive. Grip strength will be determined bilaterally. Each measurement will be performed three times on the left and right extremities with 20 seconds intervals between the measurements. The maximum measured value in kilograms will be used for analysis.",{"measure":17,"description":18,"timeFrame":12},"Bioimpedance assessment of lean and fat tissue mass","The bioimpedance measurements will be performed by a trained operator according to the manufacturer's recommendations. The Body Composition Monitor provides a quantitative measure of lean tissue and fat tissue mass. In contrast to earlier bioimpedance methodologies, the bioimpedance spectroscopy expresses body composition as a three-compartment model, providing overhydration, lean tissue index (LTI), and fat tissue index (FTI), whereby LTI and FTI are the respective tissue masses normalized to height squared.",[20,24],{"measure":21,"description":22,"timeFrame":23},"Hospital length of stay",null,"From enrollment to the patient discharge, up to 52 weeks",{"measure":25,"description":22,"timeFrame":26},"Mortality","28 and 90-day mortality after surgery",[28],{"measure":29,"description":30,"timeFrame":12},"Correlation","Correlation between muscle strength and muscle mass using dynamometry and echography and bioimpedance at different time points",{"allocation":32,"interventionModel":33,"interventionModelDescription":22,"primaryPurpose":34,"observationalModel":22,"timePerspective":22,"maskingInfo":35},"RANDOMIZED","PARALLEL","DIAGNOSTIC",{"masking":36,"maskingDescription":22,"whoMasked":22},"NONE",[38,43],{"label":39,"type":40,"description":22,"interventionNames":41},"total intravenous anaesthesia","ACTIVE_COMPARATOR",[42],"Procedure: total intravenous anaesthesia",{"label":44,"type":40,"description":22,"interventionNames":45},"sevoflurane anaesthesia",[46],"Procedure: sevoflurane anaesthesia",[48,52],{"type":49,"name":39,"description":50,"armGroupLabels":51,"otherNames":22},"PROCEDURE","evaluate the impact of the type of anaesthesia (total intravenous anaesthesia (TIVA)\u002Fsevoflurane anaesthesia) for colorectal surgery on the muscle function and mass",[39],{"type":49,"name":44,"description":50,"armGroupLabels":53,"otherNames":22},[44],[55],{"name":56,"role":57,"phone":58,"phoneExt":22,"email":59},"Ianis Siriopol","CONTACT","+40 746215 967","ianis.siriopol@gmail.com",[61],{"facility":62,"status":63,"city":64,"state":22,"zip":22,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Regional Institute of Oncology, Iaşi, Romania","RECRUITING","Iași","Romania","RO",{"type":68,"coordinates":69},"Point",[70,71],27.6,47.16667,{"lat":71,"lon":70},[74],{"name":56,"role":57,"phone":75,"phoneExt":22,"email":59},"+40 746 215 967",{"type":77,"investigatorFullName":56,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Lecturer",[80],{"name":81,"class":82},"Regional Institute of Oncology, Iasi, Romania","UNKNOWN","100611196",false,"NCT07237438","TIVA Versus Balanced Anesthesia on Muscle Mass in CRC Surgery","Total Intravenous Anesthesia Versus Balanced Anesthesia on Loss of Muscle Mass After Colorectal Cancer Surgery","TIVABAL-CRC","Inclusion Criteria:\n\n• adult patients diagnosed with colorectal cancer and scheduled for open colorectal surgery at the Regional Institute of Oncology, Iaşi, Romania\n\nExclusion Criteria:\n\n* lack the capacity to consent\n* extremity amputation\n* paraplegia\n* diseases affecting the muscles (such as stroke, lower-limb immobilization from a plaster, neurodegenerative diseases, peripheral neuropathy or muscle dystrophy)\n* terminal cancer","ALL","18 Years",{"count":93,"type":94},40,"ESTIMATED","INTERVENTIONAL",[97],"NA","This study is aimed at clarifying changes in body composition during the perioperative period and identifying risk factors for skeletal muscle mass loss in patients with colorectal cancer. The investigators will asess the impact of the type of anaesthesia (total intravenous anaesthesia\u002Fsevoflurane anaesthesia) for colorectal surgery on the muscle function and mass, which will be evaluated using ultrasound, dynamometry and bioimpedance.",[100,101],"Colorectal Cancer (CRC)","Sarcopenia",[103,104,105,106],"colorectal cancer","sarcopenia","ultrasound","bioimpedance","2025-11-16",{"date":109,"type":110},"2025-11-19","ACTUAL",{"date":112,"type":110},"2025-09-20",{"date":114,"type":94},"2026-06",{"name":5,"class":6},1]